ACE2 mediates tryptophan alleviation on diarrhea by repairing intestine barrier involved mTOR pathway

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cg.authorship.typesCGIAR and developing country instituteen
cg.contributor.affiliationSouth China Agricultural Universityen
cg.contributor.affiliationZhuhai Tianjiao Technology Co., LTD, Chinaen
cg.contributor.affiliationHunan New Wellful Co., LTD, Chinaen
cg.contributor.affiliationUniversity of Macauen
cg.contributor.affiliationInternational Livestock Research Instituteen
cg.contributor.affiliationUniversity of Agriculture Faisalabaden
cg.contributor.donorNational Science Fund Project of Chinaen
cg.creator.identifierBen Lukuyu: 0000-0002-9374-3553
cg.howPublishedFormally Publisheden
cg.identifier.doihttps://doi.org/10.1186/s11658-024-00603-8en
cg.isijournalISI Journalen
cg.issn1689-1392en
cg.issue1en
cg.journalCellular & Molecular Biology Lettersen
cg.reviewStatusPeer Reviewen
cg.subject.ilriANIMAL HEALTHen
cg.subject.ilriCOVID19en
cg.volume29en
dc.contributor.authorJinze Lien
dc.contributor.authorYingli Yanen
dc.contributor.authorYang Fuen
dc.contributor.authorZhe Chenen
dc.contributor.authorYongjie Yangen
dc.contributor.authorYu Lien
dc.contributor.authorJie Panen
dc.contributor.authorFeiwu Lien
dc.contributor.authorCuifang Zhaen
dc.contributor.authorKai Miaoen
dc.contributor.authorLukuyu, Ben A.en
dc.contributor.authorKashif Saleemi, M.en
dc.contributor.authorYongwen Zhuen
dc.contributor.authorHui Yeen
dc.contributor.authorLin Yangen
dc.contributor.authorWence Wangen
dc.date.accessioned2024-07-16T06:28:57Zen
dc.date.available2024-07-16T06:28:57Zen
dc.identifier.urihttps://hdl.handle.net/10568/149099
dc.titleACE2 mediates tryptophan alleviation on diarrhea by repairing intestine barrier involved mTOR pathwayen
dcterms.abstractThe membrane-delimited receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), angiotensin-converting enzyme 2 (ACE2), which is expressed in the intestine, collaborates with broad neutral amino acid transporter 1 (B0AT1). Tryptophan (Trp) is transported into intestinal epithelial cells by ACE2 and B0AT1. However, whether ACE2 and its binding protein B0AT1 are involved in Trp-mediated alleviation of intestinal injury is largely unknown. Here, we used weaned piglets and IPEC-J2 cells as models and found that ACE2/B0AT1 alleviated lipopolysaccharide (LPS)-induced diarrhea and promoted intestinal barrier recovery via transport of Trp. The levels of the aryl hydrocarbon receptor (AhR) and mechanistic target of rapamycin (mTOR) pathways were altered by ACE2. Dietary Trp supplementation in LPS-treated weaned piglets revealed that Trp alleviated diarrhea by promoting ACE2/B0AT1 expression, and examination of intestinal morphology revealed that the damage to the intestinal barrier was repaired. Our study demonstrated that ACE2 accompanied by B0AT1 mediated the alleviation of diarrhea by Trp through intestinal barrier repair via the mTOR pathway.en
dcterms.accessRightsOpen Access
dcterms.audienceScientistsen
dcterms.available2024-06-14
dcterms.bibliographicCitationJinze Li, Yingli Yan, Yang Fu, Zhe Chen, Yongjie Yang, Yu Li, Jie Pan, Feiwu Li, Cuifang Zha, Kai Miao, Lukuyu, B., Kashif Saleemi, M., Yongwen Zhu, Hui Ye, Lin Yang and Wence Wang. 2024. ACE2 mediates tryptophan alleviation on diarrhea by repairing intestine barrier involved mTOR pathway. Cellular & Molecular Biology Letters 29:90.en
dcterms.issued2024
dcterms.languageen
dcterms.licenseCC-BY-4.0
dcterms.publisherBioMed Centralen
dcterms.subjecttryptophanen
dcterms.subjectanimal healthen
dcterms.subjectCOVID-19en
dcterms.typeJournal Article

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