Approaches to vaccination against Theileria parva and Theileria annulata
| cg.authorship.types | CGIAR and advanced research institute | en |
| cg.contributor.affiliation | International Livestock Research Institute | en |
| cg.contributor.affiliation | University of Edinburgh | en |
| cg.contributor.crp | Livestock and Fish | |
| cg.contributor.donor | Department for International Development, United Kingdom | en |
| cg.contributor.donor | Biotechnology and Biological Sciences Research Council, United Kingdom | en |
| cg.contributor.donor | Bill & Melinda Gates Foundation | en |
| cg.contributor.donor | United States Agency for International Development | en |
| cg.creator.identifier | Vishvanath Nene: 0000-0001-7066-4169 | |
| cg.howPublished | Formally Published | en |
| cg.identifier.doi | https://doi.org/10.1111/pim.12388 | en |
| cg.isijournal | ISI Journal | en |
| cg.issn | 0141-9838 | en |
| cg.issue | 12 | en |
| cg.journal | Parasite Immunology | en |
| cg.reviewStatus | Peer Review | en |
| cg.species | Theileria parva | en |
| cg.subject.ilri | ANIMAL DISEASES | en |
| cg.subject.ilri | CATTLE | en |
| cg.subject.ilri | DISEASE CONTROL | en |
| cg.subject.ilri | ECF | en |
| cg.subject.ilri | LIVESTOCK | en |
| cg.subject.ilri | VACCINES | en |
| cg.volume | 38 | en |
| dc.contributor.author | Nene, Vishvanath M. | en |
| dc.contributor.author | Morrison, W. Ivan | en |
| dc.date.accessioned | 2017-02-23T09:29:31Z | en |
| dc.date.available | 2017-02-23T09:29:31Z | en |
| dc.identifier.uri | https://hdl.handle.net/10568/80004 | |
| dc.title | Approaches to vaccination against Theileria parva and Theileria annulata | en |
| dcterms.abstract | Despite having different cell tropism, the pathogenesis and immunobiology of the diseases caused by Theileria parva and Theileria annulata are remarkably similar. Live vaccines have been available for both parasites for over 40 years, but although they provide strong protection, practical disadvantages have limited their widespread application. Efforts to develop alternative vaccines using defined parasite antigens have focused on the sporozoite and intracellular schizont stages of the parasites. Experimental vaccination studies using viral vectors expressing T. parva schizont antigens and T. parva and T. annulata sporozoite antigens incorporated in adjuvant have, in each case, demonstrated protection against parasite challenge in a proportion of vaccinated animals. Current work is investigating alternative antigen delivery systems in an attempt to improve the levels of protection. The genome architecture and protein-coding capacity of T. parva and T. annulata are remarkably similar. The major sporozoite surface antigen in both species and most of the schizont antigens are encoded by orthologous genes. The former have been shown to induce species cross-reactive neutralizing antibodies, and comparison of the schizont antigen orthologues has demonstrated that some of them display high levels of sequence conservation. Hence, advances in development of subunit vaccines against one parasite species are likely to be readily applicable to the other. | en |
| dcterms.accessRights | Open Access | |
| dcterms.audience | Scientists | en |
| dcterms.available | 2016-12-21 | |
| dcterms.bibliographicCitation | Nene, V. and Morrison, W.I. 2016. Approaches to vaccination against Theileria parva and Theileria annulata. Parasite Immunology 38(12):724-734. | en |
| dcterms.extent | p. 724-734 | en |
| dcterms.issued | 2016-12 | |
| dcterms.language | en | |
| dcterms.license | CC-BY-4.0 | |
| dcterms.publisher | Wiley | en |
| dcterms.subject | theileria | en |
| dcterms.subject | cattle | en |
| dcterms.subject | animal diseases | en |
| dcterms.subject | vaccines | en |
| dcterms.subject | disease control | en |
| dcterms.subject | east coast fever | en |
| dcterms.type | Journal Article |
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