Determinants of vitamin D status in Kenyan calves

Simple item page
cg.authorship.typesCGIAR and advanced research instituteen_US
cg.contributor.affiliationUniversity of Edinburghen_US
cg.contributor.affiliationInternational Livestock Research Instituteen_US
cg.contributor.affiliationCentre for Tropical Livestock Genetics and Healthen_US
cg.contributor.crpLivestocken_US
cg.contributor.donorBill & Melinda Gates Foundationen_US
cg.contributor.donorDepartment for International Development, United Kingdomen_US
cg.contributor.donorWellcome Trusten_US
cg.contributor.donorBiotechnology and Biological Sciences Research Council, United Kingdomen_US
cg.coverage.countryKenyaen_US
cg.coverage.iso3166-alpha2KEen_US
cg.coverage.regionAfricaen_US
cg.coverage.regionEastern Africaen_US
cg.creator.identifierPhilip Toye: 0000-0002-7100-2789en_US
cg.creator.identifierMark Bronsvoort: 0000-0002-3271-8485en_US
cg.howPublishedFormally Publisheden_US
cg.identifier.doihttps://doi.org/10.1038/s41598-020-77209-5en_US
cg.isijournalISI Journalen_US
cg.issn2045-2322en_US
cg.issue1en_US
cg.journalScientific Reportsen_US
cg.reviewStatusPeer Reviewen_US
cg.subject.ilriANIMAL DISEASESen_US
cg.subject.ilriANIMAL HEALTHen_US
cg.subject.ilriLIVESTOCKen_US
cg.subject.ilriCATTLEen_US
cg.volume10en_US
dc.contributor.authorCallaby, R.en_US
dc.contributor.authorHurst, E.en_US
dc.contributor.authorHandel, Ian G.en_US
dc.contributor.authorToye, Philip G.en_US
dc.contributor.authorBronsvoort, B.M. de C.en_US
dc.contributor.authorMellanby, R.J.en_US
dc.date.accessioned2020-11-30T12:40:56Zen_US
dc.date.available2020-11-30T12:40:56Zen_US
dc.identifier.urihttps://hdl.handle.net/10568/110355en_US
dc.titleDeterminants of vitamin D status in Kenyan calvesen_US
dcterms.abstractVitamin D plays a critical role in calcium homeostasis and in the maintenance and development of skeletal health. Vitamin D status has increasingly been linked to non-skeletal health outcomes such as all-cause mortality, infectious diseases and reproductive outcomes in both humans and veterinary species. We have previously demonstrated a relationship between vitamin D status, assessed by the measurement of serum concentrations of the major vitamin D metabolite 25 hydroxyvitamin D (25(OH)D), and a wide range of non-skeletal health outcomes in companion and wild animals. The aims of this study were to define the host and environmental factors associated with vitamin D status in a cohort of 527 calves from Western Kenya which were part of the Infectious Disease of East African Livestock (IDEAL) cohort. A secondary aim was to explore the relationship between serum 25(OH)D concentrations measured in 7-day old calves and subsequent health outcomes over the following 12 months. A genome wide association study demonstrated that both dietary and endogenously produced vitamin D metabolites were under polygenic control in African calves. In addition, we found that neonatal vitamin D status was not predictive of the subsequent development of an infectious disease event or mortality over the 12 month follow up period.en_US
dcterms.accessRightsOpen Accessen_US
dcterms.audienceScientistsen_US
dcterms.available2020-11-25en_US
dcterms.bibliographicCitationCallaby, R., Hurst, E., Handel, I., Toye, P., Bronsvoort, B.M. de C. and Mellanby, R.J. 2020. Determinants of vitamin D status in Kenyan calves. Scientific Reports 10:20590en_US
dcterms.issued2020-11-25en_US
dcterms.languageenen_US
dcterms.licenseCC-BY-4.0en_US
dcterms.publisherSpringeren_US
dcterms.subjectanimal diseasesen_US
dcterms.subjectanimal healthen_US
dcterms.subjectinfectious diseasesen_US
dcterms.subjectcalvesen_US
dcterms.subjectlivestocken_US
dcterms.typeJournal Articleen_US

Files

License bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.75 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

ILRI articles in journals
CRP Livestock journal articles
ILRI livestock genetics program outputs