Characterization of humoral and cellular immune responses elicited by reduced doses of Brucella abortus S19 (calfhood) vaccine in cattle calves of India

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cg.authorship.typesCGIAR and developing country instituteen_US
cg.contributor.affiliationIndian Council of Agricultural Researchen_US
cg.contributor.affiliationIntervet India Pvt. Ltd., Indiaen_US
cg.contributor.affiliationInternational Livestock Research Instituteen_US
cg.coverage.countryIndiaen_US
cg.coverage.iso3166-alpha2INen_US
cg.coverage.regionAsiaen_US
cg.coverage.regionSouthern Asiaen_US
cg.howPublishedFormally Publisheden_US
cg.identifier.doihttps://doi.org/10.1016/j.rvsc.2023.03.017en_US
cg.isijournalISI Journalen_US
cg.issn1532-2661en_US
cg.journalResearch in Veterinary Scienceen_US
cg.reviewStatusPeer Reviewen_US
cg.subject.ilriANIMAL DISEASESen_US
cg.subject.ilriCATTLEen_US
cg.subject.ilriDISEASE CONTROLen_US
cg.subject.ilriVACCINESen_US
cg.volume158en_US
dc.contributor.authorShome, R.en_US
dc.contributor.authorKilari, S.en_US
dc.contributor.authorSahare, A.en_US
dc.contributor.authorKalleshamurthy, T.en_US
dc.contributor.authorShome, B.R.en_US
dc.contributor.authorSkariah, S.en_US
dc.contributor.authorHiremath, J.en_US
dc.contributor.authorMisri, J.en_US
dc.contributor.authorRahman, Habibaren_US
dc.date.accessioned2023-05-10T09:15:47Zen_US
dc.date.available2023-05-10T09:15:47Zen_US
dc.identifier.urihttps://hdl.handle.net/10568/130303en_US
dc.titleCharacterization of humoral and cellular immune responses elicited by reduced doses of Brucella abortus S19 (calfhood) vaccine in cattle calves of Indiaen_US
dcterms.abstractBrucella abortus S19 vaccine is a stable attenuated smooth strain, globally used as calfhood vaccine for the prevention of bovine brucellosis. Various agencies demonstrated different doses for vaccinating cattle and buffalo calves leading to ambiguity in selecting a suitable immune vaccine dose. The current study aimed at evaluating four graded doses of S19 vaccine to arrive at the dose which could produce comparable effectiveness as that of full dose prescribed by Indian Pharmacopeia among the Indian calves. Four vaccine doses of which the first dose consisted of full dose (40 × 109 CFU/dose) and the other three were 1/10th, 1/20th, 1/100th reduced doses along with control were tested. Each vaccine dose was administered to 13 cattle calves of 4–5 months of age maintained in separate groups. The blood samples were collected on 0 to 240 days post-vaccination (DPV) at the intervals of 0, 14, 28, 45, 60, 90, 150, 180 and 240 for assessment of vaccine-induced innate, humoral and cell-mediated immune responses. The sero-conversion of all vaccinated animals on DPV 45 and persistence of antibody till DPV 240 were noticed. No significant differences were observed in antibody response between animal groups that received full and 1/10th reduced doses. Innate and cell-mediated response by IL-6, TNF-α¸ IFN-γ, CD4+ and CD8+ cell counts showed dose-dependent responses with no significant difference between full dose and 1/10th reduced doses. The results suggest a possible one log reduction of full dose without compromising immune responses to aid larger vaccination coverage for creating herd immunity.en_US
dcterms.accessRightsLimited Accessen_US
dcterms.audienceScientistsen_US
dcterms.bibliographicCitationShome, R., Kilari, S., Sahare, A., Kalleshamurthy, T., Shome, B.R., Skariah, S., Hiremath, J., Misri, J. and Rahman, H. 2023. Characterization of humoral and cellular immune responses elicited by reduced doses of Brucella abortus S19 (calfhood) vaccine in cattle calves of India. Research in Veterinary Science 158:124-133.en_US
dcterms.extentpp. 124-133en_US
dcterms.issued2023-05en_US
dcterms.languageenen_US
dcterms.licenseCopyrighted; all rights reserveden_US
dcterms.publisherElsevieren_US
dcterms.subjectbrucella abortusen_US
dcterms.subjectbrucellosisen_US
dcterms.subjectanimal diseasesen_US
dcterms.subjectvaccinesen_US
dcterms.subjectcattleen_US
dcterms.typeJournal Articleen_US

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