Selective constraints in cold‐region wild boars may defuse the effects of small effective population size on molecular evolution of mitogenomes

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cg.authorship.typesCGIAR and developing country instituteen
cg.authorship.typesCGIAR and advanced research instituteen
cg.contributor.affiliationHuazhong Agricultural Universityen
cg.contributor.affiliationUniversity of Chicagoen
cg.contributor.affiliationNational Institute of Animal Sciences, Vietnamen
cg.contributor.affiliationNovosibirsk State Agrarian Universityen
cg.contributor.affiliationInternational Livestock Research Instituteen
cg.contributor.affiliationUniversity of Zagreben
cg.contributor.crpLivestock
cg.contributor.donorNational Natural Science Foundation of Chinaen
cg.contributor.donorNational High Technology Research and Development Program, Chinaen
cg.howPublishedFormally Publisheden
cg.identifier.doihttps://doi.org/10.1002/ece3.4221en
cg.isijournalISI Journalen
cg.issn2045-7758en
cg.issue16en
cg.journalEcology and Evolutionen
cg.reviewStatusPeer Reviewen
cg.subject.ilriRESEARCHen
cg.volume8en
dc.contributor.authorJianhai Chenen
dc.contributor.authorPan Nien
dc.contributor.authorThuy Nhien Tran Thien
dc.contributor.authorKamaldinov, E.V.en
dc.contributor.authorPetukhovm V.L.en
dc.contributor.authorHan Jianlinen
dc.contributor.authorXiangdong Liuen
dc.contributor.authorŠprem, N.en
dc.contributor.authorShuhong Zhaoen
dc.date.accessioned2018-08-15T14:50:23Zen
dc.date.available2018-08-15T14:50:23Zen
dc.identifier.urihttps://hdl.handle.net/10568/96568
dc.titleSelective constraints in cold‐region wild boars may defuse the effects of small effective population size on molecular evolution of mitogenomesen
dcterms.abstractSpatial range expansion during population colonization is characterized by demographic events that may have significant effects on the efficiency of natural selection. Population genetics suggests that genetic drift brought by small effective population size (Ne) may undermine the efficiency of selection, leading to a faster accumulation of nonsynonymous mutations. However, it is still unknown whether this effect might be balanced or even reversed by strong selective constraints. Here, we used wild boars and local domestic pigs from tropical (Vietnam) and subarctic region (Siberia) as animal model to evaluate the effects of functional constraints and genetic drift on shaping molecular evolution. The likelihood‐ratio test revealed that Siberian clade evolved significantly different from Vietnamese clades. Different datasets consistently showed that Siberian wild boars had lower Ka/Ks ratios than Vietnamese samples. The potential role of positive selection for branches with higher Ka/Ks was evaluated using branch‐site model comparison. No signal of positive selection was found for the higher Ka/Ks in Vietnamese clades, suggesting the interclade difference was mainly due to the reduction in Ka/Ks for Siberian samples. This conclusion was further confirmed by the result from a larger sample size, among which wild boars from northern Asia (subarctic and nearby region) had lower Ka/Ks than those from southern Asia (temperate and tropical region). The lower Ka/Ks might be due to either stronger functional constraints, which prevent nonsynonymous mutations from accumulating in subarctic wild boars, or larger Ne in Siberian wild boars, which can boost the efficacy of purifying selection to remove functional mutations. The latter possibility was further ruled out by the Bayesian skyline plot analysis, which revealed that historical Ne of Siberian wild boars was smaller than that of Vietnamese wild boars. Altogether, these results suggest stronger functional constraints acting on mitogenomes of subarctic wild boars, which may provide new insights into their local adaptation of cold resistance.en
dcterms.accessRightsOpen Access
dcterms.audienceScientistsen
dcterms.available2018-07-21
dcterms.bibliographicCitationJianhai Chen, Pan Ni, Thuy Nhien Tran Thi, Kamaldinov, E.V., Petukhovm V.L., Jianlin Han, Xiangdong Liu, Šprem, N. and Shuhong Zhao. 2018. Selective constraints in cold‐region wild boars may defuse the effects of small effective population size on molecular evolution of mitogenomes. Ecology and Evolution 8:8102–8114.en
dcterms.extentp. 8102-8114en
dcterms.issued2018-08
dcterms.languageen
dcterms.licenseCC-BY-4.0
dcterms.publisherWileyen
dcterms.subjectresearchen
dcterms.subjectpopulationen
dcterms.typeJournal Article

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