Clinical evaluation of corridor disease in Bos indicus (Boran) cattle naturally infected with buffalo-derived Theileria parva

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cg.authorship.typesCGIAR and developing country instituteen_US
cg.authorship.typesCGIAR and advanced research instituteen_US
cg.contributor.affiliationInternational Livestock Research Instituteen_US
cg.contributor.affiliationOl Pejeta Conservancy, Kenyaen_US
cg.contributor.affiliationUniversity of Edinburghen_US
cg.contributor.crpLivestocken_US
cg.contributor.donorBiotechnology and Biological Sciences Research Council, United Kingdomen_US
cg.contributor.donorBill & Melinda Gates Foundationen_US
cg.contributor.donorForeign, Commonwealth and Development Office, United Kingdomen_US
cg.creator.identifierElizabeth Cook: 0000-0001-6081-8363en_US
cg.creator.identifierTatjana Sitt: 0000-0001-7104-2345en_US
cg.creator.identifierElizabeth Jane Poole: 0000-0002-8570-794Xen_US
cg.creator.identifierJames Prendergast: 0000-0001-8916-018Xen_US
cg.creator.identifierPhilip Toye: 0000-0002-7100-2789en_US
cg.creator.identifierAntoinette Aluoch: 0000-0001-7197-7837en_US
cg.howPublishedFormally Publisheden_US
cg.identifier.doihttps://doi.org/10.3389/fvets.2021.731238en_US
cg.isijournalISI Journalen_US
cg.issn2297-1769en_US
cg.journalFrontiers in Veterinary Scienceen_US
cg.reviewStatusPeer Reviewen_US
cg.subject.ilriANIMAL DISEASESen_US
cg.subject.ilriBUFFALOen_US
cg.subject.ilriCATTLEen_US
cg.subject.ilriDISEASE CONTROLen_US
cg.subject.ilriECFen_US
cg.volume8en_US
dc.contributor.authorCook, Elizabeth A.J.en_US
dc.contributor.authorSitt, Tatjanaen_US
dc.contributor.authorPoole, Elizabeth J.en_US
dc.contributor.authorNdambuki, Gideon M.en_US
dc.contributor.authorMwaura, Stephenen_US
dc.contributor.authorChepkwony, M.C.en_US
dc.contributor.authorLatré de Laté, Perleen_US
dc.contributor.authorMiyunga, Antoinetteen_US
dc.contributor.authorAardt, Richard vanen_US
dc.contributor.authorPrettejohn, G.en_US
dc.contributor.authorWragg, D.en_US
dc.contributor.authorPrendergast, J.G.D.en_US
dc.contributor.authorMorrison, W.I.en_US
dc.contributor.authorToye, Philip G.en_US
dc.date.accessioned2021-10-28T08:57:59Zen_US
dc.date.available2021-10-28T08:57:59Zen_US
dc.identifier.urihttps://hdl.handle.net/10568/115722en_US
dc.titleClinical evaluation of corridor disease in Bos indicus (Boran) cattle naturally infected with buffalo-derived Theileria parvaen_US
dcterms.abstractCorridor disease (CD) is a fatal condition of cattle caused by buffalo-derived Theileria parva. Unlike the related condition, East Coast fever, which results from infection with cattle-derived T. parva, CD has not been extensively studied. We describe in detail the clinical and laboratory findings in cattle naturally infected with buffalo-derived T. parva. Forty-six cattle were exposed to buffalo-derived T. parva under field conditions at the Ol Pejeta Conservancy, Kenya, between 2013 and 2018. The first signs of disease observed in all animals were nasal discharge (mean day of onset was 9 days post-exposure), enlarged lymph nodes (10 days post-exposure), and pyrexia (13.7 days post-exposure). Coughing and labored breathing were observed in more than 50% of animals (14 days post-exposure). Less commonly observed signs, corneal edema (22%) and diarrhea (11%), were observed later in the disease progression (19 days post-exposure). All infections were considered clinically severe, and 42 animals succumbed to infection. The mean time to death across all studies was 18.4 days. The mean time from onset of clinical signs to death was 9 days and from pyrexia to death was 4.8 days, indicating a relatively short duration of clinical illness. There were significant relationships between days to death and the days to first temperature (chi2 = 4.00, p = 0.046), and days to peak temperature (chi2 = 25.81, p = 0.001), animals with earlier onset pyrexia died sooner. These clinical indicators may be useful for assessing the severity of disease in the future. All infections were confirmed by the presence of macroschizonts in lymph node biopsies (mean time to parasitosis was 11 days). Piroplasms were detected in the blood of two animals (4%) and 20 (43%) animals seroconverted. In this study, we demonstrate the successful approach to an experimental field study for CD in cattle. We also describe the clinical progression of CD in naturally infected cattle, including the onset and severity of clinical signs and pathology. Laboratory diagnoses based on examination of blood samples are unreliable, and alternatives may not be available to cattle keepers. The rapid development of CD requires recognition of the clinical signs, which may be useful for early diagnosis of the disease and effective intervention for affected animals.en_US
dcterms.accessRightsOpen Accessen_US
dcterms.audienceScientistsen_US
dcterms.available2021-09-29en_US
dcterms.bibliographicCitationCook, E.A.J., Sitt, T., Poole, E.J., Ndambuki, G., Mwaura, S., Chepkwony, M.C., Latre de Late, P., Miyunga, A.A., van Aardt, R., Prettejohn, G., Wragg, D., Prendergast, J.G.D., Morrison, W.I. and Toye, P. 2021. Clinical evaluation of corridor disease in Bos indicus (Boran) cattle naturally infected with buffalo-derived Theileria parva. Frontiers in Veterinary Science 8:731238.en_US
dcterms.issued2021-09-29en_US
dcterms.languageenen_US
dcterms.licenseCC-BY-4.0en_US
dcterms.publisherFrontiers Mediaen_US
dcterms.subjectanimal diseasesen_US
dcterms.subjectcattleen_US
dcterms.subjectdisease controlen_US
dcterms.subjectwater buffaloesen_US
dcterms.subjecteast coast feveren_US
dcterms.typeJournal Articleen_US

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