Genomic regions and candidate genes associated with milk production traits in Holstein and its crossbred cattle: A review

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cg.authorship.typesCGIAR and developing country instituteen
cg.contributor.affiliationHawassa Universityen
cg.contributor.affiliationDebre Berhan Universityen
cg.contributor.affiliationInternational Livestock Research Instituteen
cg.howPublishedFormally Publisheden
cg.identifier.doihttps://doi.org/10.1155/2023/8497453en
cg.isijournalISI Journalen
cg.issn2314-4378en
cg.journalInternational Journal of Genomicsen
cg.reviewStatusPeer Reviewen
cg.subject.ilriANIMAL BREEDINGen
cg.subject.ilriBREEDSen
cg.subject.ilriCATTLEen
cg.subject.ilriDAIRYINGen
cg.subject.ilriGENETICSen
cg.volume2023en
dc.contributor.authorBekele, R.en
dc.contributor.authorTaye, M.en
dc.contributor.authorAbebe, G.en
dc.contributor.authorMeseret, Selamen
dc.date.accessioned2023-08-18T12:00:44Zen
dc.date.available2023-08-18T12:00:44Zen
dc.identifier.urihttps://hdl.handle.net/10568/131587
dc.titleGenomic regions and candidate genes associated with milk production traits in Holstein and its crossbred cattle: A reviewen
dcterms.abstractGenome-wide association studies (GWAS) are a powerful tool for identifying genomic regions and causative genes associated with economically important traits in dairy cattle, particularly complex traits, such as milk production. This is possible due to advances in next-generation sequencing technology. This review summarized information on identified candidate genes and genomic regions associated with milk production traits in Holstein and its crossbreds from various regions of the world. Milk production traits are important in dairy cattle breeding programs because of their direct economic impact on the industry and their close relationship with nutritional requirements. GWAS has been used in a large number of studies to identify genomic regions and candidate genes associated with milk production traits in dairy cattle. Many genomic regions and candidate genes have already been identified in Holstein and its crossbreds. Genes and single nucleotide polymorphisms (SNPs) that significantly affect milk yield (MY) were found in all autosomal chromosomes except chromosomes 27 and 29. Half of the reported SNPs associated with fat yield and fat percentage were found on chromosome 14. However, a large number of significant SNPs for protein yield (PY) and protein percentage were found on chromosomes 1, 5, and 20. Approximately 155 SNPs with significant influence on multiple milk production traits have been identified. Several promising candidate genes, including diacylglycerol O-acyltransferase 1, plectin, Rho GTPase activating protein 39, protein phosphatase 1 regulatory subunit 16A, and sphingomyelin phosphodiesterase 5 were found to have pleiotropic effects on all five milk production traits. Thus, to improve milk production traits it is of practical relevance to focus on significant SNPs and pleiotropic genes frequently found to affect multiple milk production traits.en
dcterms.accessRightsOpen Access
dcterms.audienceScientistsen
dcterms.bibliographicCitationBekele, R., Taye, M., Abebe, G. and Meseret, S. 2023. Genomic regions and candidate genes associated with milk production traits in Holstein and its crossbred cattle: A review. International Journal of Genomics 2023:8497453.en
dcterms.extentpp. 1-18en
dcterms.issued2023-07-27
dcterms.languageen
dcterms.licenseCC-BY-4.0
dcterms.publisherHindawi Limiteden
dcterms.subjectdairy cattleen
dcterms.subjectcrossbredsen
dcterms.subjectdairyingen
dcterms.subjectcattleen
dcterms.subjectgenomicsen
dcterms.subjectgeneticsen
dcterms.subjectanimal breedingen
dcterms.subjectmolecular biologyen
dcterms.subjectbiochemistryen
dcterms.typeJournal Article

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