Genome-wide scans identify known and novel regions associated with prolificacy and reproduction traits in a sub-Saharan African indigenous sheep (Ovis aries)

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cg.authorship.typesCGIAR and developing country instituteen
cg.authorship.typesCGIAR and advanced research instituteen
cg.contributor.affiliationSouthern Agricultural Research Institute, Ethiopiaen
cg.contributor.affiliationHawassa Universityen
cg.contributor.affiliationUniversity of Natural Resources and Life Sciences, Viennaen
cg.contributor.affiliationUniversity of Edinburghen
cg.contributor.affiliationInternational Center for Agricultural Research in the Dry Areasen
cg.contributor.affiliationIowa State Universityen
cg.contributor.crpLivestock
cg.coverage.regionAfrica
cg.coverage.regionSub-Saharan Africa
cg.creator.identifierAynalem: 0000-0001-5914-0487
cg.creator.identifierBarbara Rischkowsky: 0000-0002-0035-471X
cg.creator.identifierMourad Rekik: 0000-0001-7455-2017
cg.creator.identifierJoram Mwacharo: 0000-0001-6981-8140
cg.howPublishedFormally Publisheden
cg.identifier.doihttps://doi.org/10.1007/s00335-019-09820-5en
cg.isijournalISI Journalen
cg.issn1432-1777en
cg.issue11-12en
cg.journalMammalian Genomeen
cg.reviewStatusPeer Reviewen
cg.subject.ilriANIMAL BREEDINGen
cg.subject.ilriBREEDSen
cg.subject.ilriGENETICSen
cg.subject.ilriINDIGENOUS BREEDSen
cg.subject.ilriSHEEPen
cg.subject.ilriSMALL RUMINANTSen
cg.volume30en
dc.contributor.authorDolebo, Asrat T.en
dc.contributor.authorKhayatzadeh, Negaren
dc.contributor.authorMelesse, Aberraen
dc.contributor.authorWragg, Daviden
dc.contributor.authorRekik, Mouraden
dc.contributor.authorHaile, Aynalemen
dc.contributor.authorRischkowsky, Barbara A.en
dc.contributor.authorRothschild, Max F.en
dc.contributor.authorMwacharo, Joram M.en
dc.date.accessioned2020-04-14T07:41:41Zen
dc.date.available2020-04-14T07:41:41Zen
dc.identifier.urihttps://hdl.handle.net/10568/107976
dc.titleGenome-wide scans identify known and novel regions associated with prolificacy and reproduction traits in a sub-Saharan African indigenous sheep (Ovis aries)en
dcterms.abstractMaximizing the number of offspring born per female is a key functionality trait in commercial- and/or subsistence-oriented livestock enterprises. Although the number of offspring born is closely associated with female fertility and reproductive success, the genetic control of these traits remains poorly understood in sub-Saharan Africa livestock. Using selection signature analysis performed on Ovine HD BeadChip data from the prolific Bonga sheep in Ethiopia, 41 candidate regions under selection were identified. The analysis revealed one strong selection signature on a candidate region on chromosome X spanningBMP15, suggesting this to be the primary candidate prolificacy gene in the breed. The analysis also identified several candidate regions spanning genes not reported before in prolific sheep but underlying fertility and reproduction in other species. The genes associated with female reproduction traits includedSPOCK1(age at first oestrus),GPR173(mediator of ovarian cyclicity),HB-EGF(signalling early pregnancy success) andSMARCAL1andHMGN3a(regulate gene expression during embryogenesis). The genes involved in male reproduction wereFOXJ1(sperm function and successful fertilization) andNME5(spermatogenesis). We also observed genes such asPKD2L2,MAGED1andKDM3B, which have been associated with diverse fertility traits in both sexes of other species. The results confirm the complexity of the genetic mechanisms underlying reproduction while suggesting that prolificacy in the Bonga sheep, and possibly African indigenous sheep is partly under the control ofBMP15while other genes that enhance male and female fertility are essential for reproductive fitness.en
dcterms.accessRightsOpen Access
dcterms.audienceScientistsen
dcterms.available2019-11-22
dcterms.bibliographicCitationDolebo, A.T., Khayatzadeh, N., Melesse, A., Wragg, D.,· Rekik, M., Haile, A., Rischkowsky, B., Rothschild, M.F. and Mwacharo, J.M. 2019. Genome-wide scans identify known and novel regions associated with prolificacy and reproduction traits in a sub-Saharan African indigenous sheep (Ovis aries). Mammalian Genome 30:339–352.en
dcterms.extentp. 339-352en
dcterms.issued2019-12
dcterms.languageen
dcterms.licenseCC-BY-4.0
dcterms.publisherSpringeren
dcterms.subjectanimal breedingen
dcterms.subjectbreedsen
dcterms.subjectsheepen
dcterms.subjectsmall ruminantsen
dcterms.subjectgeneticsen
dcterms.subjectindigenous breedsen
dcterms.typeJournal Article

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