Modeling relationships between iron status, behavior, and brain electrophysiology: Evidence from a randomized study involving a biofortified grain in Indian adolescents

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cg.authorship.typesCGIAR single centreen
cg.contributor.affiliationInternational Food Policy Research Instituteen
cg.contributor.crpAgriculture for Nutrition and Health
cg.coverage.countryIndia
cg.coverage.iso3166-alpha2IN
cg.coverage.regionSouthern Asia
cg.coverage.regionAsia
cg.creator.identifierSamuel Scott: 0000-0002-5564-0510
cg.creator.identifierErick Boy: 0000-0002-0271-1725
cg.identifier.doihttps://doi.org/10.1186/s12889-022-13612-zen
cg.identifier.projectIFPRI - HarvestPlus
cg.identifier.projectIFPRI - Poverty, Health, and Nutrition Division
cg.identifier.publicationRankB
cg.isijournalISI Journalen
cg.issn1471-2458en
cg.issue1en
cg.journalBMC Public Healthen
cg.reviewStatusPeer Reviewen
cg.volume22en
dc.contributor.authorWenger, Michael J.en
dc.contributor.authorMurray-Kolb, Laura E.en
dc.contributor.authorScott, Samuel P.en
dc.contributor.authorBoy, Ericken
dc.contributor.authorHaas, Jere D.en
dc.date.accessioned2024-04-12T13:37:34Zen
dc.date.available2024-04-12T13:37:34Zen
dc.identifier.urihttps://hdl.handle.net/10568/141262
dc.titleModeling relationships between iron status, behavior, and brain electrophysiology: Evidence from a randomized study involving a biofortified grain in Indian adolescentsen
dcterms.abstractBackground: Iron deficiency (ID) and iron deficiency anemia (IDA) are highly-prevalent nutrient deficiencies and have been shown to have a range of negative effects on cognition and brain function. Human intervention studies including measures at three levels—blood, brain, and behavior—are rare and our objective was to model the relationships among measures at these three levels in school-going Indian adolescents. Methods: Male and female adolescents in rural India were screened for ID/IDA. Subjects consumed 2 meals/day for 6 months; half were randomly assigned to consume meals made from a standard grain (pearl millet) and half consumed meals made from an iron biofortified pearl millet (BPM). Prior to and then at the conclusion of the feeding trial, they completed a set of cognitive tests with concurrent electroencephalography (EEG). Results: Overall, serum ferritin (sFt) levels improved over the course of the study. Ten of 21 possible measures of cognition showed improvements from baseline (BL) to endline (EL) that were larger for those consuming BPM than for those consuming the comparison pearl millet (CPM). Critically, the best model for the relationship between change in iron status and change in cognition had change in brain measures as a mediating factor, with both change in serum ferritin as a primary predictor and change in hemoglobin as a moderator. Conclusions: A dietary intervention involving a biofortified staple grain was shown to be efficacious in improving blood iron biomarkers, behavioral measures of cognition, and EEG measures of brain function. Modeling the relationships among these variables strongly suggests multiple mechanisms by which blood iron level affects brain function and cognition.en
dcterms.accessRightsOpen Access
dcterms.bibliographicCitationWenger, Michael J.; Murray-Kolb, Laura E.; Scott, Samuel; Boy, Erick; and Haas, Jere D. 2022. Modeling relationships between iron status, behavior, and brain electrophysiology: Evidence from a randomized study involving a biofortified grain in Indian adolescents. BMC Public Health 22: 1299. https://doi.org/10.1186/s12889-022-13612-zen
dcterms.issued2022-07-06
dcterms.languageen
dcterms.licenseCC-BY-4.0
dcterms.publisherSpringer Nature Limiteden
dcterms.relationhttps://doi.org/10.3945/jn.117.255356en
dcterms.relationhttp://doi.org/10.1186/s12889-022-13897-0en
dcterms.replaceshttps://ebrary.ifpri.org/digital/collection/p15738coll5/id/8305en
dcterms.subjectelectroencephalographyen
dcterms.subjectanaemiaen
dcterms.subjectmemoryen
dcterms.subjectpearl milleten
dcterms.subjectcognitionen
dcterms.subjectadolescentsen
dcterms.subjectbiofortificationen
dcterms.subjecttrace element deficienciesen
dcterms.subjectnutrient deficienciesen
dcterms.subjectbrainen
dcterms.subjectblooden
dcterms.subjectironen
dcterms.subjectbehaviouren
dcterms.typeJournal Article

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