Aflatoxins and fumonisins co-contamination effects on laying hens and use of mycotoxin detoxifiers as a mitigation strategy

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cg.authorship.typesCGIAR and developing country instituteen
cg.authorship.typesCGIAR and advanced research instituteen
cg.authorship.typesConsultanten
cg.contributor.affiliationUniversity of Liègeen
cg.contributor.affiliationGhent Universityen
cg.contributor.affiliationChuka Universityen
cg.contributor.affiliationUniversity of Nairobien
cg.contributor.affiliationBIOMIN Holding GmbHen
cg.contributor.affiliationInternational Livestock Research Instituteen
cg.contributor.affiliationUppsala Universityen
cg.contributor.affiliationSwedish University of Agricultural Sciencesen
cg.contributor.donorUppsala Universityen
cg.contributor.donorMinistry of Education, Science and Technology, Kenyaen
cg.contributor.donorBelgian National Fund for Scientific Researchen
cg.contributor.donorBelgian Science Policy Officeen
cg.contributor.donorResearch Council of Norwayen
cg.contributor.donorNational Research Foundation, South Africaen
cg.contributor.donorBIOMIN Holding GmbHen
cg.contributor.donorHarbro Ltd.en
cg.contributor.donorResearch Foundation Flandersen
cg.creator.identifierJohanna Lindahl: 0000-0002-1175-0398
cg.howPublishedFormally Publisheden
cg.identifier.doihttps://doi.org/10.1007/s12550-024-00566-xen
cg.isijournalISI Journalen
cg.issn0178-7888en
cg.issue1en
cg.journalMycotoxin Researchen
cg.reviewStatusPeer Reviewen
cg.subject.ilriAFLATOXINSen
cg.subject.ilriFOOD SAFETYen
cg.subject.ilriPOULTRYen
cg.subject.impactAreaNutrition, health and food security
cg.subject.sdgSDG 2 - Zero hungeren
cg.volume41en
dc.contributor.authorOchieng, P.E.en
dc.contributor.authorKemboi, D.C.en
dc.contributor.authorOkoth, S.en
dc.contributor.authorDe Baere, S.en
dc.contributor.authorCavalier, E.en
dc.contributor.authorKang’ethe, Erastus K.en
dc.contributor.authorDoupovec, B.en
dc.contributor.authorGathumbi, J.en
dc.contributor.authorScippo, M.-L.en
dc.contributor.authorAntonissen, G.en
dc.contributor.authorLindahl, Johanna F.en
dc.contributor.authorCroubels, S.en
dc.date.accessioned2024-10-17T17:17:49Zen
dc.date.available2024-10-17T17:17:49Zen
dc.identifier.urihttps://hdl.handle.net/10568/155404
dc.titleAflatoxins and fumonisins co-contamination effects on laying hens and use of mycotoxin detoxifiers as a mitigation strategyen
dcterms.abstractThis study examined the effects of fumonisins (FBs) and aflatoxin B1 (AFB1), alone or in combination, on the productivity and health of laying hens, as well as the transfer of aflatoxins (AFs) to chicken food products. The efficacy and safety of mycotoxin detoxifiers (bentonite and fumonisin esterase) to mitigate these effects were also assessed. Laying hens (400) were divided into 20 groups and fed a control, moderate (54.6 µg/kg feed) or high (546 µg/kg feed) AFB1 or FBs (7.9 mg/kg feed) added diets, either alone or in combination, with the mycotoxin detoxifiers added in selected diets. Productivity was evaluated by feed intake, egg weight, egg production, and feed conversion ratio whereas health was assessed by organ weights, blood biochemistry, and mortality. Aflatoxins residues in plasma, liver, muscle, and eggs were determined using UHPLC-MS/MS methods. A diet with AFB1 at a concentration of 546 µg/kg feed decreased egg production and various AFB1-contaminated diets increased serum uric acid levels and weights of liver, spleen, heart, and gizzard. Interactions between AFB1 and FBs significantly impacted spleen, heart, and gizzard weights as well as AFB1 residues in eggs. Maximum AFB1 residues of 0.64 µg/kg and aflatoxin M1 (below limits of quantification) were observed in liver, plasma, and eggs of layers fed diets with AFB1. The mycotoxin detoxifiers reduced effects of AFB1 and FBs on egg production, organ weights, blood biochemistry, and AFB1 residues in tissues. This study highlights the importance of mycotoxin detoxifiers as a mitigation strategy against mycotoxins in poultry production.en
dcterms.accessRightsOpen Access
dcterms.audienceAcademicsen
dcterms.audienceScientistsen
dcterms.available2024-10-15
dcterms.bibliographicCitationOchieng, P.E., Kemboi, D.C., Okoth, S., De Baere, S., Cavalier, E., Kang’ethe, E., Doupovec, B., Gathumbi, J., Scippo, M.-L., Antonissen, G., Lindahl, J.F. and Croubels, S. 2025. Aflatoxins and fumonisins co-contamination effects on laying hens and use of mycotoxin detoxifiers as a mitigation strategy. Mycotoxin Research 41(1): 63–75.en
dcterms.extentp. 63–75en
dcterms.issued2025-02
dcterms.languageen
dcterms.licenseCC-BY-4.0
dcterms.publisherSpringer Science and Business Media LLCen
dcterms.subjectaflatoxinsen
dcterms.subjectfood safetyen
dcterms.subjectpoultryen
dcterms.typeJournal Article

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