The potential of Rhipicephalus microplus as a vector of Ehrlichia ruminantium in West Africa

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cg.authorship.typesCGIAR and developing country instituteen_US
cg.authorship.typesCGIAR and advanced research instituteen_US
cg.contributor.affiliationCentre International de Recherche-Développement sur l'Élevage en zone Subhumide, Burkina Fasoen_US
cg.contributor.affiliationUniversité Nazi Bonien_US
cg.contributor.affiliationInternational Livestock Research Instituteen_US
cg.contributor.affiliationUniversité Dan Dicko Dan Koulodoen_US
cg.contributor.affiliationCentre de Coopération Internationale en Recherche Agronomique Pour le Développementen_US
cg.contributor.donorInternational Foundation of Scienceen_US
cg.contributor.donorInternational Mixed Laboratory on Vector-borne Diseasesen_US
cg.coverage.regionAfricaen_US
cg.coverage.regionWestern Africaen_US
cg.creator.identifierNaftaly Githaka: 0000-0003-4530-7164en_US
cg.howPublishedFormally Publisheden_US
cg.identifier.doihttps://doi.org/10.1016/j.ttbdis.2022.102117en_US
cg.isijournalISI Journalen_US
cg.issn1877-959Xen_US
cg.issue2en_US
cg.journalTicks and Tick-borne Diseasesen_US
cg.reviewStatusPeer Reviewen_US
cg.speciesRhipicephalus microplusen_US
cg.speciesEhrlichia ruminantiumen_US
cg.subject.ilriANIMAL DISEASESen_US
cg.subject.ilriLIVESTOCKen_US
cg.subject.impactAreaNutrition, health and food securityen_US
cg.subject.sdgSDG 2 - Zero hungeren_US
cg.volume14en_US
dc.contributor.authorSome, M.V.en_US
dc.contributor.authorBiguezoton, A.S.en_US
dc.contributor.authorGithaka, Naftaly W.en_US
dc.contributor.authorAdakal, H.en_US
dc.contributor.authorDayo, G.-K.en_US
dc.contributor.authorBelem, A.en_US
dc.contributor.authorZoungrana, S.en_US
dc.contributor.authorStachurski, F.en_US
dc.contributor.authorChevillon, C.en_US
dc.date.accessioned2023-01-06T15:46:30Zen_US
dc.date.available2023-01-06T15:46:30Zen_US
dc.identifier.urihttps://hdl.handle.net/10568/126659en_US
dc.titleThe potential of Rhipicephalus microplus as a vector of Ehrlichia ruminantium in West Africaen_US
dcterms.abstractHeartwater, or cowdriosis, is a virulent tick-borne rickettsial disease of ruminants caused by Ehrlichia ruminantium, biologically transmitted by Amblyomma species (A. variegatum in West Africa). In West Africa, this bacterium was recently reported to naturally infect the invasive cattle tick, Rhipicephalus microplus (Rm) through trans-ovarian transmission from replete adult females to offspring. A ‘sheep-tick-sheep’ cycle was set up to determine whether feeding the progeny of these ticks on naïve sheep could lead to infection, and to compare clinical outcomes resulting from this transmission with those observed following infection by the natural A. variegatum (Av) vector. Using local strains of ticks (KIMINI-Rm and KIMINI-Av) and of E. ruminantium (BK242), we recorded, using the PCR technique, the presence of bacterial DNA in ticks (larvae for Av and females for Rm) engorged on sheep inoculated by BK242-infected blood. The bacterial DNA was also detected in the next stages of the lifecycle of R. microplus (eggs and larvae), and in sheep infested either by those R. microplus larvae or by A. variegatum nymphs moulted from larvae engorged on blood-inoculated sheep. Bacterial infection in these sheep was demonstrated by detecting antibodies to E. ruminantium using the MAP1-B ELISA and by isolation of the bacterium on cell culture from blood. The sequences of PCS20 gene detected in ticks and sheep were identical to that of the BK242 strain. Our results confirm that R. microplus can acquire and transmit E. ruminantium to the next stage. However, this transmission resulted in a mild subclinical disease whereas severe clinical disease was observed in sheep infested by A. variegatum infected nymphs, suggesting differences in the tick/bacteria relationship. Future studies will focus on replicating these findings with ticks of different isolates and life stages to determine if R. microplus is playing a role in the epidemiology of heartwater in West Africa. Additionally, studies will investigate whether sheep that are seropositive due to infestation by E. ruminantium-infected R. microplus are subsequently protected against heartwater. Such data will add to our understanding of the possible impact of R. microplus in areas where it has become recently established.en_US
dcterms.accessRightsOpen Accessen_US
dcterms.audienceAcademicsen_US
dcterms.audienceScientistsen_US
dcterms.bibliographicCitationSome, M.V., Biguezoton, A.S., Githaka, N., Adakal, H., Dayo, G.-K., Belem, A., Zoungrana, S., Stachurski, F. and Chevillon, C. 2023. The potential of Rhipicephalus microplus as a vector of Ehrlichia ruminantium in West Africa. Ticks and Tick-borne Diseases 14(2): 102117.en_US
dcterms.extent102117en_US
dcterms.issued2023-03en_US
dcterms.languageenen_US
dcterms.licenseCC-BY-NC-ND-4.0en_US
dcterms.publisherElsevieren_US
dcterms.subjectanimal diseasesen_US
dcterms.subjectlivestocken_US
dcterms.subjectheartwateren_US
dcterms.subjectinfectious diseasesen_US
dcterms.subjectmicrobiologyen_US
dcterms.subjectparasitologyen_US
dcterms.typeJournal Articleen_US

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