Multiple genomic signatures of selection in goats and sheep indigenous to a hot arid environment

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cg.authorship.typesCGIAR and developing country instituteen
cg.authorship.typesCGIAR and advanced research instituteen
cg.contributor.affiliationIowa State Universityen
cg.contributor.affiliationMinistry of Agriculture, Egypten
cg.contributor.affiliationInternational Center for Agricultural Research in the Dry Areasen
cg.contributor.affiliationVirginia Polytechnic Institute and State Universityen
cg.contributor.crpLivestock and Fish
cg.creator.identifierBarbara Rischkowsky: 0000-0002-0035-471Xen
cg.creator.identifierJoram Mwacharo: 0000-0001-6981-8140en
cg.howPublishedFormally Publisheden
cg.identifier.doihttps://doi.org/10.1038/hdy.2015.94en
cg.isijournalISI Journalen
cg.issn1365-2540en
cg.issue3en
cg.journalHeredityen
cg.reviewStatusPeer Reviewen
cg.subject.icardaBIODIVERSITY AND INTEGRATED GENE MANAGEMENTen
cg.volume116en
dc.contributor.authorKim, E.S.en
dc.contributor.authorElbeltagy, A.R.en
dc.contributor.authorAboul-Naga, A.M.en
dc.contributor.authorRischkowsky, Barbara A.en
dc.contributor.authorSayre, B.en
dc.contributor.authorMwacharo, Joram M.en
dc.contributor.authorRothschild, Max F.en
dc.date.accessioned2016-03-09T13:17:16Zen
dc.date.available2016-03-09T13:17:16Zen
dc.identifier.urihttps://hdl.handle.net/10568/72521
dc.titleMultiple genomic signatures of selection in goats and sheep indigenous to a hot arid environmenten
dcterms.abstractGoats and sheep are versatile domesticates that have been integrated into diverse environments and production systems. Natural and artificial selection have shaped the variation in the two species, but natural selection has played the major role among indigenous flocks. To investigate signals of natural selection, we analyzed genotype data generated using the caprine and ovine 50K SNP BeadChips from Barki goats and sheep that are indigenous to a hot arid environment in Egypt|[rsquo]|s Coastal Zone of the Western Desert. We identify several candidate regions under selection that spanned 119 genes. A majority of the genes were involved in multiple signaling and signal transduction pathways in a wide variety of cellular and biochemical processes. In particular, selection signatures spanning several genes that directly or indirectly influenced traits for adaptation to hot arid environments, such as thermo-tolerance (melanogenesis) (FGF2, GNAI3, PLCB1), body size and development (BMP2, BMP4, GJA3, GJB2), energy and digestive metabolism (MYH, TRHDE, ALDH1A3), and nervous and autoimmune response (GRIA1, IL2, IL7, IL21, IL1R1) were identified. We also identified eight common candidate genes under selection in the two species and a shared selection signature that spanned a conserved syntenic segment to bovine chromosome 12 on caprine and ovine chromosomes 12 and 10, respectively, providing, most likely, the evidence for selection in a common environment in two different but closely related species. Our study highlights the importance of indigenous livestock as model organisms for investigating selection sweeps and genome-wide association mapping.en
dcterms.accessRightsOpen Access
dcterms.audienceScientistsen
dcterms.available2015-11-11en
dcterms.bibliographicCitationKim, E-S., Elbeltagy, A.R., Aboul-Naga, A.M., Rischkowsky, B., Sayre, B., Mwacharo, J.M. and Rothschild, M.F. 2016. Multiple genomic signatures of selection in goats and sheep indigenous to a hot arid environment. Heredity 116(3): 255-264en
dcterms.extentpp. 255-264en
dcterms.issued2016-03en
dcterms.languageen
dcterms.licenseCopyrighted; all rights reserved
dcterms.publisherSpringeren
dcterms.subjectsheepen
dcterms.subjectgoatsen
dcterms.subjectindigenous breedsen
dcterms.subjectenvironmenten
dcterms.subjectresearchen
dcterms.typeJournal Article

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