Goat seropositivity as an indicator of Rift Valley fever (RVF) infection in human populations: A case-control study of the 2018 Rift Valley fever outbreak in Wajir County, Kenya

Simple item page
cg.authorship.typesCGIAR and developing country instituteen_US
cg.authorship.typesCGIAR and advanced research instituteen_US
cg.contributor.affiliationInternational Livestock Research Instituteen_US
cg.contributor.affiliationUniversity of Liègeen_US
cg.contributor.affiliationUniversity of Liverpoolen_US
cg.contributor.affiliationWajir County Governmenten_US
cg.contributor.affiliationTurkana County Governmenten_US
cg.contributor.affiliationUniversity of Nairobien_US
cg.contributor.affiliationUniversity of Glasgowen_US
cg.contributor.donorGlobal Challenges Research Funden_US
cg.contributor.donorUK Research and Innovationen_US
cg.contributor.donorBiotechnology and Biological Sciences Research Council, United Kingdomen_US
cg.coverage.countryKenyaen_US
cg.coverage.iso3166-alpha2KEen_US
cg.coverage.regionAfricaen_US
cg.coverage.regionEastern Africaen_US
cg.creator.identifierLisa Cavalerie: 0000-0001-7187-3800en_US
cg.creator.identifierElizabeth Cook: 0000-0001-6081-8363en_US
cg.creator.identifierEric M. Fèvre: 0000-0001-8931-4986en_US
cg.howPublishedFormally Publisheden_US
cg.identifier.doihttps://doi.org/10.1016/j.onehlt.2024.100921en_US
cg.isijournalISI Journalen_US
cg.issn2352-7714en_US
cg.journalOne Healthen_US
cg.reviewStatusPeer Reviewen_US
cg.subject.actionAreaResilient Agrifood Systemsen_US
cg.subject.ilriGOATSen_US
cg.subject.ilriHUMAN HEALTHen_US
cg.subject.ilriRVFen_US
cg.subject.ilriSMALL RUMINANTSen_US
cg.subject.ilriZOONOTIC DISEASESen_US
cg.subject.impactAreaNutrition, health and food securityen_US
cg.subject.impactPlatformNutrition, Health and Food Securityen_US
cg.subject.sdgSDG 3 - Good health and well-beingen_US
cg.volume19en_US
dc.contributor.authorOmani, Ruthen_US
dc.contributor.authorCavalerie, Lisaen_US
dc.contributor.authorDaud, A.en_US
dc.contributor.authorCook, Elizabeth A.J.en_US
dc.contributor.authorNakadio, Ereniusen_US
dc.contributor.authorFèvre, Eric M.en_US
dc.contributor.authorGitao, G.en_US
dc.contributor.authorRobinson, J.en_US
dc.contributor.authorNanyingi, M.en_US
dc.contributor.authorBaylis, M.en_US
dc.contributor.authorKimeli, P.en_US
dc.contributor.authorOnono, J.en_US
dc.date.accessioned2024-10-24T04:56:48Zen_US
dc.date.available2024-10-24T04:56:48Zen_US
dc.identifier.urihttps://hdl.handle.net/10568/155550en_US
dc.titleGoat seropositivity as an indicator of Rift Valley fever (RVF) infection in human populations: A case-control study of the 2018 Rift Valley fever outbreak in Wajir County, Kenyaen_US
dcterms.abstractRift Valley fever (RVF) is a viral zoonosis, which is considered as a threat to food security in the Horn of Africa. In Kenya, RVF is the 5th ranked priority zoonotic disease due to its high morbidity and mortality, frequent outbreak events, and associated socioeconomic impacts during outbreak events. In 2018, an RVF outbreak was confirmed in Kenya's Siaya, Wajir, and Marsabit counties. During this outbreak, 30 people were confirmed infected with RVF through laboratory tests; 21 in Wajir, 8 in Marsabit, and 1 in Siaya Counties. Seventy-five (75) households (15 cases and 60 controls) were selected and interviewed using a case-control study design in 2021 (?). A case was a household with a member who was diagnosed with RVF in 2018. In addition, a total of 1029 animals were purposively selected within these households and serologically tested for RVF. The study aimed to estimate the contribution of various risk factors to RVF human occurrence in Kenya with a special focus on Wajir County. Wajir County was chosen due to high number of confirmed human cases reported in the 2018 outbreak. A univariable regression model revealed that owner-reported RVF virus exposure in livestock significantly increased the odds of an RVF human case in the household by 32.7 times (95 % CI 4.0–267.4). The respondent being linked to a goat flock that was IgG-positive increased the odds of an RVF human case by 3.8 times (95 % CI 1.17–12.3). In the final multivariable analysis, the respondent being linked to their own animals affected by RVF increased odds of having an RVF human case in the household by 56.9 times (95 % CI 4.6–700.4), while the respondent being linked to a neighbor household member affected decreased odds of having a RVF human case by 0.1 times (95 % CI 0.08–0.75). In summary, these results have revealed a potential link for the spread of RVF infection from animals to humans in pastoralist households, hence it is critical to carry out targeted, community education, One Health surveillance, prevention, and control measures against the disease. This will be critical to protecting humans against potential spillovers of infections during outbreak events in livestock.en_US
dcterms.accessRightsOpen Accessen_US
dcterms.audienceAcademicsen_US
dcterms.audienceScientistsen_US
dcterms.available2024-10-21en_US
dcterms.bibliographicCitationOmani, R., Cavalerie, L., Daud, A., Cook, E.A.J., Nakadio, E., Fèvre, E.M., Gitao, G., Robinson, J., Nanyingi, M., Baylis, M., Kimeli, P. and Onono, J. 2024. Goat seropositivity as an indicator of Rift Valley fever (RVF) infection in human populations: A case-control study of the 2018 Rift Valley fever outbreak in Wajir County, Kenya. One Health 19: 100921.en_US
dcterms.extent100921en_US
dcterms.issued2024-12en_US
dcterms.languageenen_US
dcterms.licenseCC-BY-4.0en_US
dcterms.publisherElsevieren_US
dcterms.subjectgoatsen_US
dcterms.subjecthealthen_US
dcterms.subjectrift valley feveren_US
dcterms.subjectsmall ruminantsen_US
dcterms.subjectzoonosesen_US
dcterms.typeJournal Articleen_US

Files

License bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.75 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

ILRI articles in journals
ILRI animal and human health program outputs (2017-2024)
One Health regional network for the Horn of Africa (HORN)