Gene-modified genotype II live attenuated African swine fever virus induces cross-protection against genotype I but not against genotype IX

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cg.authorship.typesCGIAR and advanced research instituteen
cg.contributor.affiliationPirbright Instituteen
cg.contributor.affiliationInternational Livestock Research Instituteen
cg.contributor.donorBiotechnology and Biological Sciences Research Council, United Kingdomen
cg.contributor.donorGlobal Alliance for Livestock Veterinary Medicinesen
cg.contributor.donorForeign, Commonwealth and Development Office, United Kingdomen
cg.coverage.countryKenya
cg.coverage.iso3166-alpha2KE
cg.coverage.regionAfrica
cg.coverage.regionEastern Africa
cg.creator.identifierJohanneke Dinie Hemmink: 0000-0001-8764-4156en
cg.howPublishedFormally Publisheden
cg.identifier.doihttps://doi.org/10.1080/22221751.2025.2505645en
cg.isijournalISI Journalen
cg.issn2222-1751en
cg.issue1
cg.journalEmerging Microbes and Infectionsen
cg.number2505645
cg.reviewStatusPeer Reviewen
cg.subject.ilriASFen
cg.subject.ilriPIGSen
cg.subject.ilriVACCINESen
cg.subject.impactAreaNutrition, health and food security
cg.subject.sdgSDG 2 - Zero hungeren
cg.volume14
dc.contributor.authorRathakrishnan, A.en
dc.contributor.authorHemmink, Johanneke D.en
dc.contributor.authorPetrovan, V.en
dc.contributor.authorReis, A.L.en
dc.contributor.authorDixon, L.K.en
dc.date.accessioned2025-05-13T06:01:23Zen
dc.date.available2025-05-13T06:01:23Zen
dc.identifier.urihttps://hdl.handle.net/10568/174531
dc.titleGene-modified genotype II live attenuated African swine fever virus induces cross-protection against genotype I but not against genotype IXen
dcterms.abstractAfrican swine fever virus originated in a wildlife cycle in East Africa and spread to domestic pigs. At least twenty-three genotypes are present in Africa whereas only genotypes I and II have spread to other continents. Vaccine development has been directed mainly to genotype II. The ability of genotype II vaccines to induce cross-protection against other genotypes is unknown. Here, we compared cross-protection induced in pigs by an attenuated multiple gene-deleted genotype II modified live vaccine candidate against challenge with different genotypes. Protection against homologous virulent genotype II virus was 100%. Cross-protection against virulent genotype I virus varied between 57 and 71%. However, no protection was achieved against genotype IX challenge. The results indicate potential for use of vaccines in regions where genotypes I and II are circulating.en
dcterms.accessRightsOpen Access
dcterms.audienceAcademicsen
dcterms.audienceScientistsen
dcterms.available2025-05-20en
dcterms.bibliographicCitationRathakrishnan, A., Hemmink, J.D., Petrovan, V., Reis, A.L. and Dixon, L.K. 2025. Gene-modified genotype II live attenuated African swine fever virus induces cross-protection against genotype I but not against genotype IX. Emerging Microbes and Infections 14(1): 2505645.en
dcterms.issued2025en
dcterms.languageen
dcterms.licenseCC-BY-4.0
dcterms.publisherTaylor and Francis Groupen
dcterms.subjectafrican swine feveren
dcterms.subjectswineen
dcterms.subjectvaccinesen
dcterms.typeJournal Article

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