Whole genome detection of signature of positive selection in African cattle reveals selection for thermotolerance

cg.authorship.typesCGIAR and advanced research instituteen
cg.contributor.affiliationBahir Dar Universityen
cg.contributor.affiliationSeoul National Universityen
cg.contributor.affiliationInternational Livestock Research Instituteen
cg.contributor.affiliationNational Institute of Animal Science, Republic of Koreaen
cg.contributor.affiliationChonbuk National Universityen
cg.contributor.affiliationShinshu Universityen
cg.contributor.crpLivestock
cg.contributor.donorRural Development Administration, Republic of Koreaen
cg.coverage.regionAfrica
cg.creator.identifierTadelle Dessie: 0000-0002-1630-0417
cg.creator.identifierOlivier Hanotte: 0000-0002-2877-4767
cg.creator.identifierAlly Okeyo Mwai: 0000-0003-2379-7801
cg.creator.identifierStephen J Kemp: 0000-0003-4041-1720
cg.howPublishedFormally Publisheden
cg.identifier.doihttps://doi.org/10.1111/asj.12851en
cg.isijournalISI Journalen
cg.issn1740-0929en
cg.issue12en
cg.journalAnimal Science Journalen
cg.reviewStatusPeer Reviewen
cg.subject.ilriANIMAL BREEDINGen
cg.subject.ilriCATTLEen
cg.subject.ilriGENETICSen
cg.subject.ilriLIVESTOCKen
cg.subject.ilriRESEARCHen
cg.volume88en
dc.contributor.authorTaye, M.en
dc.contributor.authorWonseok Leeen
dc.contributor.authorCaetano-Anolles, Kelseyen
dc.contributor.authorDessie, Tadelleen
dc.contributor.authorHanotte, Olivier H.en
dc.contributor.authorOkeyo Mwai, Allyen
dc.contributor.authorKemp, Stephen J.en
dc.contributor.authorSeoae Choen
dc.contributor.authorSung Jong Ohen
dc.contributor.authorHak-Kyo Leeen
dc.contributor.authorHeebal Kimen
dc.date.accessioned2018-01-18T13:46:38Zen
dc.date.available2018-01-18T13:46:38Zen
dc.identifier.urihttps://hdl.handle.net/10568/90521
dc.titleWhole genome detection of signature of positive selection in African cattle reveals selection for thermotoleranceen
dcterms.abstractAs African indigenous cattle evolved in a hot tropical climate, they have developed an inherent thermotolerance; survival mechanisms include a light‐colored and shiny coat, increased sweating, and cellular and molecular mechanisms to cope with high environmental temperature. Here, we report the positive selection signature of genes in African cattle breeds which contribute for their heat tolerance mechanisms. We compared the genomes of five indigenous African cattle breeds with the genomes of four commercial cattle breeds using cross‐population composite likelihood ratio (XP‐CLR) and cross‐population extended haplotype homozygosity (XP‐EHH) statistical methods. We identified 296 (XP‐EHH) and 327 (XP‐CLR) positively selected genes. Gene ontology analysis resulted in 41 biological process terms and six Kyoto Encyclopedia of Genes and Genomes pathways. Several genes and pathways were found to be involved in oxidative stress response, osmotic stress response, heat shock response, hair and skin properties, sweat gland development and sweating, feed intake and metabolism, and reproduction functions. The genes and pathways identified directly or indirectly contribute to the superior heat tolerance mechanisms in African cattle populations. The result will improve our understanding of the biological mechanisms of heat tolerance in African cattle breeds and opens an avenue for further study.en
dcterms.accessRightsOpen Access
dcterms.audienceScientistsen
dcterms.available2017-07-27
dcterms.bibliographicCitationTaye, M., Wonseok Lee, Caetano-Anolles, K., Dessie, T., Hanotte, O., Ally Mwai, O., Kemp, S., Seoae Cho, Sung Jong Oh, Hak-Kyo Lee, Heebal Kim. 2017. Whole genome detection of signature of positive selection in African cattle reveals selection for thermotolerance. Animal Science Journal 88(12): 1889–1901en
dcterms.extentp. 1889-1901en
dcterms.issued2017-12
dcterms.languageen
dcterms.licenseCopyrighted; all rights reserved
dcterms.publisherWileyen
dcterms.subjectcattleen
dcterms.subjectlivestocken
dcterms.subjectgenomesen
dcterms.subjectresearchen
dcterms.typeJournal Article

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