Aflatoxins and fumonisins co-contamination effects on laying hens and use of mycotoxin detoxifiers as a mitigation strategy

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cg.authorship.typesCGIAR and developing country instituteen_US
cg.authorship.typesCGIAR and advanced research instituteen_US
cg.authorship.typesConsultanten_US
cg.contributor.affiliationUniversity of Liègeen_US
cg.contributor.affiliationGhent Universityen_US
cg.contributor.affiliationChuka Universityen_US
cg.contributor.affiliationUniversity of Nairobien_US
cg.contributor.affiliationBIOMIN Holding GmbHen_US
cg.contributor.affiliationInternational Livestock Research Instituteen_US
cg.contributor.affiliationUppsala Universityen_US
cg.contributor.affiliationSwedish University of Agricultural Sciencesen_US
cg.contributor.donorUppsala Universityen_US
cg.contributor.donorMinistry of Education, Science and Technology, Kenyaen_US
cg.contributor.donorBelgian National Fund for Scientific Researchen_US
cg.contributor.donorBelgian Science Policy Officeen_US
cg.contributor.donorResearch Council of Norwayen_US
cg.contributor.donorNational Research Foundation, South Africaen_US
cg.contributor.donorBIOMIN Holding GmbHen_US
cg.contributor.donorHarbro Ltd.en_US
cg.contributor.donorResearch Foundation Flandersen_US
cg.creator.identifierJohanna Lindahl: 0000-0002-1175-0398en_US
cg.howPublishedFormally Publisheden_US
cg.identifier.doihttps://doi.org/10.1007/s12550-024-00566-xen_US
cg.isijournalISI Journalen_US
cg.issn0178-7888en_US
cg.issue1en_US
cg.journalMycotoxin Researchen_US
cg.reviewStatusPeer Reviewen_US
cg.subject.ilriAFLATOXINSen_US
cg.subject.ilriFOOD SAFETYen_US
cg.subject.ilriPOULTRYen_US
cg.subject.impactAreaNutrition, health and food securityen_US
cg.subject.sdgSDG 2 - Zero hungeren_US
cg.volume41en_US
dc.contributor.authorOchieng, P.E.en_US
dc.contributor.authorKemboi, D.C.en_US
dc.contributor.authorOkoth, S.en_US
dc.contributor.authorDe Baere, S.en_US
dc.contributor.authorCavalier, E.en_US
dc.contributor.authorKang’ethe, Erastus K.en_US
dc.contributor.authorDoupovec, B.en_US
dc.contributor.authorGathumbi, J.en_US
dc.contributor.authorScippo, M.-L.en_US
dc.contributor.authorAntonissen, G.en_US
dc.contributor.authorLindahl, Johanna F.en_US
dc.contributor.authorCroubels, S.en_US
dc.date.accessioned2024-10-17T17:17:49Zen_US
dc.date.available2024-10-17T17:17:49Zen_US
dc.identifier.urihttps://hdl.handle.net/10568/155404en_US
dc.titleAflatoxins and fumonisins co-contamination effects on laying hens and use of mycotoxin detoxifiers as a mitigation strategyen_US
dcterms.abstractThis study examined the effects of fumonisins (FBs) and aflatoxin B1 (AFB1), alone or in combination, on the productivity and health of laying hens, as well as the transfer of aflatoxins (AFs) to chicken food products. The efficacy and safety of mycotoxin detoxifiers (bentonite and fumonisin esterase) to mitigate these effects were also assessed. Laying hens (400) were divided into 20 groups and fed a control, moderate (54.6 µg/kg feed) or high (546 µg/kg feed) AFB1 or FBs (7.9 mg/kg feed) added diets, either alone or in combination, with the mycotoxin detoxifiers added in selected diets. Productivity was evaluated by feed intake, egg weight, egg production, and feed conversion ratio whereas health was assessed by organ weights, blood biochemistry, and mortality. Aflatoxins residues in plasma, liver, muscle, and eggs were determined using UHPLC-MS/MS methods. A diet with AFB1 at a concentration of 546 µg/kg feed decreased egg production and various AFB1-contaminated diets increased serum uric acid levels and weights of liver, spleen, heart, and gizzard. Interactions between AFB1 and FBs significantly impacted spleen, heart, and gizzard weights as well as AFB1 residues in eggs. Maximum AFB1 residues of 0.64 µg/kg and aflatoxin M1 (below limits of quantification) were observed in liver, plasma, and eggs of layers fed diets with AFB1. The mycotoxin detoxifiers reduced effects of AFB1 and FBs on egg production, organ weights, blood biochemistry, and AFB1 residues in tissues. This study highlights the importance of mycotoxin detoxifiers as a mitigation strategy against mycotoxins in poultry production.en_US
dcterms.accessRightsOpen Accessen_US
dcterms.audienceAcademicsen_US
dcterms.audienceScientistsen_US
dcterms.available2024-10-15en_US
dcterms.bibliographicCitationOchieng, P.E., Kemboi, D.C., Okoth, S., De Baere, S., Cavalier, E., Kang’ethe, E., Doupovec, B., Gathumbi, J., Scippo, M.-L., Antonissen, G., Lindahl, J.F. and Croubels, S. 2025. Aflatoxins and fumonisins co-contamination effects on laying hens and use of mycotoxin detoxifiers as a mitigation strategy. Mycotoxin Research 41(1): 63–75.en_US
dcterms.extentp. 63–75en_US
dcterms.issued2025-02en_US
dcterms.languageenen_US
dcterms.licenseCC-BY-4.0en_US
dcterms.publisherSpringer Science and Business Media LLCen_US
dcterms.subjectaflatoxinsen_US
dcterms.subjectfood safetyen_US
dcterms.subjectpoultryen_US
dcterms.typeJournal Articleen_US

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