Persistence of the efficacy of copper oxide wire particles against Haemonchus contortus in grazing South African goats

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cg.coverage.countrySouth Africaen_US
cg.coverage.iso3166-alpha2ZAen_US
cg.coverage.regionAfricaen_US
cg.coverage.regionSouthern Africaen_US
cg.identifier.doihttps://doi.org/10.1016/j.vetpar.2012.06.018en_US
cg.issn0304-4017en_US
cg.issue1-2en_US
cg.journalVeterinary Parasitologyen_US
cg.subject.ilriANIMAL DISEASESen_US
cg.subject.ilriANIMAL HEALTHen_US
cg.subject.ilriDISEASE CONTROLen_US
cg.subject.ilriGOATSen_US
cg.subject.ilriLIVESTOCKen_US
cg.volume190en_US
dc.contributor.authorVatta, A.F.en_US
dc.contributor.authorWaller, P.J.en_US
dc.contributor.authorGithiori, J.B.en_US
dc.contributor.authorMedley, G.F.en_US
dc.date.accessioned2012-06-26T08:02:55Zen_US
dc.date.available2012-06-26T08:02:55Zen_US
dc.identifier.urihttps://hdl.handle.net/10568/21124en_US
dc.titlePersistence of the efficacy of copper oxide wire particles against Haemonchus contortus in grazing South African goatsen_US
dcterms.abstractA study was conducted to examine the duration of anthelmintic effect of copper oxide wire particles (COWP) in grazing goats, as data for the persistence of efficacy of COWP in this host species is limited. Forty-eight indigenous male goats were infected naturally by grazing them on Haemonchus contortus-infected pasture. When the faecal egg count (FEC) in the goats was 3 179 ± 540 eggs per gram of faeces (mean ± standard error), half the animals were treated with 4 g COWP (day 0; mean live weight = 25.5 ± 0.8 kg). Eight treated (COWP) and eight non-treated (CONTROL) goats were removed from the pasture on each of days 7, 28 and 56, maintained for 27 or 29 days in concrete pens and then humanely slaughtered for nematode recovery. Mean liver copper levels were in the high range in the goats removed from pasture at day 7 (treated: 191 ± 19.7 ppm; untreated: 120 ± 19.7 ppm; P = 0.022), but had dropped to normal levels at days 28 and 56. The mean H. contortus burdens of the treated versus the non-treated goats were, respectively, 184 ± 48 and 645 ± 152 for the goats removed from pasture at day 7 (71% reduction; P = 0.004), 207 ± 42 and 331 ± 156 at day 28 (37% reduction; P = 0.945) and 336 ± 89 and 225 ± 53 at day 56 (-49% reduction; P = 0.665). Weekly monitoring of FECs after treatment until slaughter indicated that the COWP-treated goats had lower FECs than the controls, the treatment main effect being significant at days 7, 28 and 56 (P < 0.01). The day main effect and the treatment x day interaction were only significant for the goats removed from pasture at day 28 (P ≤ 0.001). Packed cell volumes increased during the course of the experiment (day, P < 0.001), but the treatment main effect was significant only for the goats removed from pasture at day 28 (CONTROL 28 d, 28.65 ± 0.52% < COWP 28 d, 31.31 ± 0.52%; P < 0.001). No differences in live weight between groups were considered to be of any practical significance. The study indicated that persistence of efficacy of COWP is limited in goats, extending at most to 28 days after treatment. However, repeated COWP administration at three-month intervals may be safe, given that liver copper levels return to normal two to three months after COWP treatment.en_US
dcterms.accessRightsOpen Accessen_US
dcterms.bibliographicCitationVatta, A.F., Waller, P.J., Githiori, J.B. and Medley, G.F. 2012. Persistence of the efficacy of copper oxide wire particles against Haemonchus contortus in grazing South African goats. Veterinary Parasitology 190(1-2):159-166.en_US
dcterms.extentp. 159-166en_US
dcterms.issued2012-11en_US
dcterms.languageenen_US
dcterms.licenseCC-BY-3.0en_US
dcterms.publisherElsevieren_US
dcterms.subjectgoatsen_US
dcterms.subjectanimal healthen_US
dcterms.typeJournal Articleen_US

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