Clinical evaluation of corridor disease in Bos indicus (Boran) cattle naturally infected with buffalo-derived Theileria parva

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cg.authorship.typesCGIAR and developing country instituteen
cg.authorship.typesCGIAR and advanced research instituteen
cg.contributor.affiliationInternational Livestock Research Instituteen
cg.contributor.affiliationOl Pejeta Conservancy, Kenyaen
cg.contributor.affiliationUniversity of Edinburghen
cg.contributor.crpLivestock
cg.contributor.donorBiotechnology and Biological Sciences Research Council, United Kingdomen
cg.contributor.donorBill & Melinda Gates Foundationen
cg.contributor.donorForeign, Commonwealth and Development Office, United Kingdomen
cg.creator.identifierElizabeth Cook: 0000-0001-6081-8363en
cg.creator.identifierTatjana Sitt: 0000-0001-7104-2345en
cg.creator.identifierElizabeth Jane Poole: 0000-0002-8570-794Xen
cg.creator.identifierJames Prendergast: 0000-0001-8916-018Xen
cg.creator.identifierPhilip Toye: 0000-0002-7100-2789en
cg.creator.identifierAntoinette Aluoch: 0000-0001-7197-7837en
cg.howPublishedFormally Publisheden
cg.identifier.doihttps://doi.org/10.3389/fvets.2021.731238en
cg.isijournalISI Journalen
cg.issn2297-1769en
cg.journalFrontiers in Veterinary Scienceen
cg.reviewStatusPeer Reviewen
cg.subject.ilriANIMAL DISEASESen
cg.subject.ilriBUFFALOen
cg.subject.ilriCATTLEen
cg.subject.ilriDISEASE CONTROLen
cg.subject.ilriECFen
cg.volume8en
dc.contributor.authorCook, Elizabeth A.J.en
dc.contributor.authorSitt, Tatjanaen
dc.contributor.authorPoole, Elizabeth J.en
dc.contributor.authorNdambuki, Gideon M.en
dc.contributor.authorMwaura, Stephenen
dc.contributor.authorChepkwony, M.C.en
dc.contributor.authorLatré de Laté, Perleen
dc.contributor.authorMiyunga, Antoinetteen
dc.contributor.authorAardt, Richard vanen
dc.contributor.authorPrettejohn, G.en
dc.contributor.authorWragg, D.en
dc.contributor.authorPrendergast, J.G.D.en
dc.contributor.authorMorrison, W.I.en
dc.contributor.authorToye, Philip G.en
dc.date.accessioned2021-10-28T08:57:59Zen
dc.date.available2021-10-28T08:57:59Zen
dc.identifier.urihttps://hdl.handle.net/10568/115722
dc.titleClinical evaluation of corridor disease in Bos indicus (Boran) cattle naturally infected with buffalo-derived Theileria parvaen
dcterms.abstractCorridor disease (CD) is a fatal condition of cattle caused by buffalo-derived Theileria parva. Unlike the related condition, East Coast fever, which results from infection with cattle-derived T. parva, CD has not been extensively studied. We describe in detail the clinical and laboratory findings in cattle naturally infected with buffalo-derived T. parva. Forty-six cattle were exposed to buffalo-derived T. parva under field conditions at the Ol Pejeta Conservancy, Kenya, between 2013 and 2018. The first signs of disease observed in all animals were nasal discharge (mean day of onset was 9 days post-exposure), enlarged lymph nodes (10 days post-exposure), and pyrexia (13.7 days post-exposure). Coughing and labored breathing were observed in more than 50% of animals (14 days post-exposure). Less commonly observed signs, corneal edema (22%) and diarrhea (11%), were observed later in the disease progression (19 days post-exposure). All infections were considered clinically severe, and 42 animals succumbed to infection. The mean time to death across all studies was 18.4 days. The mean time from onset of clinical signs to death was 9 days and from pyrexia to death was 4.8 days, indicating a relatively short duration of clinical illness. There were significant relationships between days to death and the days to first temperature (chi2 = 4.00, p = 0.046), and days to peak temperature (chi2 = 25.81, p = 0.001), animals with earlier onset pyrexia died sooner. These clinical indicators may be useful for assessing the severity of disease in the future. All infections were confirmed by the presence of macroschizonts in lymph node biopsies (mean time to parasitosis was 11 days). Piroplasms were detected in the blood of two animals (4%) and 20 (43%) animals seroconverted. In this study, we demonstrate the successful approach to an experimental field study for CD in cattle. We also describe the clinical progression of CD in naturally infected cattle, including the onset and severity of clinical signs and pathology. Laboratory diagnoses based on examination of blood samples are unreliable, and alternatives may not be available to cattle keepers. The rapid development of CD requires recognition of the clinical signs, which may be useful for early diagnosis of the disease and effective intervention for affected animals.en
dcterms.accessRightsOpen Access
dcterms.audienceScientistsen
dcterms.available2021-09-29en
dcterms.bibliographicCitationCook, E.A.J., Sitt, T., Poole, E.J., Ndambuki, G., Mwaura, S., Chepkwony, M.C., Latre de Late, P., Miyunga, A.A., van Aardt, R., Prettejohn, G., Wragg, D., Prendergast, J.G.D., Morrison, W.I. and Toye, P. 2021. Clinical evaluation of corridor disease in Bos indicus (Boran) cattle naturally infected with buffalo-derived Theileria parva. Frontiers in Veterinary Science 8:731238.en
dcterms.issued2021-09-29en
dcterms.languageen
dcterms.licenseCC-BY-4.0
dcterms.publisherFrontiers Mediaen
dcterms.subjectanimal diseasesen
dcterms.subjectcattleen
dcterms.subjectdisease controlen
dcterms.subjectwater buffaloesen
dcterms.subjecteast coast feveren
dcterms.typeJournal Article

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