Functional evolution of the colony‐stimulating factor 1 receptor (CSF1R) and its ligands in birds

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cg.authorship.typesCGIAR and developing country instituteen
cg.authorship.typesCGIAR and advanced research instituteen
cg.contributor.affiliationUniversity of Queenslanden
cg.contributor.affiliationUniversity of Edinburghen
cg.contributor.affiliationUniversidad Automona del Estado de Mexicoen
cg.contributor.affiliationAddis Ababa Universityen
cg.contributor.affiliationAmhara Regional Agricultural Research Institute, Ethiopiaen
cg.contributor.affiliationInternational Livestock Research Instituteen
cg.contributor.affiliationUniversity of Nottinghamen
cg.contributor.crpLivestock
cg.contributor.donorBill & Melinda Gates Foundationen
cg.contributor.donorDepartment for International Development, United Kingdomen
cg.howPublishedFormally Publisheden
cg.identifier.doihttps://doi.org/10.1002/jlb.6ma0519-172ren
cg.isijournalISI Journalen
cg.issn1938-3673en
cg.issue2en
cg.journalJournal of Leukocyte Biologyen
cg.reviewStatusPeer Reviewen
cg.subject.ilriANIMAL BREEDINGen
cg.subject.ilriGENETICSen
cg.volume107en
dc.contributor.authorHume, D.A.en
dc.contributor.authorGutowska‐Ding, M.W.en
dc.contributor.authorGarcia‐Morales, C.en
dc.contributor.authorKebede, A.en
dc.contributor.authorBamidele, Oladejien
dc.contributor.authorTrujillo, A.V.en
dc.contributor.authorGheyas, Almas A.en
dc.contributor.authorSmith, J.en
dc.date.accessioned2020-08-20T19:09:55Zen
dc.date.available2020-08-20T19:09:55Zen
dc.identifier.urihttps://hdl.handle.net/10568/109044
dc.titleFunctional evolution of the colony‐stimulating factor 1 receptor (CSF1R) and its ligands in birdsen
dcterms.abstractMacrophage colony-stimulating factor (CSF1 or M-CSF) and interleukin 34 (IL34) are secreted cytokines that control macrophage survival and differentiation. Both act through the CSF1 receptor (CSF1R), a type III transmembrane receptor tyrosine kinase. The functions of CSF1R and both ligands are conserved in birds. We have analyzed protein-coding sequence divergence among avian species. The intracellular tyrosine kinase domain of CSF1R was highly conserved in bird species as in mammals but the extracellular domain of avian CSF1R was more divergent in birds with multiple positively selected amino acids. Based upon crystal structures of the mammalian CSF1/IL34 receptor-ligand interfaces and structure-based alignments, we identified amino acids involved in avian receptor-ligand interactions. The contact amino acids in both CSF1 and CSF1R diverged among avian species. Ligand-binding domain swaps between chicken and zebra finch CSF1 confirmed the function of variants that confer species specificity on the interaction of CSF1 with CSF1R. Based upon genomic sequence analysis, we identified prevalent amino acid changes in the extracellular domain of CSF1R even within the chicken species that distinguished commercial broilers and layers and tropically adapted breeds. The rapid evolution in the extracellular domain of avian CSF1R suggests that at least in birds this ligand-receptor interaction is subjected to pathogen selection. We discuss this finding in the context of expression of CSF1R in antigen-sampling and antigen-presenting cells.en
dcterms.accessRightsOpen Access
dcterms.audienceScientistsen
dcterms.available2019-09-05en
dcterms.bibliographicCitationHume, D.A., Gutowska‐Ding, M.W., Garcia‐Morales, C., Kebede, A., Bamidele, O., Trujillo, A.V., Gheyas, A.A. and Smith, J. 2020. Functional evolution of the colony‐stimulating factor 1 receptor (CSF1R) and its ligands in birds. Journal of Leukocyte Biology 107(2):237-250.en
dcterms.extentp. 237-250en
dcterms.issued2020-02-01en
dcterms.languageen
dcterms.licenseCC-BY-4.0
dcterms.publisherOxford University Pressen
dcterms.subjectbirdsen
dcterms.subjectgeneticsen
dcterms.subjectanimal breedingen
dcterms.subjectcell biologyen
dcterms.subjectimmunologyen
dcterms.typeJournal Article

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