Causes and consequences of child growth faltering in low-resource settings

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cg.authorship.typesCGIAR single centreen_US
cg.authorship.typesCGIAR and advanced research instituteen_US
cg.contributor.affiliationInternational Food Policy Research Instituteen_US
cg.contributor.affiliationUniversity of California, Berkeleyen_US
cg.contributor.affiliationStanford Universityen_US
cg.contributor.affiliationChan Zuckerberg Biohuben_US
cg.contributor.affiliationDVPL Tech, Dubaien_US
cg.contributor.affiliationHafen Consultingen_US
cg.contributor.affiliationCytelen_US
cg.contributor.affiliationBill & Melinda Gates Foundationen_US
cg.contributor.affiliationUniversity of California, Davisen_US
cg.contributor.affiliationJohns Hopkins Bloomberg School of Public Healthen_US
cg.contributor.affiliationUniversity of California, San Franciscoen_US
cg.contributor.affiliationGhent Universityen_US
cg.contributor.affiliationUniversity of North Carolina at Chapel Hillen_US
cg.contributor.affiliationInternational Centre for Diarrhoeal Disease Researchen_US
cg.contributor.affiliationAga Khan Universityen_US
cg.contributor.affiliationJohns Hopkins Bangladeshen_US
cg.contributor.affiliationTampere University and Tampere University Hospitalen_US
cg.contributor.affiliationWorld Health Organizationen_US
cg.contributor.affiliationFundação Oswaldo Cruzen_US
cg.contributor.affiliationUnited Nations Children's Funden_US
cg.contributor.affiliationUniversity of Vendaen_US
cg.contributor.affiliationIndian Institute of Technologyen_US
cg.contributor.affiliationSociety for Applied Studiesen_US
cg.contributor.affiliationSunder Lal Jain Hospitalen_US
cg.contributor.affiliationArmed Forces Research Institute of Medical Sciencesen_US
cg.contributor.affiliationUniversity of San Carlosen_US
cg.contributor.affiliationUniversity of Leedsen_US
cg.contributor.affiliationUniversity of California, Los Angelesen_US
cg.contributor.affiliationBoston Children's Hospitalen_US
cg.contributor.affiliationUniversity of Southamptonen_US
cg.contributor.affiliationHarvard T.H. Chan School of Public Healthen_US
cg.contributor.affiliationFederal University of Cearáen_US
cg.contributor.affiliationUniversity of Virginiaen_US
cg.contributor.affiliationUniversity of New Mexico Health Sciences Centeren_US
cg.contributor.affiliationChristian Medical Collegeen_US
cg.contributor.affiliationTranslational Health Science and Technology Instituteen_US
cg.contributor.affiliationMcGill Universityen_US
cg.contributor.affiliationUniversity of Malawien_US
cg.contributor.affiliationMother and Infant Research Activitiesen_US
cg.contributor.affiliationMuhimbili University School of Health and Allied Sciencesen_US
cg.contributor.affiliationEmory Universityen_US
cg.contributor.affiliationHaydom Lutheran Hospitalen_US
cg.contributor.affiliationKing's College Londonen_US
cg.contributor.affiliationLondon School of Hygiene and Tropical Medicineen_US
cg.contributor.affiliationZvitambo Institute for Maternal and Child Health Researchen_US
cg.contributor.affiliationAB PRISMAen_US
cg.contributor.affiliationInstitute of Nutrition of Central America and Panamaen_US
cg.contributor.affiliationSitaram Bhartia Institute of Science and Researchen_US
cg.contributor.affiliationUniversity College Londonen_US
cg.contributor.affiliationHealth Research and Development Forumen_US
cg.contributor.affiliationWalter Reed/AFRIMS Research Uniten_US
cg.contributor.affiliationUniversity of Bergenen_US
cg.contributor.affiliationTufts University School of Medicineen_US
cg.contributor.donorBill & Melinda Gates Foundationen_US
cg.contributor.donorNational Institute of Allergy and Infectious Diseasesen_US
cg.creator.identifierElodie Becquey: 0000-0002-8748-7637en_US
cg.howPublishedFormally Publisheden_US
cg.identifier.doihttps://doi.org/10.1038/s41586-023-06501-xen_US
