Modeling within and between sub-genomes epistasis of synthetic hexaploid wheat for genome-enabled prediction of diseases

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cg.authorship.typesCGIAR single centreen_US
cg.authorship.typesCGIAR and advanced research instituteen_US
cg.contributor.affiliationUniversidad Autónoma del Estado de Quintana Rooen_US
cg.contributor.affiliationInternational Maize and Wheat Improvement Centeren_US
cg.contributor.affiliationColegio de Postgraduados, Mexicoen_US
cg.contributor.donorBill & Melinda Gates Foundationen_US
cg.contributor.donorUnited States Agency for International Developmenten_US
cg.contributor.donorResearch Council of Norwayen_US
cg.contributor.donorCGIAR Trust Funden_US
cg.contributor.initiativeAccelerated Breedingen_US
cg.creator.identifierJaime Cuevas: 0000-0002-0685-2867en_US
cg.creator.identifierDavid González-Diéguez: 0000-0002-8637-1835en_US
cg.creator.identifierSusanne Dreisigacker: 0000-0002-3546-5989en_US
cg.creator.identifierJohannes Martini: 0000-0003-0628-6794en_US
cg.creator.identifierLeonardo Abdiel Crespo Herrera: 0000-0003-0506-4700en_US
cg.creator.identifierNerida Lozano-Ramírez: 0000-0002-2351-5432en_US
cg.creator.identifierPawan Singh: 0000-0003-4610-3120en_US
cg.creator.identifierXinyao He: 0000-0003-0217-9510en_US
cg.creator.identifierJULIO HUERTA-ESPINO: 0000-0001-8334-9862en_US
cg.creator.identifierJose Crossa: 0000-0001-9429-5855en_US
cg.howPublishedFormally Publisheden_US
cg.identifier.doihttps://doi.org/10.3390/genes15030262en_US
cg.isijournalISI Journalen_US
cg.issn2073-4425en_US
cg.issue3en_US
cg.journalGenesen_US
cg.reviewStatusPeer Reviewen_US
cg.subject.actionAreaGenetic Innovationen_US
cg.subject.impactAreaNutrition, health and food securityen_US
cg.volume15en_US
dc.contributor.authorCuevas, Jaimeen_US
dc.contributor.authorGonzález-Diéguez, David O.en_US
dc.contributor.authorDreisigacker, Susanneen_US
dc.contributor.authorMartini, Johannes W.R.en_US
dc.contributor.authorCrespo-Herrera, Leonardo A.en_US
dc.contributor.authorLozano-Ramirez, Neridaen_US
dc.contributor.authorSingh, Pawan Kumaren_US
dc.contributor.authorHe, Xinyaoen_US
dc.contributor.authorHuerta-Espino, Julioen_US
dc.contributor.authorCrossa, Joseen_US
dc.date.accessioned2024-04-15T21:47:23Zen_US
dc.date.available2024-04-15T21:47:23Zen_US
dc.identifier.urihttps://hdl.handle.net/10568/141473en_US
dc.titleModeling within and between sub-genomes epistasis of synthetic hexaploid wheat for genome-enabled prediction of diseasesen_US
dcterms.abstractCommon wheat (Triticum aestivum) is a hexaploid crop comprising three diploid sub-genomes labeled A, B, and D. The objective of this study is to investigate whether there is a discernible influence pattern from the D sub-genome with epistasis in genomic models for wheat diseases. Four genomic statistical models were employed; two models considered the linear genomic relationship of the lines. The first model (G) utilized all molecular markers, while the second model (ABD) utilized three matrices representing the A, B, and D sub-genomes. The remaining two models incorporated epistasis, one (GI) using all markers and the other (ABDI) considering markers in sub-genomes A, B, and D, including inter- and intra-sub-genome interactions. The data utilized pertained to three diseases: tan spot (TS), septoria nodorum blotch (SNB), and spot blotch (SB), for synthetic hexaploid wheat (SHW) lines. The results (variance components) indicate that epistasis makes a substantial contribution to explaining genomic variation, accounting for approximately 50% in SNB and SB and only 29% for TS. In this contribution of epistasis, the influence of intra- and inter-sub-genome interactions of the D sub-genome is crucial, being close to 50% in TS and higher in SNB (60%) and SB (60%). This increase in explaining genomic variation is reflected in an enhancement of predictive ability from the G model (additive) to the ABDI model (additive and epistasis) by 9%, 5%, and 1% for SNB, SB, and TS, respectively. These results, in line with other studies, underscore the significance of the D sub-genome in disease traits and suggest a potential application to be explored in the future regarding the selection of parental crosses based on sub-genomes.en_US
dcterms.accessRightsOpen Accessen_US
dcterms.audienceAcademicsen_US
dcterms.available2024-02-20en_US
dcterms.bibliographicCitationCuevas, J., González-Diéguez, D., Dreisigacker, S., Martini, J. W. R., Crespo-Herrera, L., Lozano-Ramirez, N., Singh, P. K., He, X., Huerta, J., & Crossa, J. (2024). Modeling within and between sub-genomes epistasis of synthetic hexaploid wheat for genome-enabled prediction of diseases. Genes, 15(3), 262. https://doi.org/10.3390/genes15030262en_US
dcterms.issued2024-02-20en_US
dcterms.languageenen_US
dcterms.licenseCC-BY-4.0en_US
dcterms.publisherMDPIen_US
dcterms.subjectgene interactionen_US
dcterms.subjecthexaploidyen_US
dcterms.subjectwheaten_US
dcterms.subjectforecastingen_US
dcterms.subjectgenomesen_US
dcterms.typeJournal Articleen_US

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