High prevalence of Plasmodium malariae and Plasmodium ovale in co-infections with Plasmodium falciparum in asymptomatic malaria parasite carriers in southwestern Nigeria

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cg.authorship.typesCGIAR and developing country instituteen_US
cg.authorship.typesCGIAR and advanced research instituteen_US
cg.contributor.affiliationNagasaki Universityen_US
cg.contributor.affiliationDiana Princess of Wales Hospitalen_US
cg.contributor.affiliationNational Institutes of Healthen_US
cg.contributor.affiliationUniversity of New South Walesen_US
cg.contributor.affiliationInternational Livestock Research Instituteen_US
cg.contributor.affiliationKumamoto Universityen_US
cg.contributor.affiliationMoniya General Hospitalen_US
cg.contributor.affiliationUniversity of Ibadanen_US
cg.contributor.affiliationEhime Universityen_US
cg.coverage.countryNigeriaen_US
cg.coverage.iso3166-alpha2NGen_US
cg.coverage.regionAfricaen_US
cg.coverage.regionWestern Africaen_US
cg.creator.identifierHussein Abkallo: 0000-0002-5594-4418en_US
cg.howPublishedFormally Publisheden_US
cg.identifier.doihttps://doi.org/10.1016/j.ijpara.2021.06.003en_US
cg.isijournalISI Journalen_US
cg.issn0020-7519en_US
cg.issue1en_US
cg.journalInternational Journal for Parasitologyen_US
cg.reviewStatusPeer Reviewen_US
cg.subject.ilriHUMAN HEALTHen_US
cg.subject.impactAreaNutrition, health and food securityen_US
cg.subject.sdgSDG 3 - Good health and well-beingen_US
cg.volume52en_US
dc.contributor.authorAbdulraheem, M.A.en_US
dc.contributor.authorErnest, M.en_US
dc.contributor.authorUgwuanyi, I.en_US
dc.contributor.authorAbkallo, Hussein M.en_US
dc.contributor.authorNishikawa, S.en_US
dc.contributor.authorAdeleke, M.en_US
dc.contributor.authorOrimadegun, A.E.en_US
dc.contributor.authorCulleton, R.en_US
dc.date.accessioned2021-08-16T10:44:12Zen_US
dc.date.available2021-08-16T10:44:12Zen_US
dc.identifier.urihttps://hdl.handle.net/10568/114647en_US
dc.titleHigh prevalence of Plasmodium malariae and Plasmodium ovale in co-infections with Plasmodium falciparum in asymptomatic malaria parasite carriers in southwestern Nigeriaen_US
dcterms.abstractAsymptomatic malaria parasite carriers do not seek anti-malarial treatment and may constitute a silent infectious reservoir. In order to assess the level of asymptomatic and symptomatic carriage amongst adolescents in a highly endemic area, and to identify the risk factors associated with such carriage, we conducted a cross-sectional survey of 1032 adolescents (ages 10-19 years) from eight schools located in Ibadan, southwestern Nigeria in 2016. Blood films and blood spot filter paper samples were prepared for microscopy and DNA analysis. The prevalence of asymptomatic malaria was determined using microscopy, rapid diagnostic tests (RDTs) and PCR for 658 randomly selected samples. Of these, we found that 80% of asymptomatic schoolchildren were positive for malaria parasites by PCR, compared with 47% and 9%, determined by RDT and microscopy, respectively. Malaria parasite species typing was performed using PCR targeting the mitochondrial CoxIII gene, and revealed high rates of carriage of Plasmodium malariae (53%) and Plasmodium ovale (24%). Most asymptomatic infections were co-infections of two or more species (62%), with Plasmodium falciparum + P. malariae the most common (35%), followed by P. falciparum + P. malariae + P. ovale (21%) and P. falciparum + P. ovale (6%). Single infections of P. falciparum, P. malariae and P. ovale accounted for 24%, 10% and 4% of all asymptomatic infections, respectively. To compare the species composition of asymptomatic and symptomatic infections, further sample collection was carried out in 2017 at one of the previously sampled schools, and at a nearby hospital. Whilst the species composition of the asymptomatic infections was similar to that observed in 2016, the symptomatic infections were markedly different, with single infections of P. falciparum observed in 91% of patients, P. falciparum + P. malariae in 5% and P. falciparum + P. ovale in 4%.en_US
dcterms.accessRightsLimited Accessen_US
dcterms.audienceScientistsen_US
dcterms.audienceAcademicsen_US
dcterms.bibliographicCitationAbdulraheem, M.A., Ernest, M., Ugwuanyi, I., Abkallo, H.M., Nishikawa, S., Adeleke, M., Orimadegun, A.E. and Culleton, R. 2022. High prevalence of Plasmodium malariae and Plasmodium ovale in co-infections with Plasmodium falciparum in asymptomatic malaria parasite carriers in southwestern Nigeria. International Journal for Parasitology 52(1): 23–33.en_US
dcterms.extentp. 23-33en_US
dcterms.issued2022-01en_US
dcterms.languageenen_US
dcterms.licenseCopyrighted; all rights reserveden_US
dcterms.publisherElsevieren_US
dcterms.subjecthealthen_US
dcterms.subjectmalariaen_US
dcterms.subjectinfectious diseasesen_US
dcterms.subjectparasitologyen_US
dcterms.typeJournal Articleen_US

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