Experimental evaluation of inactivated and live attenuated vaccines against Mycoplasma mycoides subsp. Mycoides
| cg.authorship.types | CGIAR and advanced research institute | en_US |
| cg.contributor.affiliation | International Livestock Research Institute | en_US |
| cg.contributor.affiliation | Kenya Agricultural and Livestock Research Organization | en_US |
| cg.contributor.affiliation | University of Nairobi | en_US |
| cg.contributor.affiliation | International Vaccine Centre, Canada | en_US |
| cg.contributor.crp | Livestock and Fish | en_US |
| cg.coverage.region | Africa | en_US |
| cg.creator.identifier | Jan Naessens: 0000-0002-7075-9915 | en_US |
| cg.howPublished | Formally Published | en_US |
| cg.identifier.doi | https://doi.org/10.1016/j.vetimm.2015.12.006 | en_US |
| cg.isijournal | ISI Journal | en_US |
| cg.issn | 0165-2427 | en_US |
| cg.journal | Veterinary Immunology and Immunopathology | en_US |
| cg.reviewStatus | Peer Review | en_US |
| cg.subject.ilri | ANIMAL DISEASES | en_US |
| cg.subject.ilri | CBPP | en_US |
| cg.subject.ilri | DISEASE CONTROL | en_US |
| cg.subject.ilri | LIVESTOCK | en_US |
| cg.subject.ilri | VACCINES | en_US |
| cg.volume | 169 | en_US |
| dc.contributor.author | Mwirigi, M. | en_US |
| dc.contributor.author | Nkando, I. | en_US |
| dc.contributor.author | Aye, R. | en_US |
| dc.contributor.author | Soi, R. | en_US |
| dc.contributor.author | Ochanda, H. | en_US |
| dc.contributor.author | Berberov, E. | en_US |
| dc.contributor.author | Potter, A. | en_US |
| dc.contributor.author | Gerdts, V. | en_US |
| dc.contributor.author | Pérez Casal, J. | en_US |
| dc.contributor.author | Naessens, Jan | en_US |
| dc.contributor.author | Wesonga, H.O. | en_US |
| dc.date.accessioned | 2015-12-30T11:41:20Z | en_US |
| dc.date.available | 2015-12-30T11:41:20Z | en_US |
| dc.identifier.uri | https://hdl.handle.net/10568/69443 | en_US |
| dc.title | Experimental evaluation of inactivated and live attenuated vaccines against Mycoplasma mycoides subsp. Mycoides | en_US |
| dcterms.abstract | The current control method for contagious bovine pleuropneumonia (CBPP) in Africa is vaccination with a live, attenuated strain of Mycoplasma mycoides subsp. mycoides(Mmm). However, this method is not very efficient and often causes serious adverse reactions. Several studies have attempted to induce protection using inactivated mycoplasma, but with widely contradictory results. Therefore, we compared the protective capacity of the live T1/44 vaccine with two inactivated preparations of Mmmstrain Afadé, inoculated with an adjuvant. Protection was measured after a challenge with Afadé. The protection levels were 31%, 80.8% and 74.1% for the formalin-inactivated, heat-inactivated and live attenuated preparations, respectively. These findings indicate that low doses of heat-inactivated Mmm can offer protection to a level similar to the current live attenuated (T1/44) vaccine formulation. | en_US |
| dcterms.accessRights | Open Access | en_US |
| dcterms.audience | Scientists | en_US |
| dcterms.bibliographicCitation | Mwirigi, M., Nkando, I., Aye, R., Soi, R., Ochanda, H., Berberov, E., Potter, A., Gerdts, V., Perez-Casal, J., Naessens, J. and Wesonga, H. 2016. Experimental evaluation of inactivated and live attenuated vaccines against Mycoplasma mycoides subsp. Mycoides. Veterinary Immunology and Immunopathology 169:63–67. | en_US |
| dcterms.extent | p. 63-67 | en_US |
| dcterms.issued | 2016-01 | en_US |
| dcterms.language | en | en_US |
| dcterms.license | CC-BY-NC-ND-4.0 | en_US |
| dcterms.publisher | Elsevier | en_US |
| dcterms.subject | animal diseases | en_US |
| dcterms.type | Journal Article | en_US |
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