Molecular detection and typing of pathogenic Leptospira species from livestock and small mammals in Uganda

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cg.authorship.typesCGIAR and developing country instituteen
cg.authorship.typesCGIAR and advanced research instituteen
cg.contributor.affiliationInternational Livestock Research Instituteen
cg.contributor.affiliationUniversity of Bernen
cg.contributor.affiliationMakerere Universityen
cg.contributor.affiliationFederal Institute for Risk Assessment, Germanyen
cg.contributor.affiliationNational Livestock Resources Research Institute, Ugandaen
cg.contributor.affiliationMinistry of Agriculture, Animal Industry and Fisheries, Ugandaen
cg.contributor.affiliationUniversity of Hohenheimen
cg.contributor.crpAgriculture for Nutrition and Health
cg.contributor.crpLivestock
cg.contributor.donorFederal Ministry for Economic Cooperation and Development, Germanyen
cg.contributor.donorCGIAR Trust Funden
cg.contributor.initiativeOne Health
cg.coverage.countryUganda
cg.coverage.iso3166-alpha2UG
cg.coverage.regionAfrica
cg.coverage.regionEastern Africa
cg.creator.identifierLordrick Alinaitwe: 0000-0002-5432-6407en
cg.creator.identifierVelma Kivali: 0000-0003-0797-4484en
cg.creator.identifierJames Bugeza: 0000-0002-8124-2807en
cg.creator.identifierKristina Roesel: 0000-0002-2553-1129en
cg.creator.identifierElizabeth Cook: 0000-0001-6081-8363en
cg.howPublishedFormally Publisheden
cg.identifier.doihttps://doi.org/10.1017/s0950268825000044en
cg.isijournalISI Journalen
cg.issn0950-2688en
cg.journalEpidemiology and Infectionen
cg.reviewStatusPeer Reviewen
cg.subject.actionAreaResilient Agrifood Systems
cg.subject.ilriCATTLEen
cg.subject.ilriEPIDEMIOLOGYen
cg.subject.ilriGOATSen
cg.subject.ilriLIVESTOCKen
cg.subject.ilriPIGSen
cg.subject.ilriSMALL RUMINANTSen
cg.subject.ilriZOONOTIC DISEASESen
cg.subject.impactAreaNutrition, health and food security
cg.subject.sdgSDG 2 - Zero hungeren
cg.volume153en
dc.contributor.authorAlinaitwe, Lordricken
dc.contributor.authorWainaina, Martinen
dc.contributor.authorDürr, S.en
dc.contributor.authorKankya, C.en
dc.contributor.authorKivali, Velmaen
dc.contributor.authorBugeza, Jamesen
dc.contributor.authorAturinda, C.J.en
dc.contributor.authorLubega, A.en
dc.contributor.authorMayer-Scholl, A.en
dc.contributor.authorHoona, J.J.en
dc.contributor.authorBahn, P.en
dc.contributor.authorHammerl, J.A.en
dc.contributor.authorRoesel, Kristinaen
dc.contributor.authorCook, Elizabeth A.J.en
dc.contributor.authorRichter, M.H.en
dc.date.accessioned2025-04-02T05:23:03Zen
dc.date.available2025-04-02T05:23:03Zen
dc.identifier.urihttps://hdl.handle.net/10568/173963
dc.titleMolecular detection and typing of pathogenic Leptospira species from livestock and small mammals in Ugandaen
dcterms.abstract<i>Leptospira</i> are bacteria that cause leptospirosis in both humans and animals. Human <i>Leptospira</i> infections in Uganda are suspected to arise from animal–human interactions. From a nationwide survey to determine Leptospira prevalence and circulating sequence types in Uganda, we tested 2030 livestock kidney samples, and 117 small mammals (rodents and shrews) using real-time PCR targeting the lipL32 gene. Pathogenic <i>Leptospira</i> species were detected in 45 livestock samples but not in the small mammals. The prevalence was 6.12% in sheep, 4.25% in cattle, 2.08% in goats, and 0.46% in pigs. Sequence typing revealed that <i>Leptospira borgpetersenii</i>, <i>Leptospira kirschneri</i>, and <i>Leptospira interrogans</i> are widespread across Uganda, with 13 novel sequence types identified. These findings enhance the East African MLST database and support the hypothesis that domesticated animals may be a source of human leptospirosis in Uganda, highlighting the need for increased awareness among those in close contact with livestock.en
dcterms.accessRightsOpen Access
dcterms.audienceAcademicsen
dcterms.audienceScientistsen
dcterms.available2025-01-22en
dcterms.bibliographicCitationAlinaitwe, L., Wainaina, M., Dürr, S., Kankya, C., Kivali, V., Bugeza, J., Aturinda, C.J., Lubega, A., Mayer-Scholl, A., Hoona, J.J., Bahn, P., Hammerl, J.A., Roesel, K., Cook, E.A.J. and Richter, M.H. 2025. Molecular detection and typing of pathogenic <i>Leptospira</i> species from livestock and small mammals in Uganda. Epidemiology and Infection 153: e50.en
dcterms.extente50en
dcterms.issued2025-01-22en
dcterms.languageen
dcterms.licenseCC-BY-4.0
dcterms.publisherCambridge University Pressen
dcterms.subjectcattleen
dcterms.subjectepidemiologyen
dcterms.subjectgoatsen
dcterms.subjectleptospiraen
dcterms.subjectlivestocken
dcterms.subjectsmall ruminantsen
dcterms.subjectswineen
dcterms.subjectzoonosesen
dcterms.typeJournal Article

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