Determinants of vitamin D status in Kenyan calves

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cg.authorship.typesCGIAR and advanced research instituteen
cg.contributor.affiliationUniversity of Edinburghen
cg.contributor.affiliationInternational Livestock Research Instituteen
cg.contributor.affiliationCentre for Tropical Livestock Genetics and Healthen
cg.contributor.crpLivestock
cg.contributor.donorBill & Melinda Gates Foundationen
cg.contributor.donorDepartment for International Development, United Kingdomen
cg.contributor.donorWellcome Trusten
cg.contributor.donorBiotechnology and Biological Sciences Research Council, United Kingdomen
cg.coverage.countryKenya
cg.coverage.iso3166-alpha2KE
cg.coverage.regionAfrica
cg.coverage.regionEastern Africa
cg.creator.identifierPhilip Toye: 0000-0002-7100-2789
cg.creator.identifierMark Bronsvoort: 0000-0002-3271-8485
cg.howPublishedFormally Publisheden
cg.identifier.doihttps://doi.org/10.1038/s41598-020-77209-5en
cg.isijournalISI Journalen
cg.issn2045-2322en
cg.issue1en
cg.journalScientific Reportsen
cg.reviewStatusPeer Reviewen
cg.subject.ilriANIMAL DISEASESen
cg.subject.ilriANIMAL HEALTHen
cg.subject.ilriLIVESTOCKen
cg.subject.ilriCATTLEen
cg.volume10en
dc.contributor.authorCallaby, R.en
dc.contributor.authorHurst, E.en
dc.contributor.authorHandel, Ian G.en
dc.contributor.authorToye, Philip G.en
dc.contributor.authorBronsvoort, B.M. de C.en
dc.contributor.authorMellanby, R.J.en
dc.date.accessioned2020-11-30T12:40:56Zen
dc.date.available2020-11-30T12:40:56Zen
dc.identifier.urihttps://hdl.handle.net/10568/110355
dc.titleDeterminants of vitamin D status in Kenyan calvesen
dcterms.abstractVitamin D plays a critical role in calcium homeostasis and in the maintenance and development of skeletal health. Vitamin D status has increasingly been linked to non-skeletal health outcomes such as all-cause mortality, infectious diseases and reproductive outcomes in both humans and veterinary species. We have previously demonstrated a relationship between vitamin D status, assessed by the measurement of serum concentrations of the major vitamin D metabolite 25 hydroxyvitamin D (25(OH)D), and a wide range of non-skeletal health outcomes in companion and wild animals. The aims of this study were to define the host and environmental factors associated with vitamin D status in a cohort of 527 calves from Western Kenya which were part of the Infectious Disease of East African Livestock (IDEAL) cohort. A secondary aim was to explore the relationship between serum 25(OH)D concentrations measured in 7-day old calves and subsequent health outcomes over the following 12 months. A genome wide association study demonstrated that both dietary and endogenously produced vitamin D metabolites were under polygenic control in African calves. In addition, we found that neonatal vitamin D status was not predictive of the subsequent development of an infectious disease event or mortality over the 12 month follow up period.en
dcterms.accessRightsOpen Access
dcterms.audienceScientistsen
dcterms.available2020-11-25
dcterms.bibliographicCitationCallaby, R., Hurst, E., Handel, I., Toye, P., Bronsvoort, B.M. de C. and Mellanby, R.J. 2020. Determinants of vitamin D status in Kenyan calves. Scientific Reports 10:20590en
dcterms.issued2020-11-25
dcterms.languageen
dcterms.licenseCC-BY-4.0
dcterms.publisherSpringeren
dcterms.subjectanimal diseasesen
dcterms.subjectanimal healthen
dcterms.subjectinfectious diseasesen
dcterms.subjectcalvesen
dcterms.subjectlivestocken
dcterms.typeJournal Article

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