A novel non-canonical rectifying calcium channel in rice triggers cell death mediated robust immunity

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cg.authorship.typesCGIAR and developing country instituteen
cg.contributor.affiliationHunan Agricultural Universityen
cg.contributor.affiliationJilin Agricultural Universityen
cg.contributor.affiliationHuazhong Agricultural Universityen
cg.contributor.affiliationIRRI-JAAS Joint Laben
cg.contributor.affiliationIRRI-CHINA Japonica Rice Research Centeren
cg.contributor.affiliationInternational Rice Research Instituteen
cg.coverage.countryChina
cg.coverage.iso3166-alpha2CN
cg.coverage.regionEastern Asia
cg.howPublishedGrey Literatureen
cg.identifier.doihttps://doi.org/10.21203/rs.3.rs-6155589/v1en
cg.journalResearch Squareen
cg.reviewStatusInternal Reviewen
dc.contributor.authorWu, Junen
dc.contributor.authorLiu, Jianbinen
dc.contributor.authorXiao, Guien
dc.contributor.authorLiu, Haien
dc.contributor.authorLiang, Yien
dc.contributor.authorYi, Zhaofengen
dc.contributor.authorBin, Baien
dc.contributor.authorLiang, Xiushuoen
dc.contributor.authorLuo, Shengen
dc.contributor.authorYang, Jieen
dc.contributor.authorXue, Shaowuen
dc.contributor.authorSun, Wenxianen
dc.contributor.authorZhou, Boen
dc.contributor.authorYuan, Fangen
dc.date.accessioned2025-05-07T09:16:48Zen
dc.date.available2025-05-07T09:16:48Zen
dc.identifier.urihttps://hdl.handle.net/10568/174458
dc.titleA novel non-canonical rectifying calcium channel in rice triggers cell death mediated robust immunityen
dcterms.abstractPlants utilize calcium as a signaling molecule to regulate innate immunity, including PAMP-triggered immunity (PTI) and effector-triggered immunity (ETI), in addition to controlling growth and development1,2. Recent extensive research has highlighted that the activation of calcium ion (Ca2+) channels during PTI and the formation of Ca2+ channels during ETI are crucial for plant immunity3. However, comprehension on how crops substantially augment immunity through the enhancement of Ca2+ channel activity remains limited. Here, we report a rice lesion mimic mutant, called etd1 (elicitors triggered cell death 1), which also triggers cell death formation upon the challenge of rice blast elicitors. The recessive gain-of-function gene etd1 encodes a hypermorphic haplotype of OsCNGC13 which contains a single amino acid substitution of glycine-to-glutamate at the position of 483rd amino acid. The etd1 forms a novel non-canonical rectifying Ca2+ channel that significantly enhances Ca2+ influx. We position that etd1-driven excessive Ca2+ influx disrupts cellular calcium homeostasis, thereby triggering pathogen-induced cell death and conferring robust and broad-spectrum immunity to the rice blast pathogen.en
dcterms.accessRightsOpen Access
dcterms.audienceAcademicsen
dcterms.audienceCGIARen
dcterms.audienceDevelopment Practitionersen
dcterms.audienceScientistsen
dcterms.available2025-03-27en
dcterms.bibliographicCitationWu, Jun, Jianbin Liu, Gui Xiao, Hai Liu, Yi Liang, Zhaofeng Yi, Bai Bin et al. "A Novel Non-Canonical Rectifying Calcium Channel in Rice Triggers Cell Death Mediated Robust Immunity." [Pre-print](2025).en
dcterms.extent18 p.en
dcterms.issued2025-03-27en
dcterms.languageen
dcterms.licenseCC-BY-4.0
dcterms.publisherSpringer Science and Business Media LLCen
dcterms.subjectcalciumen
dcterms.subjectcell deathen
dcterms.subjectmutantsen
dcterms.subjectplant diseasesen
dcterms.subjectgene expressionen
dcterms.subjectinnate immunityen
dcterms.subjection channelsen
dcterms.subjecthomeostasisen
dcterms.subjecthaplotypesen
dcterms.subjectgenetic variationen
dcterms.subjectgenetic resistanceen
dcterms.typePreprint

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