Ethiopian indigenous goats offer insights into past and recent demographic dynamics and local adaptation in sub-Saharan African goats

cg.authorship.typesCGIAR and developing country instituteen
cg.authorship.typesCGIAR and advanced research instituteen
cg.contributor.affiliationBahir Dar Universityen
cg.contributor.affiliationSwedish University of Agricultural Sciencesen
cg.contributor.affiliationUniversity of Natural Resources and Life Sciences, Viennaen
cg.contributor.affiliationInner Mongolia Agricultural Universityen
cg.contributor.affiliationUniversity of Queenslanden
cg.contributor.affiliationInternational Center for Agricultural Research in the Dry Areasen
cg.contributor.affiliationAddis Ababa Universityen
cg.contributor.affiliationInternational Livestock Research Instituteen
cg.contributor.affiliationUniversity of Edinburghen
cg.contributor.crpLivestock
cg.contributor.donorAfrica Biosciences Challenge Funden
cg.contributor.donorDepartment of Foreign Affairs and Trade, Australiaen
cg.contributor.donorSyngenta Foundation for Sustainable Agricultureen
cg.contributor.donorBill & Melinda Gates Foundationen
cg.contributor.donorDepartment for International Development, United Kingdomen
cg.contributor.donorSwedish International Development Cooperation Agencyen
cg.coverage.countryEthiopia
cg.coverage.iso3166-alpha2ET
cg.coverage.regionAfrica
cg.coverage.regionEastern Africa
cg.creator.identifierGetinet Mekuriaw Tarekegn: 0000-0001-7221-2473
cg.creator.identifierAynalem: 0000-0001-5914-0487
cg.creator.identifierBarbara Rischkowsky: 0000-0002-0035-471X
cg.creator.identifierTadelle Dessie: 0000-0002-1630-0417
cg.creator.identifierAlly Okeyo Mwai: 0000-0003-2379-7801
cg.creator.identifierJoram Mwacharo: 0000-0001-6981-8140
cg.creator.identifierAppolinaire Djikeng: 0000-0001-9271-3419
cg.howPublishedFormally Publisheden
cg.identifier.doihttps://doi.org/10.1111/eva.13118en
cg.isijournalISI Journalen
cg.issn1752-4571en
cg.issue7en
cg.journalEvolutionary Applicationsen
cg.reviewStatusPeer Reviewen
cg.subject.ilriANIMAL BREEDINGen
cg.subject.ilriGOATSen
cg.subject.ilriINDIGENOUS BREEDSen
cg.subject.ilriSMALL RUMINANTSen
cg.volume14en
dc.contributor.authorMekuriaw, Getineten
dc.contributor.authorKhayatzadeh, N.en
dc.contributor.authorLiu, B.en
dc.contributor.authorOsama, S.en
dc.contributor.authorHaile, Aynalemen
dc.contributor.authorRischkowsky, Barbara A.en
dc.contributor.authorZhang, W.en
dc.contributor.authorTesfaye, K.en
dc.contributor.authorDessie, Tadelleen
dc.contributor.authorOkeyo Mwai, Allyen
dc.contributor.authorDjikeng, Appolinaireen
dc.contributor.authorMwacharo, Joram M.en
dc.date.accessioned2020-09-14T08:33:45Zen
dc.date.available2020-09-14T08:33:45Zen
dc.identifier.urihttps://hdl.handle.net/10568/109412
dc.titleEthiopian indigenous goats offer insights into past and recent demographic dynamics and local adaptation in sub-Saharan African goatsen
dcterms.abstractKnowledge on how adaptive evolution and human socio‐cultural and economic interests shaped livestock genomes particularly in sub‐Saharan Africa remains limited. Ethiopia is in a geographic region that has been critical in the history of African agriculture with ancient and diverse human ethnicity and bio‐climatic conditions. Using 52K genome‐wide data analysed in 646 individuals from 13 Ethiopian indigenous goat populations, we observed high levels of genetic variation. Although runs of homozygosity (ROH) were ubiquitous genome‐wide, there were clear differences in patterns of ROH length and abundance and in effective population sizes illustrating differences in genome homozygosity, evolutionary history, and management. Phylogenetic analysis incorporating patterns of genetic differentiation and gene flow with ancestry modelling highlighted past and recent intermixing and possible two deep ancient genetic ancestries that could have been brought by humans with the first introduction of goats in Africa. We observed four strong selection signatures that were specific to Arsi‐Bale and Nubian goats. These signatures overlapped genomic regions with genes associated with morphological, adaptation, reproduction and production traits due possibly to selection under environmental constraints and/or human preferences. The regions also overlapped uncharacterized genes, calling for a comprehensive annotation of the goat genome. Our results provide insights into mechanisms leading to genome variation and differentiation in sub‐Saharan Africa indigenous goats.en
dcterms.accessRightsOpen Access
dcterms.audienceScientistsen
dcterms.available2021-06-15
dcterms.bibliographicCitationMekuriaw, G., Khayatzadeh, N., Liu, B., Osama, S., Haile, A., Rischkowsky, B., Zhang, W., Tesfaye, K., Dessie, T., Okeyo, A.M., Djikeng, A. and Mwacharo, J.M. 2021. Ethiopian indigenous goats offer insights into past and recent demographic dynamics and local adaptation in sub-Saharan African goats. Evolutionary Applications 14(7):1716-1731.en
dcterms.extentp. 1716-1731en
dcterms.issued2021-07
dcterms.languageen
dcterms.licenseCC-BY-4.0
dcterms.publisherWileyen
dcterms.subjectindigenous breedsen
dcterms.subjectgoatsen
dcterms.subjectsmall ruminantsen
dcterms.subjectanimal breedingen
dcterms.typeJournal Article

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