Universal tick vaccines: Candidates and remaining challenges

Simple item page
cg.authorship.typesCGIAR and developing country instituteen
cg.authorship.typesCGIAR and advanced research instituteen
cg.contributor.affiliationUniversidade Federal do Rio Grande do Sulen
cg.contributor.affiliationInternational Livestock Research Instituteen
cg.contributor.affiliationUniversidade Federal do Rio de Janeiroen
cg.contributor.affiliationChinese Academy of Agricultural Sciencesen
cg.contributor.affiliationHokkaido Universityen
cg.contributor.donorConselho Nacional de Desenvolvimento Científico e Tecnológicoen
cg.contributor.donorCoordenação de Aperfeiçoamento de Pessoal de Nível Superior, Brazilen
cg.contributor.donorFundação de Amparo à Pesquisa do Estado do Rio Grande do Sul, Brazilen
cg.creator.identifierNaftaly Githaka: 0000-0003-4530-7164
cg.howPublishedFormally Publisheden
cg.identifier.doihttps://doi.org/10.3390/ani13122031en
cg.isijournalISI Journalen
cg.issn2076-2615en
cg.issue12en
cg.journalAnimalsen
cg.reviewStatusPeer Reviewen
cg.subject.ilriVACCINESen
cg.subject.impactAreaNutrition, health and food security
cg.subject.sdgSDG 2 - Zero hungeren
cg.volume13en
dc.contributor.authorParizi, L.F.en
dc.contributor.authorGithaka, Naftaly W.en
dc.contributor.authorLogullo, C.en
dc.contributor.authorZhou, J.en
dc.contributor.authorOnuma, M.en
dc.contributor.authorTermignoni, C.en
dc.contributor.authorSilva Vaz, I. daen
dc.date.accessioned2023-06-26T08:58:53Zen
dc.date.available2023-06-26T08:58:53Zen
dc.identifier.urihttps://hdl.handle.net/10568/130866
dc.titleUniversal tick vaccines: Candidates and remaining challengesen
dcterms.abstractRecent advancements in molecular biology, particularly regarding massively parallel sequencing technologies, have enabled scientists to gain more insight into the physiology of ticks. While there has been progress in identifying tick proteins and the pathways they are involved in, the specificities of tick-host interaction at the molecular level are not yet fully understood. Indeed, the development of effective commercial tick vaccines has been slower than expected. While omics studies have pointed to some potential vaccine immunogens, selecting suitable antigens for a multi-antigenic vaccine is very complex due to the participation of redundant molecules in biological pathways. The expansion of ticks and their pathogens into new territories and exposure to new hosts makes it necessary to evaluate vaccine efficacy in unusual and non-domestic host species. This situation makes ticks and tick-borne diseases an increasing threat to animal and human health globally, demanding an urgent availability of vaccines against multiple tick species and their pathogens. This review discusses the challenges and advancements in the search for universal tick vaccines, including promising new antigen candidates, and indicates future directions in this crucial research field.en
dcterms.accessRightsOpen Access
dcterms.audienceAcademicsen
dcterms.audienceScientistsen
dcterms.available2023-06-19
dcterms.bibliographicCitationParizi, L.F., Githaka, N.W., Logullo, C., Zhou, J., Onuma, M., Termignoni, C. and Silva Vaz, I. da. 2023. Universal tick vaccines: Candidates and remaining challenges. Animals 13(12): 2031.en
dcterms.extent2031en
dcterms.issued2023-06-19
dcterms.languageen
dcterms.licenseCC-BY-4.0
dcterms.publisherMDPIen
dcterms.subjectvaccinesen
dcterms.typeJournal Article

Files

License bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.75 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

ILRI articles in journals
ILRI animal and human health program outputs (2017–2024)
ILRI Tick unit