Genomic footprints of dryland stress adaptation in Egyptian fat-tail sheep and their divergence from East African and western Asia cohorts

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cg.authorship.typesCGIAR and developing country instituteen
cg.authorship.typesCGIAR and advanced research instituteen
cg.contributor.affiliationInternational Center for Agricultural Research in the Dry Areasen
cg.contributor.affiliationIowa State Universityen
cg.contributor.affiliationMinistry of Agriculture, Egypten
cg.contributor.crpLivestock
cg.coverage.countryEgypt
cg.coverage.iso3166-alpha2EG
cg.coverage.regionAfrica
cg.coverage.regionNorthern Africa
cg.creator.identifierJoram Mwacharo: 0000-0001-6981-8140
cg.creator.identifierBarbara Rischkowsky: 0000-0002-0035-471X
cg.howPublishedFormally Publisheden
cg.identifier.doihttps://doi.org/10.1038/s41598-017-17775-3en
cg.isijournalISI Journalen
cg.issn2045-2322en
cg.issue1en
cg.journalScientific Reportsen
cg.reviewStatusPeer Reviewen
cg.subject.ilriANIMAL BREEDINGen
cg.subject.ilriGENETICSen
cg.subject.ilriDRYLANDSen
cg.subject.ilriSHEEPen
cg.subject.ilriSMALL RUMINANTSen
cg.volume7en
dc.contributor.authorMwacharo, Joram M.en
dc.contributor.authorEui-Soo Kimen
dc.contributor.authorElbeltagy, Ahmed R.A.E.en
dc.contributor.authorAboul-Naga, A.M.en
dc.contributor.authorRischkowsky, Barbara A.en
dc.contributor.authorRothschild, Max F.en
dc.date.accessioned2018-12-08T13:09:30Zen
dc.date.available2018-12-08T13:09:30Zen
dc.identifier.urihttps://hdl.handle.net/10568/98489
dc.titleGenomic footprints of dryland stress adaptation in Egyptian fat-tail sheep and their divergence from East African and western Asia cohortsen
dcterms.abstractAfrican indigenous sheep are classified as fat-tail, thin-tail and fat-rump hair sheep. The fat-tail are well adapted to dryland environments, but little is known on their genome profiles. We analyzed patterns of genomic variation by genotyping, with the Ovine SNP50K microarray, 394 individuals from five populations of fat-tail sheep from a desert environment in Egypt. Comparative inferences with other East African and western Asia fat-tail and European sheep, reveal at least two phylogeographically distinct genepools of fat-tail sheep in Africa that differ from the European genepool, suggesting separate evolutionary and breeding history. We identified 24 candidate selection sweep regions, spanning 172 potentially novel and known genes, which are enriched with genes underpinning dryland adaptation physiology. In particular, we found selection sweeps spanning genes and/or pathways associated with metabolism; response to stress, ultraviolet radiation, oxidative stress and DNA damage repair; activation of immune response; regulation of reproduction, organ function and development, body size and morphology, skin and hair pigmentation, and keratinization. Our findings provide insights on the complexity of genome architecture regarding dryland stress adaptation in the fat-tail sheep and showcase the indigenous stocks as appropriate genotypes for adaptation planning to sustain livestock production and human livelihoods, under future climates.en
dcterms.accessRightsOpen Access
dcterms.audienceScientistsen
dcterms.available2017-12-15
dcterms.bibliographicCitationMwacharo, J.M., Kim, E., Elbeltagy, A.R., Aboul-Naga, A.M., Rischkowsky, B.A. and Rothschild, M.F. 2017. Genomic footprints of dryland stress adaptation in Egyptian fat-tail sheep and their divergence from East African and western Asia cohorts. Scientific Reports 7:17647.en
dcterms.issued2017
dcterms.languageen
dcterms.licenseCC-BY-4.0
dcterms.publisherSpringeren
dcterms.subjectanimal breedingen
dcterms.subjectgeneticsen
dcterms.subjectdrylandsen
dcterms.subjectsheepen
dcterms.subjectsmall ruminantsen
dcterms.typeJournal Article

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