Experimental evaluation of inactivated and live attenuated vaccines against Mycoplasma mycoides subsp. Mycoides

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cg.authorship.typesCGIAR and advanced research instituteen
cg.contributor.affiliationInternational Livestock Research Instituteen
cg.contributor.affiliationKenya Agricultural and Livestock Research Organizationen
cg.contributor.affiliationUniversity of Nairobien
cg.contributor.affiliationInternational Vaccine Centre, Canadaen
cg.contributor.crpLivestock and Fish
cg.coverage.regionAfrica
cg.creator.identifierJan Naessens: 0000-0002-7075-9915
cg.howPublishedFormally Publisheden
cg.identifier.doihttps://doi.org/10.1016/j.vetimm.2015.12.006en
cg.isijournalISI Journalen
cg.issn0165-2427en
cg.journalVeterinary Immunology and Immunopathologyen
cg.reviewStatusPeer Reviewen
cg.subject.ilriANIMAL DISEASESen
cg.subject.ilriCBPPen
cg.subject.ilriDISEASE CONTROLen
cg.subject.ilriLIVESTOCKen
cg.subject.ilriVACCINESen
cg.volume169en
dc.contributor.authorMwirigi, M.en
dc.contributor.authorNkando, I.en
dc.contributor.authorAye, R.en
dc.contributor.authorSoi, R.en
dc.contributor.authorOchanda, H.en
dc.contributor.authorBerberov, E.en
dc.contributor.authorPotter, A.en
dc.contributor.authorGerdts, V.en
dc.contributor.authorPérez Casal, J.en
dc.contributor.authorNaessens, Janen
dc.contributor.authorWesonga, H.O.en
dc.date.accessioned2015-12-30T11:41:20Zen
dc.date.available2015-12-30T11:41:20Zen
dc.identifier.urihttps://hdl.handle.net/10568/69443
dc.titleExperimental evaluation of inactivated and live attenuated vaccines against Mycoplasma mycoides subsp. Mycoidesen
dcterms.abstractThe current control method for contagious bovine pleuropneumonia (CBPP) in Africa is vaccination with a live, attenuated strain of Mycoplasma mycoides subsp. mycoides(Mmm). However, this method is not very efficient and often causes serious adverse reactions. Several studies have attempted to induce protection using inactivated mycoplasma, but with widely contradictory results. Therefore, we compared the protective capacity of the live T1/44 vaccine with two inactivated preparations of Mmmstrain Afadé, inoculated with an adjuvant. Protection was measured after a challenge with Afadé. The protection levels were 31%, 80.8% and 74.1% for the formalin-inactivated, heat-inactivated and live attenuated preparations, respectively. These findings indicate that low doses of heat-inactivated Mmm can offer protection to a level similar to the current live attenuated (T1/44) vaccine formulation.en
dcterms.accessRightsOpen Access
dcterms.audienceScientistsen
dcterms.bibliographicCitationMwirigi, M., Nkando, I., Aye, R., Soi, R., Ochanda, H., Berberov, E., Potter, A., Gerdts, V., Perez-Casal, J., Naessens, J. and Wesonga, H. 2016. Experimental evaluation of inactivated and live attenuated vaccines against Mycoplasma mycoides subsp. Mycoides. Veterinary Immunology and Immunopathology 169:63–67.en
dcterms.extentp. 63-67en
dcterms.issued2016-01
dcterms.languageen
dcterms.licenseCC-BY-NC-ND-4.0
dcterms.publisherElsevieren
dcterms.subjectanimal diseasesen
dcterms.typeJournal Article

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