Lateral transfers of large DNA fragments spread functional genes among grasses

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cg.contributor.affiliationUniversity of Sheffielden
cg.contributor.affiliationUniversity of Bernen
cg.contributor.affiliationChinese Academy of Sciencesen
cg.contributor.affiliationInternational Rice Research Instituteen
cg.contributor.affiliationUniversity of Georgiaen
cg.contributor.affiliationInstitut de Recherche pour le Développementen
cg.identifier.doihttps://doi.org/10.1073/pnas.1810031116en
cg.issn0027-8424en
cg.issue10en
cg.journalProceedings of the National Academy of Sciencesen
cg.volume116en
dc.contributor.authorDunning, Luke T.en
dc.contributor.authorOlofsson, Jill K.en
dc.contributor.authorParisod, Christianen
dc.contributor.authorChoudhury, Rimjhim Royen
dc.contributor.authorMoreno-Villena, Jose J.en
dc.contributor.authorYang, Yangen
dc.contributor.authorDionora, Jacquelineen
dc.contributor.authorQuick, W. Paulen
dc.contributor.authorPark, Minkyuen
dc.contributor.authorBennetzen, Jeffrey L.en
dc.contributor.authorBesnard, Guillaumeen
dc.contributor.authorNosil, Patriken
dc.contributor.authorOsborne, Colin P.en
dc.contributor.authorChristin, Pascal-Antoineen
dc.date.accessioned2024-12-19T12:54:14Zen
dc.date.available2024-12-19T12:54:14Zen
dc.identifier.urihttps://hdl.handle.net/10568/164729
dc.titleLateral transfers of large DNA fragments spread functional genes among grassesen
dcterms.abstractA fundamental tenet of multicellular eukaryotic evolution is that vertical inheritance is paramount, with natural selection acting on genetic variants transferred from parents to offspring. This lineal process means that an organism’s adaptive potential can be restricted by its evolutionary history, the amount of standing genetic variation, and its mutation rate. Lateral gene transfer (LGT) theoretically provides a mechanism to bypass many of these limitations, but the evolutionary importance and frequency of this process in multicellular eukaryotes, such as plants, remains debated. We address this issue by assembling a chromosome-level genome for the grass Alloteropsis semialata , a species surmised to exhibit two LGTs, and screen it for other grass-to-grass LGTs using genomic data from 146 other grass species. Through stringent phylogenomic analyses, we discovered 57 additional LGTs in the A. semialata nuclear genome, involving at least nine different donor species. The LGTs are clustered in 23 laterally acquired genomic fragments that are up to 170 kb long and have accumulated during the diversification of Alloteropsis. The majority of the 59 LGTs in A. semialata are expressed, and we show that they have added functions to the recipient genome. Functional LGTs were further detected in the genomes of five other grass species, demonstrating that this process is likely widespread in this globally important group of plants. LGT therefore appears to represent a potent evolutionary force capable of spreading functional genes among distantly related grass species.en
dcterms.accessRightsOpen Access
dcterms.available2019-02-20
dcterms.bibliographicCitationDunning, Luke T.; Olofsson, Jill K.; Parisod, Christian; Choudhury, Rimjhim Roy; Moreno-Villena, Jose J.; Yang, Yang; Dionora, Jacqueline; Quick, W. Paul; Park, Minkyu; Bennetzen, Jeffrey L.; Besnard, Guillaume; Nosil, Patrik; Osborne, Colin P. and Christin, Pascal-Antoine. 2019. Lateral transfers of large DNA fragments spread functional genes among grasses. Proc. Natl. Acad. Sci. U.S.A., Volume 116 no. 10 p. 4416-4425en
dcterms.extentpp. 4416-4425en
dcterms.issued2019-03-05
dcterms.languageen
dcterms.licenseCC-BY-NC-ND-4.0
dcterms.publisherNational Academy of Sciencesen
dcterms.typeJournal Article

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