Genetic estimates and genome-wide association studies of antibody response in Tanzanian dairy cattle

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cg.authorship.typesCGIAR and developing country instituteen
cg.authorship.typesCGIAR and advanced research instituteen
cg.contributor.affiliationUniversity of Edinburghen
cg.contributor.affiliationInternational Livestock Research Instituteen
cg.contributor.affiliationNelson Mandela African Institution of Science and Technologyen
cg.contributor.affiliationTanzania Veterinary Laboratory Agencyen
cg.contributor.affiliationScotland’s Rural Collegeen
cg.contributor.affiliationTanzania Livestock Research Instituteen
cg.contributor.donorGates Foundationen
cg.contributor.donorForeign, Commonwealth and Development Office, United Kingdomen
cg.coverage.countryTanzaniaen
cg.coverage.iso3166-alpha2TZen
cg.coverage.regionAfricaen
cg.coverage.regionEastern Africaen
cg.coverage.regionSouthern Africaen
cg.creator.identifierElizabeth Cook: 0000-0001-6081-8363en
cg.creator.identifierRaphael Mrode: 0000-0003-1964-5653en
cg.creator.identifierBenedict E. Karani: 0009-0004-6233-875Xen
cg.creator.identifierAlly Okeyo Mwai: 0000-0003-2379-7801en
cg.creator.identifierJames Prendergast: 0000-0001-8916-018Xen
cg.creator.identifierPhilip Toye: 0000-0002-7100-2789en
cg.creator.identifierDaniel Komwihangilo: 0000-0002-3291-9869en
cg.creator.identifierGabriel Shirima: 0000-0001-7768-711Xen
cg.creator.identifierMark Bronsvoort: 0000-0002-3271-8485en
cg.howPublishedFormally Publisheden
cg.identifier.dataurlhttps://datashare.ed.ac.uk/handle/10283/8974en
cg.identifier.doihttps://doi.org/10.3389/fgene.2025.1497355en
cg.isijournalISI Journalen
cg.issn1664-8021en
cg.journalFrontiers in Geneticsen
cg.subject.ilriCATTLEen
cg.subject.ilriDAIRYINGen
cg.subject.ilriGENETICSen
cg.subject.impactAreaNutrition, health and food securityen
cg.subject.sdgSDG 2 - Zero hungeren
cg.volume16en
dc.contributor.authorHernandez-Castro, L.E.en
dc.contributor.authorCook, Elizabeth A.J.en
dc.contributor.authorMatika, O.en
dc.contributor.authorMengele, I.J.en
dc.contributor.authorMotto, S.K.en
dc.contributor.authorBwatota, S.F.en
dc.contributor.authorZirra-Shallangwa, B.en
dc.contributor.authorPong-Wong, R.en
dc.contributor.authorPrendergast, J.en
dc.contributor.authorMrode, Raphael A.en
dc.contributor.authorToye, Philip G.en
dc.contributor.authorKomwihangilo, D.M.en
dc.contributor.authorLyatuu, E.en
dc.contributor.authorKarani, Benedict E.en
dc.contributor.authorNangekhe, Gertrudeen
dc.contributor.authorOkeyo Mwai, Allyen
dc.contributor.authorShirima, G.M.en
dc.contributor.authorBronsvoort, B.M. de C.en
dc.date.accessioned2025-04-28T05:42:27Zen
dc.date.available2025-04-28T05:42:27Zen
dc.identifier.urihttps://hdl.handle.net/10568/174340
dc.titleGenetic estimates and genome-wide association studies of antibody response in Tanzanian dairy cattleen
dcterms.abstractIdentifying the genetic determinants of host defence against infectious pathogens is central to enhancing disease resilience and therapeutic efficacy in livestock. Here, we investigated immune response heritability to important infectious diseases affecting smallholder dairy cattle using variance component analysis. We also conducted genome-wide association studies (GWAS) to identify genetic variants that may help understand the underlying biology of these health traits. By assessing 668,911 single-nucleotide polymorphisms (SNPs) genotyped in 2,045 crossbred cattle sampled from six regions of Tanzania, we identified high levels of interregional admixture and European introgression, which may increase infectious disease susceptibility relative to indigenous breeds. Heritability estimates were low to moderate, ranging from 0.03 (SE ± 0.06) to 0.44 (SE ± 0.07), depending on the health trait. GWAS results revealed several loci associated with seropositivity to the viral diseases Rift Valley fever and bovine viral diarrhoea, the protozoan parasites <i>Neospora caninum</i> and <i>Toxoplasma gondii</i>, and the bacterial pathogens <i>Brucella</i> sp., <i>Leptospira</i> hardjo, and <i>Coxiella burnetii</i>. The identified quantitative trait loci mapped to genes involved in immune defence, tumour suppression, neurological processes, and cell exocytosis. We propose that our results provide a basis for future understanding of the cellular pathways contributing to general and taxon-specific infection responses, and for advancing selective breeding and therapeutic target design.en
dcterms.accessRightsOpen Accessen
dcterms.audienceAcademicsen
dcterms.audienceScientistsen
dcterms.available2025-04-24en
dcterms.bibliographicCitationHernandez-Castro, L.E., Cook, E.A.J., Matika, O., Mengele, I.J., Motto, S.K., Bwatota, S.F., Zirra-Shallangwa, B., Pong-Wong, R., Prendergast, J., Mrode, R., Toye, P.G., Komwihangilo, D.M., Lyatuu, E., Karani, B.E., Nangekhe, G., Mwai, A.O., Shirima, G.M. and Bronsvoort, B.M. de C. 2025. Genetic estimates and genome-wide association studies of antibody response in Tanzanian dairy cattle. Frontiers in Genetics 16: 1497355.en
dcterms.extent1497355en
dcterms.issued2025-04-24en
dcterms.languageenen
dcterms.licenseCC-BY-4.0en
dcterms.publisherFrontiers Mediaen
dcterms.subjectcattleen
dcterms.subjectdairyingen
dcterms.subjectgeneticsen
dcterms.subjectgenomicsen
dcterms.typeJournal Articleen

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