Transcriptome profiles of organ tissues from pigs experimentally infected with African swine fever virus in early phase of infection

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cg.authorship.typesCGIAR and developing country instituteen
cg.contributor.affiliationRural Development Administration, Republic of Koreaen
cg.contributor.affiliationJeonbuk National Universityen
cg.contributor.affiliationNational Institute of Veterinary Research, Vietnamen
cg.contributor.affiliationTNT Research Co. Ltd., Republic of Koreaen
cg.contributor.affiliationInternational Livestock Research Instituteen
cg.contributor.affiliationChung Nam National Universityen
cg.contributor.donorMinistry of Agriculture, Food and Rural Affairs, Republic of Koreaen
cg.coverage.countryVietnam
cg.coverage.iso3166-alpha2VN
cg.coverage.regionAsia
cg.coverage.regionSouth-eastern Asia
cg.creator.identifierHu Suk Lee: 0000-0002-8731-9836
cg.howPublishedFormally Publisheden
cg.identifier.doihttps://doi.org/10.1080/22221751.2024.2366406en
cg.isijournalISI Journalen
cg.issn2222-1751en
cg.issue1en
cg.journalEmerging Microbes & Infectionsen
cg.reviewStatusPeer Reviewen
cg.subject.actionAreaResilient Agrifood Systems
cg.subject.ilriASFen
cg.subject.ilriPIGSen
cg.subject.impactAreaNutrition, health and food security
cg.subject.impactPlatformNutrition, Health and Food Security
cg.subject.sdgSDG 2 - Zero hungeren
cg.volume13en
dc.contributor.authorSang-Ik Ohen
dc.contributor.authorSheet, S.en
dc.contributor.authorVuong Nghia Buien
dc.contributor.authorDuy Tung Daoen
dc.contributor.authorNgoc Anh Buien
dc.contributor.authorTae-Hun Kimen
dc.contributor.authorCha, J.en
dc.contributor.authorMi-Rim Parken
dc.contributor.authorTai-Young Huren
dc.contributor.authorYoung-Hun Jungen
dc.contributor.authorKim, B.en
dc.contributor.authorHu Suk Leeen
dc.contributor.authorCho, A.en
dc.contributor.authorLim, D.en
dc.date.accessioned2024-06-11T04:00:36Zen
dc.date.available2024-06-11T04:00:36Zen
dc.identifier.urihttps://hdl.handle.net/10568/145121
dc.titleTranscriptome profiles of organ tissues from pigs experimentally infected with African swine fever virus in early phase of infectionen
dcterms.abstractAfrican swine fever, caused by African swine fever virus (ASFV), is a highly contagious and fatal disease that poses a significant threat to the global pig industry. The limited information on ASFV pathogenesis and ASFV–host interactions has recently prompted numerous transcriptomic studies. However, most of these studies have focused on elucidating the transcriptome profiles of ASFV-infected porcine alveolar macrophages in vitro. Here, we analyzed dynamic transcriptional patterns in vivo in nine organ tissues (spleen, submandibular lymph node, mesenteric lymph node, inguinal lymph node, tonsils, lungs, liver, kidneys, and heart) obtained from pigs in the early stages of ASFV infection (1 and 3 d after viremia). We observed rapid spread of ASFV to the spleen after viremia, followed by broad transmission to the liver and lungs and subsequently, the submandibular and inguinal lymph nodes. Profound variations in gene expression patterns were observed across all organs and at all time-points, providing an understanding of the distinct defence strategies employed by each organ against ASFV infection. All ASFV-infected organs exhibited a collaborative response, activating immune-associated genes such as S100A8, thereby triggering a pro-inflammatory cytokine storm and interferon activation. Functional analysis suggested that ASFV exploits the PI3K-Akt signalling pathway to evade the host immune system. Overall, our findings provide leads into the mechanisms underlying pathogenesis and host immune responses in different organs during the early stages of infection, which can guide further explorations, aid the development of efficacious antiviral strategies against ASFV, and identify valuable candidate gene targets for vaccine development.en
dcterms.accessRightsOpen Access
dcterms.audienceAcademicsen
dcterms.audienceScientistsen
dcterms.available2024-06-26
dcterms.bibliographicCitationSang-Ik Oh, Sheet, S., Vuong Nghia Bui, Duy Tung Dao, Ngoc Anh Bui, Tae-Hun Kim, Cha, J., Mi-Rim Park, Tai-Young Hur, Young-Hun Jung, Kim, B., Hu Suk Lee, Cho, A. and Lim, D. 2024. Transcriptome profiles of organ tissues from pigs experimentally infected with African swine fever virus in early phase of infection. Emerging Microbes & Infections 13(1): 2366406.en
dcterms.extent2366406en
dcterms.issued2024-06-26
dcterms.languageen
dcterms.licenseCC-BY-4.0
dcterms.publisherInforma UK Limiteden
dcterms.subjectafrican swine feveren
dcterms.subjectswineen
dcterms.typeJournal Article

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