Two Theileria parva CD8 T Cell Antigen genes are more variable in buffalo than cattle parasites, but differ in pattern of sequence diversity

Simple item page
cg.creator.identifierRoger Pelle: 0000-0003-1053-085X
cg.creator.identifierPhilip Toye: 0000-0002-7100-2789
cg.creator.identifierRichard Bishop: 0000-0002-3720-9970
cg.creator.identifierDavid Odongo: 0000-0001-5745-4327
cg.identifier.doihttps://doi.org/10.1371/journal.pone.0019015en
cg.issn1932-6203en
cg.issue4en
cg.journalPLOS ONEen
cg.subject.ilriANIMAL DISEASESen
cg.subject.ilriCATTLEen
cg.subject.ilriDISEASE CONTROLen
cg.subject.ilriGENETICSen
cg.subject.ilriLIVESTOCKen
cg.subject.ilriVACCINESen
cg.volume6en
dc.contributor.authorPelle, Rogeren
dc.contributor.authorGraham, S.P.en
dc.contributor.authorNjahira, Moses N.en
dc.contributor.authorOsaso, J.en
dc.contributor.authorSaya, Rosemary M.en
dc.contributor.authorOdongo, David O.en
dc.contributor.authorToye, Philip G.en
dc.contributor.authorSpooner, P.R.en
dc.contributor.authorMusoke, A.J.en
dc.contributor.authorMwangi, David Mianoen
dc.contributor.authorTaracha, E.L.N.en
dc.contributor.authorMorrison, W. Ivanen
dc.contributor.authorWeir, W.en
dc.contributor.authorSilva, J.en
dc.contributor.authorBishop, Richard P.en
dc.date.accessioned2011-05-30T06:53:39Zen
dc.date.available2011-05-30T06:53:39Zen
dc.identifier.urihttps://hdl.handle.net/10568/3780
dc.titleTwo Theileria parva CD8 T Cell Antigen genes are more variable in buffalo than cattle parasites, but differ in pattern of sequence diversityen
dcterms.abstractTheileria parva causes an acute fatal disease in cattle, but infections are asymptomatic in the African buffalo (Syncerus caffer). Cattle can be immunized against the parasite by infection and treatment, but immunity is partially strain specific. Available data indicate that CD8+ T lymphocyte responses mediate protection and, recently, several parasite antigens recognised by CD8+ T cells have been identified. This study set out to determine the nature and extent of polymorphism in two of these antigens, Tp1 and Tp2, which contain defined CD8+ T-cell epitopes, and to analyse the sequences for evidence of selection.en
dcterms.accessRightsOpen Access
dcterms.available2011-04-29
dcterms.bibliographicCitationPelle, R., Graham, S.P., Njahira, M.N., Osaso, J., Saya, R.M., Odongo, D.O., Toye, P.G., Spooner, P.R., Musoke, A.J., Mwangi, D.M., Taracha, E.L.N., Morrison, W. Ivan, Weir, W., Silva, J.C., Bishop, R.P. 2011. Two Theileria parva CD8 T Cell Antigen genes are more variable in buffalo than cattle parasites, but differ in pattern of sequence diversity. PLoS ONE 6(4):e19015.en
dcterms.issued2011-04-29
dcterms.languageen
dcterms.licenseCC-BY-4.0
dcterms.publisherPublic Library of Scienceen
dcterms.subjectanimal diseasesen
dcterms.subjectcattleen
dcterms.typeJournal Article

Files

License bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.69 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

ILRI articles in journals