Detection of canine distemper virus (CDV) neutralising antibodies in small ruminants during peste-des-petits-ruminants virus (PPRV) surveillance in Zambia

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cg.authorship.typesCGIAR and developing country instituteen
cg.authorship.typesCGIAR and advanced research instituteen
cg.contributor.affiliationSwedish University of Agricultural Sciencesen
cg.contributor.affiliationInternational Livestock Research Instituteen
cg.contributor.affiliationUniversity of Glasgowen
cg.contributor.affiliationUppsala Universityen
cg.contributor.affiliationSwedish Veterinary Agencyen
cg.contributor.affiliationCentral Veterinary Research Institute, Zambiaen
cg.contributor.affiliationNational Livestock Epidemiology and Information Centre, Zambiaen
cg.contributor.affiliationUniversity of Zambiaen
cg.contributor.donorSwedish Research Councilen
cg.contributor.donorMichael Forsgren Foundationen
cg.contributor.donorSwedish University of Agricultural Sciencesen
cg.coverage.countryZambia
cg.coverage.iso3166-alpha2ZM
cg.coverage.regionAfrica
cg.coverage.regionSouthern Africa
cg.creator.identifierSara Lysholm: 0000-0002-0392-1572en
cg.creator.identifierJohanna Lindahl: 0000-0002-1175-0398en
cg.howPublishedFormally Publisheden
cg.identifier.doihttps://doi.org/10.1186/s12917-025-04732-wen
cg.isijournalISI Journalen
cg.issn1746-6148en
cg.journalBMC Veterinary Researchen
cg.reviewStatusPeer Reviewen
cg.subject.ilriANIMAL DISEASESen
cg.subject.ilriGOATSen
cg.subject.ilriPPRen
cg.subject.ilriSHEEPen
cg.subject.ilriSMALL RUMINANTSen
cg.subject.impactAreaNutrition, health and food security
cg.subject.sdgSDG 2 - Zero hungeren
cg.volume21en
dc.contributor.authorLysholm, Saraen
dc.contributor.authorLogan, N.en
dc.contributor.authorLindahl, Johanna F.en
dc.contributor.authorBerg, M.en
dc.contributor.authorJohansson, E.en
dc.contributor.authorBergkvist, P.K.en
dc.contributor.authorDautu, G.en
dc.contributor.authorChazya, R.en
dc.contributor.authorWillett, B.J.en
dc.contributor.authorMunyeme, M.en
dc.contributor.authorWensman, J.J.en
dc.date.accessioned2025-05-02T06:34:03Zen
dc.date.available2025-05-02T06:34:03Zen
dc.identifier.urihttps://hdl.handle.net/10568/174409
dc.titleDetection of canine distemper virus (CDV) neutralising antibodies in small ruminants during peste-des-petits-ruminants virus (PPRV) surveillance in Zambiaen
dcterms.abstractCanine distemper virus (CDV) is endemic in Zambia, while peste-des-petits-ruminants virus (PPRV) has not been detected. This study screened 962 farmed goats and 237 small ruminants at informal markets for PPRV antibodies using c-ELISA. A subset (n = 29) was re-analysed with virus neutralisation assays (VNA) for antibodies to PPRV and CDV due to cross-reactivity concerns. c-ELISA indicated 6.44% PPRV seroprevalence on farms and 3.80% at markets. While VNA detected no PPRV antibodies, 45% (13/29) tested positive for CDV, possibly suggesting cross-reactivity. Given the study’s limitations, further research is needed to determine whether PPRV is present in Zambia and assess potential cross-reactivity.en
dcterms.accessRightsOpen Access
dcterms.audienceAcademicsen
dcterms.audienceScientistsen
dcterms.available2025-04-30en
dcterms.bibliographicCitationLysholm, S., Logan, N., Lindahl, J.F., Berg, M., Johansson, E., Bergkvist, P.K., Dautu, G., Chazya, R., Willett, B.J., Munyeme, M. and Wensman, J.J. 2025. Detection of canine distemper virus (CDV) neutralising antibodies in small ruminants during peste-des-petits-ruminants virus (PPRV) surveillance in Zambia. BMC Veterinary Research 21: 303.en
dcterms.extent303en
dcterms.issued2025-04-30en
dcterms.languageen
dcterms.licenseCC-BY-4.0
dcterms.publisherBioMed Centralen
dcterms.subjectanimal diseasesen
dcterms.subjectcanine distemperen
dcterms.subjectgoatsen
dcterms.subjectpeste des petits ruminantsen
dcterms.subjectsheepen
dcterms.subjectsmall ruminantsen
dcterms.typeJournal Article

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