Genome-wide association study for the level of prolificacy in Cameroon’s native goat

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cg.contributor.affiliationBahir Dar Universityen_US
cg.contributor.affiliationInternational Livestock Research Instituteen_US
cg.contributor.affiliationLilongwe University of Agriculture and Natural Resourcesen_US
cg.contributor.affiliationSwedish University of Agricultural Sciencesen_US
cg.contributor.affiliationUniversity of Dschangen_US
cg.contributor.donorSwedish Ministry for Foreign Affairs through the Swedish International Development Agency (Sida) through the Goat Projecten_US
cg.coverage.countryCameroonen_US
cg.coverage.iso3166-alpha2CMen_US
cg.coverage.regionMiddle Africaen_US
cg.creator.identifierRoger Pelle: 0000-0003-1053-085Xen_US
cg.creator.identifierAppolinaire Djikeng: 0000-0001-9271-3419en_US
cg.identifier.doihttps://doi.org/10.1080/09712119.2023.2291472en_US
cg.isijournalISI Journalen_US
cg.issn0971-2119en_US
cg.issn0974-1844en_US
cg.issue1en_US
cg.journalJournal of Applied Animal Researchen_US
cg.volume52en_US
dc.contributor.authorKouam Simo, Jauresen_US
dc.contributor.authorMeutchieye, Felixen_US
dc.contributor.authorWouobeng, Patricken_US
dc.contributor.authorTarekegn, Getinet Mekuriawen_US
dc.contributor.authorMutai, Collinsen_US
dc.contributor.authorNandolo, Wilsonen_US
dc.contributor.authorPelle, Rogeren_US
dc.contributor.authorDjikeng, Appolinaireen_US
dc.contributor.authorManjeli, Yacoubaen_US
dc.date.accessioned2024-09-11T09:26:00Zen_US
dc.date.available2024-09-11T09:26:00Zen_US
dc.identifier.urihttps://hdl.handle.net/10568/152117en_US
dc.titleGenome-wide association study for the level of prolificacy in Cameroon’s native goaten_US
dcterms.abstractIncome from goats highly depends on prolificacy, which is difficult to improve by traditional breeding methods. The study aimed to identify SNP markers for prolificacy, using a case–control genome-wide association study (GWAS) on 111 genotyped Cameroon native goat (CNG) does, based on the 50 K single nucleotide polymorphism (SNP) chip panel. None of the top SNPs reached the significant p-value of 5 × 10−8. The highest p-value was 0.0009. Despite the number of cases being about a quarter of the number of controls, the highest allele frequency of some of the top 20 variants in the cases was indicative of their potential role in the trait. These top variants included the following 15: rs268285661, rs268235169, rs268236449, rs268235135, rs268240394 in Sphingosine-1-phosphate phosphatase 2 (SGPP2) gene, rs268283635 in Solute carrier family 24 member 2 (SLC24A2) gene, rs268251678 in Androgen-induced gene 1 (AIG1) gene, rs268267018, rs268239617, rs268281364, rs268273029, rs268286941, rs268236144, rs268233233 in CEP126 gene and rs268278159, respectively. Our findings indicate that GWAS enable the identification of some loci within genes, with known biological functions and pathways in human being and mice animal model but far-ranging to what was previously hypothesized and tested in goat.en_US
dcterms.accessRightsOpen Accessen_US
dcterms.available2024-01-24en_US
dcterms.bibliographicCitationKouam Simo, J., Meutchieye, F., Wouobeng, P., Tarekegn, G. M., Mutai, C., Nandolo, W., Pelle, R., Djikeng, A., & Manjeli, Y. (2024). Genome-wide association study for the level of prolificacy in Cameroon’s native goat. Journal of Applied Animal Research, 52(1). https://doi.org/10.1080/09712119.2023.2291472en_US
dcterms.issued2024-12-31en_US
dcterms.languageenen_US
dcterms.licenseCC-BY-NC-4.0en_US
dcterms.publisherInforma UK Limiteden_US
dcterms.subjectgenomeen_US
dcterms.typeJournal Articleen_US

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