Determinants of vitamin D status in Kenyan calves
cg.authorship.types | CGIAR and advanced research institute | en_US |
cg.contributor.affiliation | University of Edinburgh | en_US |
cg.contributor.affiliation | International Livestock Research Institute | en_US |
cg.contributor.affiliation | Centre for Tropical Livestock Genetics and Health | en_US |
cg.contributor.crp | Livestock | en_US |
cg.contributor.donor | Bill & Melinda Gates Foundation | en_US |
cg.contributor.donor | Department for International Development, United Kingdom | en_US |
cg.contributor.donor | Wellcome Trust | en_US |
cg.contributor.donor | Biotechnology and Biological Sciences Research Council, United Kingdom | en_US |
cg.coverage.country | Kenya | en_US |
cg.coverage.iso3166-alpha2 | KE | en_US |
cg.coverage.region | Africa | en_US |
cg.coverage.region | Eastern Africa | en_US |
cg.creator.identifier | Philip Toye: 0000-0002-7100-2789 | en_US |
cg.creator.identifier | Mark Bronsvoort: 0000-0002-3271-8485 | en_US |
cg.howPublished | Formally Published | en_US |
cg.identifier.doi | https://doi.org/10.1038/s41598-020-77209-5 | en_US |
cg.isijournal | ISI Journal | en_US |
cg.issn | 2045-2322 | en_US |
cg.issue | 1 | en_US |
cg.journal | Scientific Reports | en_US |
cg.reviewStatus | Peer Review | en_US |
cg.subject.ilri | ANIMAL DISEASES | en_US |
cg.subject.ilri | ANIMAL HEALTH | en_US |
cg.subject.ilri | LIVESTOCK | en_US |
cg.subject.ilri | CATTLE | en_US |
cg.volume | 10 | en_US |
dc.contributor.author | Callaby, R. | en_US |
dc.contributor.author | Hurst, E. | en_US |
dc.contributor.author | Handel, Ian G. | en_US |
dc.contributor.author | Toye, Philip G. | en_US |
dc.contributor.author | Bronsvoort, B.M. de C. | en_US |
dc.contributor.author | Mellanby, R.J. | en_US |
dc.date.accessioned | 2020-11-30T12:40:56Z | en_US |
dc.date.available | 2020-11-30T12:40:56Z | en_US |
dc.identifier.uri | https://hdl.handle.net/10568/110355 | en_US |
dc.title | Determinants of vitamin D status in Kenyan calves | en_US |
dcterms.abstract | Vitamin D plays a critical role in calcium homeostasis and in the maintenance and development of skeletal health. Vitamin D status has increasingly been linked to non-skeletal health outcomes such as all-cause mortality, infectious diseases and reproductive outcomes in both humans and veterinary species. We have previously demonstrated a relationship between vitamin D status, assessed by the measurement of serum concentrations of the major vitamin D metabolite 25 hydroxyvitamin D (25(OH)D), and a wide range of non-skeletal health outcomes in companion and wild animals. The aims of this study were to define the host and environmental factors associated with vitamin D status in a cohort of 527 calves from Western Kenya which were part of the Infectious Disease of East African Livestock (IDEAL) cohort. A secondary aim was to explore the relationship between serum 25(OH)D concentrations measured in 7-day old calves and subsequent health outcomes over the following 12 months. A genome wide association study demonstrated that both dietary and endogenously produced vitamin D metabolites were under polygenic control in African calves. In addition, we found that neonatal vitamin D status was not predictive of the subsequent development of an infectious disease event or mortality over the 12 month follow up period. | en_US |
dcterms.accessRights | Open Access | en_US |
dcterms.audience | Scientists | en_US |
dcterms.available | 2020-11-25 | en_US |
dcterms.bibliographicCitation | Callaby, R., Hurst, E., Handel, I., Toye, P., Bronsvoort, B.M. de C. and Mellanby, R.J. 2020. Determinants of vitamin D status in Kenyan calves. Scientific Reports 10:20590 | en_US |
dcterms.issued | 2020-11-25 | en_US |
dcterms.language | en | en_US |
dcterms.license | CC-BY-4.0 | en_US |
dcterms.publisher | Springer | en_US |
dcterms.subject | animal diseases | en_US |
dcterms.subject | animal health | en_US |
dcterms.subject | infectious diseases | en_US |
dcterms.subject | calves | en_US |
dcterms.subject | livestock | en_US |
dcterms.type | Journal Article | en_US |
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