Parasite strain specificity of bovine cytotoxic T cell responses to Theileria parva is determined primarily by immunodominance.

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cg.contributor.affiliationInternational Livestock Research Instituteen
cg.creator.identifierStephen J Kemp: 0000-0003-4041-1720
cg.identifier.doihttps://doi.org/10.4049/jimmunol.155.10.4854en
cg.issn0022-1767en
cg.issn1550-6606en
cg.issue10en
cg.journalJournal of Immunologyen
cg.volume155en
dc.contributor.authorTaracha, E.L.N.en
dc.contributor.authorGoddeeris, B.M.en
dc.contributor.authorTeale, A.J.en
dc.contributor.authorKemp, Stephen J.en
dc.contributor.authorMorrison, W. Ivanen
dc.date.accessioned2024-09-11T09:26:01Zen
dc.date.available2024-09-11T09:26:01Zen
dc.identifier.urihttps://hdl.handle.net/10568/152125
dc.titleParasite strain specificity of bovine cytotoxic T cell responses to Theileria parva is determined primarily by immunodominance.en
dcterms.abstractThe parasite strain specificity of CTL responses to Theileria parva varies among cattle immunized with the same parasite stock. We have investigated the influence of class I MHC on the strain specificity of CTL responses to T. parva in 19 cattle of defined class I phenotype immunized with either of two T. parva populations, in which protection to subsequent reciprocal challenge correlated with CTL strain specificity. In the majority of animals the response was restricted by the products of one MHC haplotype and there was a consistent bias to some haplotypes in preference to others. In 10 of 13 cattle expressing the molecularly defined MHC specificities A10 and KN104 on one haplotype, the CTL response was restricted entirely by this haplotype, thus allowing a precise analysis of the MHC restriction specificities. The MHC restriction specificity and the parasite population used for immunization both influenced the strain specificity of the response. By examining responses in identical twins immunized with different parasites or in animals before and after challenge with heterologous parasites, animals that mounted a strain-specific response to primary infection were shown to be capable of responding to Ags shared by the two parasite populations. These findings indicate that the strain specificity of CTL responses to T. parva is not determined primarily by immune response genes that define the inherent capacity to respond, but rather is a consequence of the response in individual animals being biased toward a limited number of immunodominant peptide-MHC determinants.en
dcterms.accessRightsOpen Access
dcterms.bibliographicCitationTaracha, E. L., Goddeeris, B. M., Teale, A. J., Kemp, S. J., & Morrison, W. I. (1995). Parasite strain specificity of bovine cytotoxic T cell responses to Theileria parva is determined primarily by immunodominance. The Journal of Immunology, 155(10), 4854–4860. https://doi.org/10.4049/jimmunol.155.10.4854en
dcterms.extentpp. 4854-4860en
dcterms.issued1995-11-15
dcterms.languageen
dcterms.publisherThe American Association of Immunologistsen
dcterms.subjectcattleen
dcterms.subjectanalysisen
dcterms.subjecttheileria parvaen
dcterms.subjectgenesen
dcterms.subjectinfectionen
dcterms.subjectparasitesen
dcterms.subjectpopulationen
dcterms.subjectimmunizationen
dcterms.subjectanimalsen
dcterms.subjectimmune responseen
dcterms.subjectproductsen
dcterms.subjectprotectionen
dcterms.subjectbovineen
dcterms.subjectcapacityen
dcterms.subjecthaplotypesen
dcterms.subjectparasiteen
dcterms.typeJournal Article

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