Genomic epidemiology of Rift Valley fever virus involved in the 2018 and 2022 outbreaks in livestock in Rwanda

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cg.authorship.typesCGIAR and developing country instituteen_US
cg.authorship.typesCGIAR and advanced research instituteen_US
cg.contributor.affiliationSokoine University of Agricultureen_US
cg.contributor.affiliationRwanda Inspectorate, Competition and Consumer Protection Authorityen_US
cg.contributor.affiliationVirginia Polytechnic Institute and State Universityen_US
cg.contributor.affiliationInternational Livestock Research Instituteen_US
cg.contributor.affiliationRwanda Agriculture and Animal Resources Development Boarden_US
cg.contributor.affiliationRwanda Biomedical Centeren_US
cg.contributor.donorFederal Ministry for Economic Cooperation and Development, Germanyen_US
cg.contributor.donorRegional Scholarship and Innovation Fund of the African Partnership for Skills in Applied Sciences, Engineering, and Technologyen_US
cg.contributor.donorGlobal Health EDCTP3 Joint Undertakingen_US
cg.contributor.donorBill & Melinda Gates Foundationen_US
cg.contributor.donorGovernment of Rwandaen_US
cg.coverage.countryRwandaen_US
cg.coverage.iso3166-alpha2RWen_US
cg.coverage.regionAfricaen_US
cg.coverage.regionEastern Africaen_US
cg.creator.identifierJohn Juma: 0000-0002-1481-5337en_US
cg.creator.identifierKristina Roesel: 0000-0002-2553-1129en_US
cg.creator.identifierBernard Bett: 0000-0001-9376-2941en_US
cg.creator.identifierSamuel O. Oyola: 0000-0002-6425-7345en_US
cg.howPublishedFormally Publisheden_US
cg.identifier.doihttps://doi.org/10.3390/v16071148en_US
cg.isijournalISI Journalen_US
cg.issn1999-4915en_US
cg.issue7en_US
cg.journalVirusesen_US
cg.reviewStatusPeer Reviewen_US
cg.subject.actionAreaResilient Agrifood Systemsen_US
cg.subject.ilriLIVESTOCKen_US
cg.subject.ilriRVFen_US
cg.subject.impactAreaNutrition, health and food securityen_US
cg.subject.impactPlatformNutrition, Health and Food Securityen_US
cg.subject.sdgSDG 2 - Zero hungeren_US
cg.volume16en_US
dc.contributor.authorNsengimana, I.en_US
dc.contributor.authorJuma, Johnen_US
dc.contributor.authorRoesel, Kristinaen_US
dc.contributor.authorGasana, M.N.en_US
dc.contributor.authorNdayisenga, F.en_US
dc.contributor.authorMuvunyi, C.M.en_US
dc.contributor.authorHakizimana, E.en_US
dc.contributor.authorHakizimana, J.N.en_US
dc.contributor.authorEastwood, G.en_US
dc.contributor.authorChengula, A.A.en_US
dc.contributor.authorBett, Bernard K.en_US
dc.contributor.authorKasanga, C.J.en_US
dc.contributor.authorOyola, Samuel O.en_US
dc.date.accessioned2024-07-19T09:45:12Zen_US
dc.date.available2024-07-19T09:45:12Zen_US
dc.identifier.urihttps://hdl.handle.net/10568/149156en_US
dc.titleGenomic epidemiology of Rift Valley fever virus involved in the 2018 and 2022 outbreaks in livestock in Rwandaen_US
dcterms.abstractRift Valley fever (RVF), a mosquito-borne transboundary zoonosis, was first confirmed in Rwanda’s livestock in 2012 and since then sporadic cases have been reported almost every year. In 2018, the country experienced its first large outbreak, which was followed by a second one in 2022. To determine the circulating virus lineages and their ancestral origin, two genome sequences from the 2018 outbreak, and thirty-six, forty-one, and thirty-eight sequences of small (S), medium (M), and large (L) genome segments, respectively, from the 2022 outbreak were generated. All of the samples from the 2022 outbreak were collected from slaughterhouses. Both maximum likelihood and Bayesian-based phylogenetic analyses were performed. The findings showed that RVF viruses belonging to a single lineage, C, were circulating during the two outbreaks, and shared a recent common ancestor with RVF viruses isolated in Uganda between 2016 and 2019, and were also linked to the 2006/2007 largest East Africa RVF outbreak reported in Kenya, Tanzania, and Somalia. Alongside the wild-type viruses, genetic evidence of the RVFV Clone 13 vaccine strain was found in slaughterhouse animals, demonstrating a possible occupational risk of exposure with unknown outcome for people working in meat-related industry. These results provide additional evidence of the ongoing wide spread of RVFV lineage C in Africa and emphasize the need for an effective national and international One Health-based collaborative approach in responding to RVF emergencies.en_US
dcterms.accessRightsOpen Accessen_US
dcterms.audienceAcademicsen_US
dcterms.audienceScientistsen_US
dcterms.available2024-07-17en_US
dcterms.bibliographicCitationNsengimana, I., Juma, J., Roesel, K., Gasana, M.N., Ndayisenga, F., Muvunyi, C.M., Hakizimana, E., Hakizimana, J.N., Eastwood, G., Chengula, A.A., Bett, B., Kasanga, C.J. and Oyola, S.O. 2024. Genomic epidemiology of Rift Valley fever virus involved in the 2018 and 2022 outbreaks in livestock in Rwanda. Viruses 16(7): 1148.en_US
dcterms.extent1148en_US
dcterms.issued2024-07-17en_US
dcterms.languageenen_US
dcterms.licenseCC-BY-4.0en_US
dcterms.publisherMDPIen_US
dcterms.subjectgenomicsen_US
dcterms.subjectlivestocken_US
dcterms.subjectrift valley feveren_US
dcterms.typeJournal Articleen_US

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