Universal tick vaccines: Candidates and remaining challenges

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cg.authorship.typesCGIAR and developing country instituteen_US
cg.authorship.typesCGIAR and advanced research instituteen_US
cg.contributor.affiliationUniversidade Federal do Rio Grande do Sulen_US
cg.contributor.affiliationInternational Livestock Research Instituteen_US
cg.contributor.affiliationUniversidade Federal do Rio de Janeiroen_US
cg.contributor.affiliationChinese Academy of Agricultural Sciencesen_US
cg.contributor.affiliationHokkaido Universityen_US
cg.contributor.donorConselho Nacional de Desenvolvimento Científico e Tecnológicoen_US
cg.contributor.donorCoordenação de Aperfeiçoamento de Pessoal de Nível Superior, Brazilen_US
cg.contributor.donorFundação de Amparo à Pesquisa do Estado do Rio Grande do Sul, Brazilen_US
cg.creator.identifierNaftaly Githaka: 0000-0003-4530-7164en_US
cg.howPublishedFormally Publisheden_US
cg.identifier.doihttps://doi.org/10.3390/ani13122031en_US
cg.isijournalISI Journalen_US
cg.issn2076-2615en_US
cg.issue12en_US
cg.journalAnimalsen_US
cg.reviewStatusPeer Reviewen_US
cg.subject.ilriVACCINESen_US
cg.subject.impactAreaNutrition, health and food securityen_US
cg.subject.sdgSDG 2 - Zero hungeren_US
cg.volume13en_US
dc.contributor.authorParizi, L.F.en_US
dc.contributor.authorGithaka, Naftaly W.en_US
dc.contributor.authorLogullo, C.en_US
dc.contributor.authorZhou, J.en_US
dc.contributor.authorOnuma, M.en_US
dc.contributor.authorTermignoni, C.en_US
dc.contributor.authorSilva Vaz, I. daen_US
dc.date.accessioned2023-06-26T08:58:53Zen_US
dc.date.available2023-06-26T08:58:53Zen_US
dc.identifier.urihttps://hdl.handle.net/10568/130866en_US
dc.titleUniversal tick vaccines: Candidates and remaining challengesen_US
dcterms.abstractRecent advancements in molecular biology, particularly regarding massively parallel sequencing technologies, have enabled scientists to gain more insight into the physiology of ticks. While there has been progress in identifying tick proteins and the pathways they are involved in, the specificities of tick-host interaction at the molecular level are not yet fully understood. Indeed, the development of effective commercial tick vaccines has been slower than expected. While omics studies have pointed to some potential vaccine immunogens, selecting suitable antigens for a multi-antigenic vaccine is very complex due to the participation of redundant molecules in biological pathways. The expansion of ticks and their pathogens into new territories and exposure to new hosts makes it necessary to evaluate vaccine efficacy in unusual and non-domestic host species. This situation makes ticks and tick-borne diseases an increasing threat to animal and human health globally, demanding an urgent availability of vaccines against multiple tick species and their pathogens. This review discusses the challenges and advancements in the search for universal tick vaccines, including promising new antigen candidates, and indicates future directions in this crucial research field.en_US
dcterms.accessRightsOpen Accessen_US
dcterms.audienceAcademicsen_US
dcterms.audienceScientistsen_US
dcterms.available2023-06-19en_US
dcterms.bibliographicCitationParizi, L.F., Githaka, N.W., Logullo, C., Zhou, J., Onuma, M., Termignoni, C. and Silva Vaz, I. da. 2023. Universal tick vaccines: Candidates and remaining challenges. Animals 13(12): 2031.en_US
dcterms.extent2031en_US
dcterms.issued2023-06-19en_US
dcterms.languageenen_US
dcterms.licenseCC-BY-4.0en_US
dcterms.publisherMDPIen_US
dcterms.subjectvaccinesen_US
dcterms.typeJournal Articleen_US

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