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Item Theileria parva: influence of vector, parasite and host relationships on the epidemiology of theileriosis in southern Africa(Journal Article, 1991-06) Norval, R.A.I.; Lawrence, J. A.; Young, A.S.; Perry, Brian D.; Dolan, T. T.; Scott, J.The protozoan parasite Theileria parva, transmitted by the ixodid tick Rhipicephalus appendiculatus, is the cause of East Coast fever (ECF) and the related syndromes of Corridor disease and January disease in cattle of eastern, central and southern Africa. It is likely that buffalo (Syncerus caffer) are the natural host of T. parva. In eastern and southern Africa, there exist both buffalo-adapted and cattle-adapted T. parva. Disease caused by buffalo-adapted parasites is called Corridor disease, and that caused by cattle-adapted parasites is termed East Coast fever. In eastern Africa, it has been shown experimentally that buffalo-adapted T. parva can, after serial passage in cattle, become adapted to cattle, in which it can then be maintained and cause ECF. This adaptation has been termed transformation. The transformation of buffalo-adapted T. parva to a cattle-adapted parasite has not been reported in southern Africa, and ECF, eradicated from South Africa, Swaziland and southern Mozambique by 1960, has not reappeared in the subcontinent. This paper discusses the possible reasons for this, and hypothesizes that vector population dynamics and the susceptibility of the vector population to infection with T. parva are among the most important factors which influence the expression of ECF as a disease entity, and the likelihood of transformation occurring. It also considers the possibility that disappearance of ECF from southern Africa resulted from the extinction, as a result of vigorous control measures and unfavourable climatic conditions, of non-diapausing populations of R. appendiculatus that may have been introduced from eastern Africa with cattle imported in 1901.Item Interference with anti-trypanosome immune responses in rabbits infected with cyclically-transmitted Trypanosoma congolense(Journal Article, 1983-11) LUCKINS, A.G.; GRAY, A.R.Summary Rabbits were infected with two clones of antigenically distinct stocks of Trypanosoma congolense transmitted through Glossina morsitans. Local skin reaction development and the appearance of neutralizing antibodies were followed in animals infected with one or other of the trypanosome stocks, with both stocks simultaneously or with both stocks consecutively. There was little difference in local skin reaction development on rabbits infected with a single stock or with both stocks simultaneously but, in rabbits exposed to a heterologous stock 14 or 21 days after a primary infection reactions were reduced in size or completely absent. Neutralizing antibodies against metacyclic‐derived trypano‐somes were detected 21 days after infection in animals infected with a single trypanosome stock and, in rabbits infected with both stocks simultaneously, antibodies against each stock were also detected 21 to 28 days after infection. In rabbits challenged 14 or 21 days after primary infection the appearance of trypanocidal antibodies against the stock used for challenge was delayed from 28 to 49 days.Item Endoplasmic reticulum contains a common, abundant calcium-binding glycoprotein, endoplasmin(Journal Article, 1986-12-01) Koch, G.; Smith, M.; Macer, D.; Webster, P.; Mortara, R.The most abundant protein in microsomal membrane preparations from mammalian cells has been identified as a 100 × 103Mr concanavalin A-binding glycoprotein. The glycosyl moiety of the glycoprotein is completely sensitive to endoglycosidase H, suggesting a predominantly endoplasmic reticulum localization in the cell. Using a monospecific antibody it was shown by binding and immunofluorescence studies that the glycoprotein is intracellular. Immunoelectron microscopy showed that the glycoprotein was at least 100 times more concentrated in the endoplasmic reticulum than in any other cellular organelle. It was found to be substantially overexpressed in cells and tissues rich in endoplasmic reticulum. Since it is the major common protein component associated with the endoplasmic reticulum we refer to it as endoplasmin. Calcium-binding studies show that endoplasmin is a major calcium-binding protein in cells, suggesting that at least one of its roles might be in the calcium-storage function of the endoplasmic reticulum. The amino-terminal sequence of endoplasmin is identical to that of a 100 × 103Mr stress-related protein.Item A characterization of mRNA activities and their sequence complexities in Trypanosoma brucei: partial purification and properties of the VSSA mRNA(Journal Article, 1978) Williams, R.O.; Marcu, Kenneth B.; Young, J.R.; Rovis, Luciana; Williams, Sally C.Item Scavenging poultry for poverty alleviation: A review of experiences with a focus on Bangladesh(Report, 2003-06) Fakhrul Islam, S.M.; Jabbar, M.A.Item Development of strategies to promote farmer utilisation of herbaceous legumes for natural resource management: Final Report(Report, 2003) Deutsche Gesellschaft für Internationale ZusammenarbeitItem Techniques de transformation du lait fermente(Training Material, 1992) O'Connor, C.B.; Tripathi, B.R.Item ILRAD Research and Traning Activies 1979(Report, 1979) International Laboratory for Research on Animal DiseasesItem Programme and Abstracts Programme et Abreges(Conference Proceedings, 1988) International Livestock Centre for AfricaItem Epidemiologie et economie veterinaires en Afrique. Manuel a l'usage des planificateurs de la sante animale(Training Material, 1987-01) Putt, S.N.H.; Shaw, A.P.M.; Woods, A.J.; Tyler, L.; James, A.D.Item IDEAS: Un Progiciel Pour Micro-Ordinateur Destine a L'ecvaluation Complete des Performances Animales Dans les Situations de Production Africaines, volume 2(Manual) International Livestock Centre for AfricaItem La production animale au Mali central(Report, 1988) Wilson, R.T.Item Theileriosis(Conference Proceedings, 1977) Henson, J.B.; Campbell, M.Item Inauguration Symposium on Current Trends in Immunology and Genetics and Their Implications for Parasitic Diseases(Book, 1978) International Laboratory for Research on Animal DiseasesItem Productivité de bovins laitiers métis dans la région d'Arsi en Ethiopie(Report, 1986) Kiwuwa, G.H.; Trail, J.C.M.; Yousef, M.K.; Worku, G.; Anderson, F.M.; Durkin, J.W.Item Le chameau (Camelus dromedarius)(Book, 1985) Mukasa-Mugerwa, E.Item Policy Options Promoting Market Participation of Smallholder Livestock Producers(Report, 2002) Lapar, Ma. Lucila; Holloway, G.J.; Ehui, Simeon K.Item The African Trypanotolerant Livestock Network(Book, 1996) Mani, R.I.; Kaufmann, Ralph R. vonItem Land Degradation and Strategies for Sustainable Land Management in the Ethiopian Highlands(Working Paper, 2002) Hagos, Fitsum; Pender, J.L.; Gebreselassie, N.Item ILRAD Annual scientific report 1989(Report, 1990) International Laboratory for Research on Animal Diseases