Multiple genomic signatures of selection in goats and sheep indigenous to a hot arid environment

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cg.authorship.typesCGIAR and developing country instituteen_US
cg.authorship.typesCGIAR and advanced research instituteen_US
cg.contributor.affiliationIowa State Universityen_US
cg.contributor.affiliationMinistry of Agriculture, Egypten_US
cg.contributor.affiliationInternational Center for Agricultural Research in the Dry Areasen_US
cg.contributor.affiliationVirginia Polytechnic Institute and State Universityen_US
cg.contributor.crpLivestock and Fishen_US
cg.creator.identifierBarbara Rischkowsky: 0000-0002-0035-471Xen_US
cg.creator.identifierJoram Mwacharo: 0000-0001-6981-8140en_US
cg.howPublishedFormally Publisheden_US
cg.identifier.doihttps://doi.org/10.1038/hdy.2015.94en_US
cg.isijournalISI Journalen_US
cg.issn1365-2540en_US
cg.issue3en_US
cg.journalHeredityen_US
cg.reviewStatusPeer Reviewen_US
cg.subject.icardaBIODIVERSITY AND INTEGRATED GENE MANAGEMENTen_US
cg.volume116en_US
dc.contributor.authorKim, E.S.en_US
dc.contributor.authorElbeltagy, A.R.en_US
dc.contributor.authorAboul-Naga, A.M.en_US
dc.contributor.authorRischkowsky, Barbara A.en_US
dc.contributor.authorSayre, B.en_US
dc.contributor.authorMwacharo, Joram M.en_US
dc.contributor.authorRothschild, Max F.en_US
dc.date.accessioned2016-03-09T13:17:16Zen_US
dc.date.available2016-03-09T13:17:16Zen_US
dc.identifier.urihttps://hdl.handle.net/10568/72521en_US
dc.titleMultiple genomic signatures of selection in goats and sheep indigenous to a hot arid environmenten_US
dcterms.abstractGoats and sheep are versatile domesticates that have been integrated into diverse environments and production systems. Natural and artificial selection have shaped the variation in the two species, but natural selection has played the major role among indigenous flocks. To investigate signals of natural selection, we analyzed genotype data generated using the caprine and ovine 50K SNP BeadChips from Barki goats and sheep that are indigenous to a hot arid environment in Egypt|[rsquo]|s Coastal Zone of the Western Desert. We identify several candidate regions under selection that spanned 119 genes. A majority of the genes were involved in multiple signaling and signal transduction pathways in a wide variety of cellular and biochemical processes. In particular, selection signatures spanning several genes that directly or indirectly influenced traits for adaptation to hot arid environments, such as thermo-tolerance (melanogenesis) (FGF2, GNAI3, PLCB1), body size and development (BMP2, BMP4, GJA3, GJB2), energy and digestive metabolism (MYH, TRHDE, ALDH1A3), and nervous and autoimmune response (GRIA1, IL2, IL7, IL21, IL1R1) were identified. We also identified eight common candidate genes under selection in the two species and a shared selection signature that spanned a conserved syntenic segment to bovine chromosome 12 on caprine and ovine chromosomes 12 and 10, respectively, providing, most likely, the evidence for selection in a common environment in two different but closely related species. Our study highlights the importance of indigenous livestock as model organisms for investigating selection sweeps and genome-wide association mapping.en_US
dcterms.accessRightsOpen Accessen_US
dcterms.audienceScientistsen_US
dcterms.available2015-11-11en_US
dcterms.bibliographicCitationKim, E-S., Elbeltagy, A.R., Aboul-Naga, A.M., Rischkowsky, B., Sayre, B., Mwacharo, J.M. and Rothschild, M.F. 2016. Multiple genomic signatures of selection in goats and sheep indigenous to a hot arid environment. Heredity 116(3): 255-264en_US
dcterms.extentpp. 255-264en_US
dcterms.issued2016-03en_US
dcterms.languageenen_US
dcterms.licenseCopyrighted; all rights reserveden_US
dcterms.publisherSpringeren_US
dcterms.subjectsheepen_US
dcterms.subjectgoatsen_US
dcterms.subjectindigenous breedsen_US
dcterms.subjectenvironmenten_US
dcterms.subjectresearchen_US
dcterms.typeJournal Articleen_US

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