Genome-wide comparative analyses reveal selection signatures underlying adaptation and production in Tibetan and Poll Dorset sheep

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cg.authorship.typesCGIAR and developing country instituteen
cg.contributor.affiliationChinese Academy of Agricultural Sciencesen
cg.contributor.affiliationInternational Livestock Research Instituteen
cg.contributor.affiliationGansu Agricultural Universityen
cg.contributor.affiliationQinghai Academy of Animal Science and Veterinary Medicineen
cg.contributor.affiliationAnimal Husbandry and Veterinary Service of Qinghai, Chinaen
cg.contributor.affiliationInternational Center for Agricultural Research in the Dry Areasen
cg.contributor.crpLivestock
cg.creator.identifierJoram Mwacharo: 0000-0001-6981-8140
cg.howPublishedFormally Publisheden
cg.identifier.doihttps://doi.org/10.1038/s41598-021-81932-yen
cg.isijournalISI Journalen
cg.issn2045-2322en
cg.issue1en
cg.journalScientific Reportsen
cg.reviewStatusPeer Reviewen
cg.subject.ilriANIMAL BREEDINGen
cg.subject.ilriBREEDSen
cg.subject.ilriGENETICSen
cg.subject.ilriINDIGENOUS BREEDSen
cg.subject.ilriSHEEPen
cg.subject.ilriSMALL RUMINANTSen
cg.volume11en
dc.contributor.authorYingyue Zhangen
dc.contributor.authorXianglan Xueen
dc.contributor.authorYue Liuen
dc.contributor.authorAbied, A.en
dc.contributor.authorYangyang Dingen
dc.contributor.authorShengguo Zhaoen
dc.contributor.authorWenqiang Wangen
dc.contributor.authorLiqing Maen
dc.contributor.authorJijun Guoen
dc.contributor.authorWeijun Guanen
dc.contributor.authorYabin Puen
dc.contributor.authorMwacharo, Joram M.en
dc.contributor.authorHan Jianlinen
dc.contributor.authorYuehui Maen
dc.contributor.authorQianjun Zhaoen
dc.date.accessioned2021-07-26T08:12:56Zen
dc.date.available2021-07-26T08:12:56Zen
dc.identifier.urihttps://hdl.handle.net/10568/114369
dc.titleGenome-wide comparative analyses reveal selection signatures underlying adaptation and production in Tibetan and Poll Dorset sheepen
dcterms.abstractThe identification of genome-wide selection signatures can provide insights on the mechanisms of natural and/or artificial selection and uncover genes related to biological functions and/or phenotypes. Tibetan sheep are an important livestock in Tibet, providing meat and wool for Tibetans who are renown for breeding livestock that adapt well to high altitudes. Using whole-genome sequences with an effective sequencing depth of 5×, we investigated the genomic diversity and structure and, identified selection signatures of White Tibetan, Oula and Poll Dorset sheep. We obtained 30,163,679 Single Nucleotide Polymorphisms (SNPs) and 5,388,372 indels benchmarked against the ovine Oar_v4.0 genome assembly. Next, using FST, ZHp and XP-EHH approaches, we identified selection signatures spanning a set of candidate genes, including HIF1A, CAPN3, PRKAA1, RXFP2, TRHR and HOXA10 that are associated with pathways and GO categories putatively related to hypoxia responses, meat traits and disease resistance. Candidate genes and GO terms associated with coat color were also identified. Finally, quantification of blood physiological parameters, revealed higher levels of mean corpuscular hemoglobin measurement and mean corpuscular hemoglobin concentration in Tibetan sheep compared with Poll Dorset, suggesting a greater oxygen-carrying capacity in the Tibetan sheep and thus better adaptation to high-altitude hypoxia. In conclusion, this study provides a greater understanding of genome diversity and variations associated with adaptive and production traits in sheep.en
dcterms.accessRightsOpen Access
dcterms.audienceScientistsen
dcterms.available2021-01-28
dcterms.bibliographicCitationYingyue Zhang, Xianglan Xue, Yue Liu, Abied, A., Yangyang Ding, Shengguo Zhao, Wenqiang Wang, Liqing Ma, Jijun Guo, Weijun Guan, Yabin Pu, Mwacharo, J.M., Jianlin Han, Yuehui Ma and Qianjun Zhao. 2021. Genome-wide comparative analyses reveal selection signatures underlying adaptation and production in Tibetan and Poll Dorset sheep. Scientific Reports 11: 2466.en
dcterms.issued2021-01-28
dcterms.languageen
dcterms.licenseCC-BY-4.0
dcterms.publisherSpringeren
dcterms.subjectanimal breedingen
dcterms.subjectgeneticsen
dcterms.subjectsheepen
dcterms.subjectsmall ruminantsen
dcterms.subjectindigenous breedsen
dcterms.typeJournal Article

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