Approaches to vaccination against Theileria parva and Theileria annulata

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cg.authorship.typesCGIAR and advanced research instituteen_US
cg.contributor.affiliationInternational Livestock Research Instituteen_US
cg.contributor.affiliationUniversity of Edinburghen_US
cg.contributor.crpLivestock and Fishen_US
cg.contributor.donorDepartment for International Development, United Kingdomen_US
cg.contributor.donorBiotechnology and Biological Sciences Research Council, United Kingdomen_US
cg.contributor.donorBill & Melinda Gates Foundationen_US
cg.contributor.donorUnited States Agency for International Developmenten_US
cg.creator.identifierVishvanath Nene: 0000-0001-7066-4169en_US
cg.howPublishedFormally Publisheden_US
cg.identifier.doihttps://doi.org/10.1111/pim.12388en_US
cg.isijournalISI Journalen_US
cg.issn0141-9838en_US
cg.issue12en_US
cg.journalParasite Immunologyen_US
cg.reviewStatusPeer Reviewen_US
cg.speciesTheileria parvaen_US
cg.subject.ilriANIMAL DISEASESen_US
cg.subject.ilriCATTLEen_US
cg.subject.ilriDISEASE CONTROLen_US
cg.subject.ilriECFen_US
cg.subject.ilriLIVESTOCKen_US
cg.subject.ilriVACCINESen_US
cg.volume38en_US
dc.contributor.authorNene, Vishvanath M.en_US
dc.contributor.authorMorrison, W. Ivanen_US
dc.date.accessioned2017-02-23T09:29:31Zen_US
dc.date.available2017-02-23T09:29:31Zen_US
dc.identifier.urihttps://hdl.handle.net/10568/80004en_US
dc.titleApproaches to vaccination against Theileria parva and Theileria annulataen_US
dcterms.abstractDespite having different cell tropism, the pathogenesis and immunobiology of the diseases caused by Theileria parva and Theileria annulata are remarkably similar. Live vaccines have been available for both parasites for over 40 years, but although they provide strong protection, practical disadvantages have limited their widespread application. Efforts to develop alternative vaccines using defined parasite antigens have focused on the sporozoite and intracellular schizont stages of the parasites. Experimental vaccination studies using viral vectors expressing T. parva schizont antigens and T. parva and T. annulata sporozoite antigens incorporated in adjuvant have, in each case, demonstrated protection against parasite challenge in a proportion of vaccinated animals. Current work is investigating alternative antigen delivery systems in an attempt to improve the levels of protection. The genome architecture and protein-coding capacity of T. parva and T. annulata are remarkably similar. The major sporozoite surface antigen in both species and most of the schizont antigens are encoded by orthologous genes. The former have been shown to induce species cross-reactive neutralizing antibodies, and comparison of the schizont antigen orthologues has demonstrated that some of them display high levels of sequence conservation. Hence, advances in development of subunit vaccines against one parasite species are likely to be readily applicable to the other.en_US
dcterms.accessRightsOpen Accessen_US
dcterms.audienceScientistsen_US
dcterms.available2016-12-21en_US
dcterms.bibliographicCitationNene, V. and Morrison, W.I. 2016. Approaches to vaccination against Theileria parva and Theileria annulata. Parasite Immunology 38(12):724-734.en_US
dcterms.extentp. 724-734en_US
dcterms.issued2016-12en_US
dcterms.languageenen_US
dcterms.licenseCC-BY-4.0en_US
dcterms.publisherWileyen_US
dcterms.subjecttheileriaen_US
dcterms.subjectcattleen_US
dcterms.subjectanimal diseasesen_US
dcterms.subjectvaccinesen_US
dcterms.subjectdisease controlen_US
dcterms.subjecteast coast feveren_US
dcterms.typeJournal Articleen_US

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