Genome diversity and signatures of selection for production and performance traits in dromedary camels

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cg.authorship.typesCGIAR and developing country instituteen
cg.authorship.typesCGIAR and advanced research instituteen
cg.contributor.affiliationKuwait Universityen
cg.contributor.affiliationUniversity of Khartoumen
cg.contributor.affiliationUniversity of Edinburghen
cg.contributor.affiliationUniversity of Gadarifen
cg.contributor.affiliationKing Faisal Universityen
cg.contributor.affiliationInternational Livestock Research Instituteen
cg.contributor.crpLivestock
cg.contributor.donorAfrican Development Banken
cg.coverage.countrySudan
cg.coverage.iso3166-alpha2SD
cg.coverage.regionAfrica
cg.coverage.regionEastern Africa
cg.coverage.regionNorthern Africa
cg.creator.identifierOlivier Hanotte: 0000-0002-2877-4767
cg.howPublishedFormally Publisheden
cg.identifier.doihttps://doi.org/10.3389/fgene.2019.00893en
cg.isijournalISI Journalen
cg.issn2297-1769en
cg.journalFrontiers in Veterinary Scienceen
cg.reviewStatusPeer Reviewen
cg.subject.ilriANIMAL BREEDINGen
cg.subject.ilriANIMAL PRODUCTSen
cg.subject.ilriBREEDSen
cg.subject.ilriCAMELSen
cg.subject.ilriDAIRYINGen
cg.subject.ilriGENETICSen
cg.subject.ilriLIVESTOCKen
cg.volume10en
dc.contributor.authorBahbahani, Hussainen
dc.contributor.authorMusa H.H.en
dc.contributor.authorWragg, D.en
dc.contributor.authorShuiep, E.S.en
dc.contributor.authorAlmathen, F.en
dc.contributor.authorHanotte, Olivier H.en
dc.date.accessioned2019-11-26T18:31:26Zen
dc.date.available2019-11-26T18:31:26Zen
dc.identifier.urihttps://hdl.handle.net/10568/105902
dc.titleGenome diversity and signatures of selection for production and performance traits in dromedary camelsen
dcterms.abstractDromedary camels (Camelus dromedarius) are single-humped animals found throughout the deserts of Africa, the Arabian Peninsula, and the southwest of Asia. This well-adapted species is mainly used for milk and meat production, although some specific types exhibit superior running performance and are used in racing competitions. However, neither performance nor production camels are bred under intensive genomic selection programs with specific aims to improve these traits. In this study, the full genome sequence data of six camels from the Arabian Peninsula and the genotyping-by-sequencing data of 44 camels (29 packing and 15 racing) from Sudan were analyzed to assess their genome diversities, relationships, and candidate signatures of positive selection. Genome ADMIXTURE and principle component analyses indicate clear geographic separation between the Sudanese and the Arabian Peninsula camels, but with no population-specific genetic distinction within populations. Camel samples from the Arabian Peninsula show higher mean heterozygosity (0.560 ± 0.003) than those from Sudan (0.347 ± 0.003). Analyses of signatures of selection, using pooled heterozygosity (Hp) approach, in the Sudanese camels revealed 176, 189, and 308 candidate regions under positive selection in the combined and packing and racing camel populations, respectively. These regions host genes that might be associated with adaptation to arid environment, dairy traits, energy homeostasis, and chondrogenesis. Eight regions show high genetic differentiation, based on Fst analysis, between the Sudanese packing and racing camel types. Genes associated with chondrogenesis, energy balance, and urinary system development were found within these regions. Our results advocate for further detailed investigation of the genome of the dromedary camel to identify and characterize genes and variants associated with their valuable phenotypic traits. The results of which may support the development of breeding programs to improve the production and performance traits of this unique domesticated species.en
dcterms.accessRightsOpen Access
dcterms.audienceScientistsen
dcterms.available2019-09-19
dcterms.bibliographicCitationBahbahani, H., Musa H.H., Wragg, D., Shuiep, E.S., Almathen, F. and Hanotte, O. 2019. Genome diversity and signatures of selection for production and performance traits in dromedary camels. Frontiers in Veterinary Science 10:893.en
dcterms.issued2019-09-19
dcterms.languageen
dcterms.licenseCC-BY-4.0
dcterms.publisherFrontiers Mediaen
dcterms.subjectcamelsen
dcterms.subjectanimal productsen
dcterms.subjectmilk productionen
dcterms.subjectdairiesen
dcterms.subjectgeneticsen
dcterms.subjectanimal breedingen
dcterms.typeJournal Article

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