Functional evolution of the colony‐stimulating factor 1 receptor (CSF1R) and its ligands in birds

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cg.authorship.typesCGIAR and developing country instituteen_US
cg.authorship.typesCGIAR and advanced research instituteen_US
cg.contributor.affiliationUniversity of Queenslanden_US
cg.contributor.affiliationUniversity of Edinburghen_US
cg.contributor.affiliationUniversidad Automona del Estado de Mexicoen_US
cg.contributor.affiliationAddis Ababa Universityen_US
cg.contributor.affiliationAmhara Regional Agricultural Research Institute, Ethiopiaen_US
cg.contributor.affiliationInternational Livestock Research Instituteen_US
cg.contributor.affiliationUniversity of Nottinghamen_US
cg.contributor.crpLivestocken_US
cg.contributor.donorBill & Melinda Gates Foundationen_US
cg.contributor.donorDepartment for International Development, United Kingdomen_US
cg.howPublishedFormally Publisheden_US
cg.identifier.doihttps://doi.org/10.1002/jlb.6ma0519-172ren_US
cg.isijournalISI Journalen_US
cg.issn1938-3673en_US
cg.issue2en_US
cg.journalJournal of Leukocyte Biologyen_US
cg.reviewStatusPeer Reviewen_US
cg.subject.ilriANIMAL BREEDINGen_US
cg.subject.ilriGENETICSen_US
cg.volume107en_US
dc.contributor.authorHume, D.A.en_US
dc.contributor.authorGutowska‐Ding, M.W.en_US
dc.contributor.authorGarcia‐Morales, C.en_US
dc.contributor.authorKebede, A.en_US
dc.contributor.authorBamidele, Oladejien_US
dc.contributor.authorTrujillo, A.V.en_US
dc.contributor.authorGheyas, Almas A.en_US
dc.contributor.authorSmith, J.en_US
dc.date.accessioned2020-08-20T19:09:55Zen_US
dc.date.available2020-08-20T19:09:55Zen_US
dc.identifier.urihttps://hdl.handle.net/10568/109044en_US
dc.titleFunctional evolution of the colony‐stimulating factor 1 receptor (CSF1R) and its ligands in birdsen_US
dcterms.abstractMacrophage colony-stimulating factor (CSF1 or M-CSF) and interleukin 34 (IL34) are secreted cytokines that control macrophage survival and differentiation. Both act through the CSF1 receptor (CSF1R), a type III transmembrane receptor tyrosine kinase. The functions of CSF1R and both ligands are conserved in birds. We have analyzed protein-coding sequence divergence among avian species. The intracellular tyrosine kinase domain of CSF1R was highly conserved in bird species as in mammals but the extracellular domain of avian CSF1R was more divergent in birds with multiple positively selected amino acids. Based upon crystal structures of the mammalian CSF1/IL34 receptor-ligand interfaces and structure-based alignments, we identified amino acids involved in avian receptor-ligand interactions. The contact amino acids in both CSF1 and CSF1R diverged among avian species. Ligand-binding domain swaps between chicken and zebra finch CSF1 confirmed the function of variants that confer species specificity on the interaction of CSF1 with CSF1R. Based upon genomic sequence analysis, we identified prevalent amino acid changes in the extracellular domain of CSF1R even within the chicken species that distinguished commercial broilers and layers and tropically adapted breeds. The rapid evolution in the extracellular domain of avian CSF1R suggests that at least in birds this ligand-receptor interaction is subjected to pathogen selection. We discuss this finding in the context of expression of CSF1R in antigen-sampling and antigen-presenting cells.en_US
dcterms.accessRightsOpen Accessen_US
dcterms.audienceScientistsen_US
dcterms.available2019-09-05en_US
dcterms.bibliographicCitationHume, D.A., Gutowska‐Ding, M.W., Garcia‐Morales, C., Kebede, A., Bamidele, O., Trujillo, A.V., Gheyas, A.A. and Smith, J. 2020. Functional evolution of the colony‐stimulating factor 1 receptor (CSF1R) and its ligands in birds. Journal of Leukocyte Biology 107(2):237-250.en_US
dcterms.extentp. 237-250en_US
dcterms.issued2020-02-01en_US
dcterms.languageenen_US
dcterms.licenseCC-BY-4.0en_US
dcterms.publisherOxford University Pressen_US
dcterms.subjectbirdsen_US
dcterms.subjectgeneticsen_US
dcterms.subjectanimal breedingen_US
dcterms.subjectcell biologyen_US
dcterms.subjectimmunologyen_US
dcterms.typeJournal Articleen_US

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