The biology of Theileria parva and control of East Coast fever—Current status and future trends

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cg.authorship.typesCGIAR and advanced research instituteen_US
cg.contributor.affiliationInternational Livestock Research Instituteen_US
cg.contributor.affiliationWashington State Universityen_US
cg.contributor.crpLivestock and Fishen_US
cg.creator.identifierVishvanath Nene: 0000-0001-7066-4169en_US
cg.creator.identifierHenry Kiara: 0000-0001-9578-1636en_US
cg.creator.identifierLucilla Steinaa: 0000-0003-3691-3971en_US
cg.creator.identifierNicholas Svitek: 0000-0002-4539-5806en_US
cg.creator.identifierAnna Lacasta: 0000-0001-8381-9844en_US
cg.creator.identifierRoger Pelle: 0000-0003-1053-085Xen_US
cg.howPublishedFormally Publisheden_US
cg.identifier.doihttps://doi.org/10.1016/j.ttbdis.2016.02.001en_US
cg.isijournalISI Journalen_US
cg.issn1877-959Xen_US
cg.issue4en_US
cg.journalTicks and Tick-borne Diseasesen_US
cg.reviewStatusPeer Reviewen_US
cg.speciesTheileria parvaen_US
cg.subject.ilriANIMAL DISEASESen_US
cg.subject.ilriCATTLEen_US
cg.subject.ilriDISEASE CONTROLen_US
cg.subject.ilriECFen_US
cg.subject.ilriLIVESTOCKen_US
cg.subject.ilriVACCINESen_US
cg.volume7en_US
dc.contributor.authorNene, Vishvanath M.en_US
dc.contributor.authorKiara, Henry K.en_US
dc.contributor.authorLacasta, Annaen_US
dc.contributor.authorPelle, Rogeren_US
dc.contributor.authorSvitek, Nicholasen_US
dc.contributor.authorSteinaa, Lucillaen_US
dc.date.accessioned2016-03-20T07:35:57Zen_US
dc.date.available2016-03-20T07:35:57Zen_US
dc.identifier.urihttps://hdl.handle.net/10568/72680en_US
dc.titleThe biology of Theileria parva and control of East Coast fever—Current status and future trendsen_US
dcterms.abstractTremendous progress has been made over the last ten years on East Coast fever (ECF) research. Publication of a reference genome sequence of Theileria parva, the causative agent of ECF, has led to a more thorough characterization of the genotypic and antigenic diversity of the pathogen. It also facilitated identification of antigens that are targets of bovine major histocompatibility complex class I restricted cytotoxic T-lymphocytes (CTLs), induced by a live parasite-based infection and treatment method (ITM) vaccine. This has led to improved knowledge of epitope-specific T-cell responses to ITM that most likely contribute to the phenomenon of strain-specific immunity. The Muguga cocktail ITM vaccine, which provides broad-spectrum immunity to ECF is now a registered product in three countries in eastern Africa. Effort is directed at improving and scaling up the production process to make this vaccine more widely available on a commercial basis in the region. Meanwhile, research to develop a subunit vaccine based on parasite neutralizing antibodies and CTLs has been revived through convening of a research consortium to develop proof-of-concept for a next generation vaccine. Many new scientific and technical advances are facilitating this objective. Hence, the next decade promises even more progress toward an improved control of ECF.en_US
dcterms.accessRightsOpen Accessen_US
dcterms.audienceScientistsen_US
dcterms.bibliographicCitationNene, V., Kiara, H., Lacasta, A., Pelle, R., Svitek, N. and Steinaa, L. 2016. The biology of Theileria parva and control of East Coast fever—Current status and future trends. Ticks and Tick-borne Diseases 7(4):549–564.en_US
dcterms.extentp. 549-564en_US
dcterms.issued2016-06en_US
dcterms.languageenen_US
dcterms.licenseCC-BY-NC-ND-4.0en_US
dcterms.publisherElsevieren_US
dcterms.subjecttheileriaen_US
dcterms.subjectcattleen_US
dcterms.subjectanimal diseasesen_US
dcterms.subjectvaccinesen_US
dcterms.subjectdisease controlen_US
dcterms.subjecteast coast feveren_US
dcterms.typeJournal Articleen_US

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Improved vaccines for the control of East Coast fever in cattle in Africa
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