Antidiabetic and antioxidant profiling of 67 African trifoliate yam accessions by planar on-surface assays versus in vitro assays
| cg.authorship.types | CGIAR and developing country institute | en |
| cg.contributor.affiliation | University of Ibadan | en |
| cg.contributor.affiliation | International Institute of Tropical Agriculture | en |
| cg.contributor.affiliation | Carl von Ossietzky University Oldenburg | en |
| cg.contributor.affiliation | Justus Liebig University Giessen | en |
| cg.contributor.crp | Roots, Tubers and Bananas | |
| cg.contributor.donor | Alexander von Humboldt-Stiftung | en |
| cg.contributor.donor | German Academic Exchange Service | en |
| cg.contributor.donor | Deutsche Forschungsgemeinschaft | en |
| cg.coverage.country | Nigeria | |
| cg.coverage.iso3166-alpha2 | NG | |
| cg.coverage.region | Africa | |
| cg.coverage.region | Western Africa | |
| cg.creator.identifier | Badara GUEYE: 0000-0003-3157-8772 | en |
| cg.howPublished | Formally Published | en |
| cg.identifier.doi | https://doi.org/10.1016/j.fitote.2024.106299 | en |
| cg.identifier.iitatheme | BIOTECH & PLANT BREEDING | en |
| cg.isijournal | ISI Journal | en |
| cg.issn | 0367-326X | en |
| cg.issue | 106299 | en |
| cg.journal | Fitoterapia | en |
| cg.reviewStatus | Peer Review | en |
| cg.subject.iita | FOOD SECURITY | en |
| cg.subject.iita | FOOD SYSTEMS | en |
| cg.subject.iita | VALUE CHAINS | en |
| cg.subject.iita | YAM | en |
| cg.subject.sdg | SDG 2 - Zero hunger | en |
| cg.volume | 180 | en |
| dc.contributor.author | Aiyedun, P.O. | en |
| dc.contributor.author | Sonibare, M.A. | en |
| dc.contributor.author | Gueye, B. | en |
| dc.contributor.author | Albach, D.C. | en |
| dc.contributor.author | Heil, J. | en |
| dc.contributor.author | Morlock, G.E. | en |
| dc.date.accessioned | 2025-05-09T09:55:04Z | en |
| dc.date.available | 2025-05-09T09:55:04Z | en |
| dc.identifier.uri | https://hdl.handle.net/10568/174510 | |
| dc.title | Antidiabetic and antioxidant profiling of 67 African trifoliate yam accessions by planar on-surface assays versus in vitro assays | en |
| dcterms.abstract | Trifoliate yam (Dioscorea dumetorum) is traditionally used to treat diabetics in Nigeria. However, almost no information is available on its antidiabetic constituents and their natural variance. Hence, the activity of methanolic tuber extracts of 67 trifoliate yam accessions from the largest collection in Africa was proven by four colorimetric antidiabetic and antioxidant in vitro assays, as diabetes is also linked with oxidative stress. For the first time, selected accessions were also analyzed by planar bioactivity profiling. It has a comparatively higher, more differentiated information content, is more sustainable in terms of material consumption, and enables straightforward compound prioritization and characterization. Up to a dozen individual antioxidant zones were revealed as well as one prominent zone inhibiting α-glucosidase and α-amylase. The latter inhibition zone was tentatively assigned to palmitic, linoleic, oleic, linolenic, oxo-nonanoic fatty acids by direct elution to heated electrospray ionization high-resolution mass spectrometry. | en |
| dcterms.accessRights | Open Access | |
| dcterms.audience | Scientists | en |
| dcterms.available | 2024-11-14 | en |
| dcterms.bibliographicCitation | Aiyedun, P.O., Sonibare, M.A., Gueye, B., Albach, D.C., Heil, J. & Morlock, G.E. (2025). Antidiabetic and antioxidant profiling of 67 African trifoliate yam accessions by planar on-surface assays versus in vitro assays. Fitoterapia, 180: 106299, 1-12. | en |
| dcterms.description | Open Access Article | en |
| dcterms.extent | 1-12 | en |
| dcterms.issued | 2025-01 | en |
| dcterms.language | en | |
| dcterms.license | CC-BY-4.0 | |
| dcterms.subject | dioscorea | en |
| dcterms.subject | bioactive properties | en |
| dcterms.subject | chromatography | en |
| dcterms.type | Journal Article |