cg.identifier.projectIFPRI - Nutrition, Diets, and Health Uniten_US
cg.identifier.publicationRankA Plusen_US
cg.isijournalISI Journalen_US
cg.issn0028-0836en_US
cg.issn1476-4687en_US
cg.issue7979en_US
cg.journalNatureen_US
cg.reviewStatusPeer Reviewen_US
cg.volume621en_US
dc.contributor.authorMertens, Andrewen_US
dc.contributor.authorBenjamin-Chung, Jadeen_US
dc.contributor.authorColford Jr, John Men_US
dc.contributor.authorCoyle, Jeremyen_US
dc.contributor.authorvan der Laan, Marken_US
dc.contributor.authorHubbard, J. Alan Een_US
dc.contributor.authorRosete, Sonalien_US
dc.contributor.authorMalenica, Ivanaen_US
dc.contributor.authorHejazi, Nimaen_US
dc.contributor.authorSofrygin, Olegen_US
dc.contributor.authorCai, Wilsonen_US
dc.contributor.authorLi, Haodongen_US
dc.contributor.authorNguyen, Annaen_US
dc.contributor.authorPokpongkiat, Nolan Nen_US
dc.contributor.authorDjajadi, Stephanieen_US
dc.contributor.authorSeth, Anmolen_US
dc.contributor.authorJung, Estheren_US
dc.contributor.authorChung, Esther Oen_US
dc.contributor.authorJilek, Wendyen_US
dc.contributor.authorSubramoney, Vishaken_US
dc.contributor.authorHafen, Ryanen_US
dc.contributor.authorHäggström, Jonasen_US
dc.contributor.authorNorman, Theaen_US
dc.contributor.authorBrown, Kenneth Hen_US
dc.contributor.authorThe Ki Child Growth Consortiumen_US
dc.date.accessioned2024-02-14T17:12:15Zen_US
dc.date.available2024-02-14T17:12:15Zen_US
dc.identifier.urihttps://hdl.handle.net/10568/139385en_US
dc.titleCauses and consequences of child growth faltering in low-resource settingsen_US
dcterms.abstractGrowth faltering in children (low length for age or low weight for length) during the first 1,000 days of life (from conception to 2 years of age) influences short-term and long-term health and survival1,2. Interventions such as nutritional supplementation during pregnancy and the postnatal period could help prevent growth faltering, but programmatic action has been insufficient to eliminate the high burden of stunting and wasting in low- and middle-income countries. Identification of age windows and population subgroups on which to focus will benefit future preventive efforts. Here we use a population intervention effects analysis of 33 longitudinal cohorts (83,671 children, 662,763 measurements) and 30 separate exposures to show that improving maternal anthropometry and child condition at birth accounted for population increases in length-for-age z-scores of up to 0.40 and weight-for-length z-scores of up to 0.15 by 24 months of age. Boys had consistently higher risk of all forms of growth faltering than girls. Early postnatal growth faltering predisposed children to subsequent and persistent growth faltering. Children with multiple growth deficits exhibited higher mortality rates from birth to 2 years of age than children without growth deficits (hazard ratios 1.9 to 8.7). The importance of prenatal causes and severe consequences for children who experienced early growth faltering support a focus on pre-conception and pregnancy as a key opportunity for new preventive interventions.en_US
dcterms.accessRightsOpen Accessen_US
dcterms.audienceAcademicsen_US
dcterms.available2023-09-13en_US
dcterms.bibliographicCitationMertens, Andrew; Benjamin-Chung, Jade; Colford Jr, John M.; Coyle, Jeremy; van der Laan, Mark; Hubbard, J. Alan E.; et al. 2023. Causes and consequences of child growth faltering in low-resource settings. Nature 621: 568-576. https://doi.org/10.1038/s41586-023-06501-xen_US
dcterms.extent568-576en_US
dcterms.issued2023-09-13en_US
dcterms.languageenen_US
dcterms.licenseCC-BY-4.0en_US
dcterms.publisherSpringeren_US
dcterms.replaceshttps://ebrary.ifpri.org/digital/collection/p15738coll5/id/9027en_US
dcterms.subjectchild growthen_US
dcterms.subjecthealthen_US
dcterms.subjectstuntingen_US
dcterms.subjectanthropometryen_US
dcterms.typeJournal Articleen_US

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