The genome and GeneBank genomics of allotetraploid Nicotiana tabacum provide insights into genome evolution and complex trait regulation

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cg.authorship.typesCGIAR and developing country instituteen
cg.authorship.typesCGIAR and advanced research instituteen
cg.contributor.affiliationChinese Academy of Agricultural Sciencesen
cg.contributor.affiliationSichuan Universityen
cg.contributor.affiliationChinese Academy of Sciencesen
cg.contributor.affiliationChina National Botanical Gardenen
cg.contributor.affiliationUniversity of Chinese Academy of Sciencesen
cg.contributor.affiliationUmeå Universityen
cg.contributor.affiliationCAAS-IRRI Joint Laboratory for Genomics-assisted Germplasm Enhancementen
cg.contributor.affiliationInternational Rice Research Instituteen
cg.contributor.affiliationAarhus Universityen
cg.contributor.affiliationBeijing Life Science Academyen
cg.contributor.donorTaishan Young Scholar Programen
cg.contributor.donorNational Science Foundation of Chinaen
cg.contributor.donorChinese Academy Agriculture Sciencesen
cg.contributor.donorMinistry of Agriculture and Rural Affairs of the People’s Republic of Chinaen
cg.contributor.donorNational Science and Technology Resource Sharing Service Platformen
cg.coverage.countryChina
cg.coverage.iso3166-alpha2CN
cg.coverage.regionAsia
cg.coverage.regionEastern Asia
cg.creator.identifierGuoyou Ye: 0000-0002-9943-4815en
cg.edition2025en
cg.howPublishedFormally Publisheden
cg.identifier.doihttps://doi.org/10.1038/s41588-025-02126-0en
cg.identifier.urlhttps://www.nature.com/articles/s41588-025-02126-0#author-informationen
cg.isijournalISI Journalen
cg.issn1061-4036en
cg.journalNature Geneticsen
cg.reviewStatusPeer Reviewen
dc.contributor.authorZan, Yanjunen
dc.contributor.authorChen, Shuaien
dc.contributor.authorRen, Minen
dc.contributor.authorLiu, Guoxiangen
dc.contributor.authorLiu, Yutongen
dc.contributor.authorHan, Yuen
dc.contributor.authorDong, Yangen
dc.contributor.authorZhang, Yaoen
dc.contributor.authorSi, Huanen
dc.contributor.authorLiu, Zhengwenen
dc.contributor.authorLiu, Danen
dc.contributor.authorZhang, Xingweien
dc.contributor.authorTong, Yingen
dc.contributor.authorLi, Yuanen
dc.contributor.authorJiang, Caihongen
dc.contributor.authorWen, Liuyingen
dc.contributor.authorXiao, Zhiliangen
dc.contributor.authorSun, Yangyangen
dc.contributor.authorGeng, Ruimeien
dc.contributor.authorJi, Yanen
dc.contributor.authorFeng, Quanfuen
dc.contributor.authorWang, Yuanyingen
dc.contributor.authorYe, Guoyouen
dc.contributor.authorFang, Lingzhaoen
dc.contributor.authorChen, Yongen
dc.contributor.authorCheng, Liruien
dc.contributor.authorYang, Aiguoen
dc.date.accessioned2025-05-07T08:48:24Zen
dc.date.available2025-05-07T08:48:24Zen
dc.identifier.urihttps://hdl.handle.net/10568/174451
dc.titleThe genome and GeneBank genomics of allotetraploid Nicotiana tabacum provide insights into genome evolution and complex trait regulationen
dcterms.abstractNicotiana tabacum is an allotetraploid hybrid of Nicotiana sylvestris and Nicotiana tomentosiformis and a model organism in genetics. However, features of subgenome evolution, expression coordination, genetic diversity and complex traits regulation of N. tabacum remain unresolved. Here we present chromosome-scale assemblies for all three species, and genotype and phenotypic data for 5,196 N. tabacum germplasms. Chromosome rearrangements and epigenetic modifications are associated with genome evolution and expression coordination following polyploidization. Two subgenomes and genes biased toward one subgenome contributed unevenly to complex trait variation. Using 178 marker–trait associations, a reference genotype-to-phenotype map was built for 39 morphological, developmental and disease resistance traits, and a novel gene regulating leaf width was validated. Signatures of positive and polygenic selection during the process of selective breeding were detected. Our study provides insights into genome evolution, complex traits regulation in allotetraploid N. tabacum and the use of GeneBank-scale resources for advancing genetic and genomic research.en
dcterms.accessRightsOpen Access
dcterms.audienceCGIARen
dcterms.audienceDevelopment Practitionersen
dcterms.audiencePolicy Makersen
dcterms.audienceScientistsen
dcterms.bibliographicCitationZan, Yanjun, Shuai Chen, Min Ren, Guoxiang Liu, Yutong Liu, Yu Han, Yang Dong et al. "The genome and GeneBank genomics of allotetraploid Nicotiana tabacum provide insights into genome evolution and complex trait regulation." Nature Genetics (2025): 1-11.en
dcterms.extent20 p.en
dcterms.issued2025-03-26en
dcterms.languageen
dcterms.licenseCC-BY-NC-ND-4.0
dcterms.publisherSpringer Science and Business Media LLCen
dcterms.subjectNicotiana tabacumen
dcterms.subjectpolyploidyen
dcterms.subjectchromosomesen
dcterms.subjectepigeneticsen
dcterms.subjectgene expressionen
dcterms.subjectgenetic diversityen
dcterms.subjectquantitative trait locien
dcterms.subjectgenetic markersen
dcterms.typeJournal Article

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