Effects of aflatoxins and fumonisins, alone or in combination, on performance, health, and safety of food products of broiler chickens, and mitigation efficacy of bentonite and fumonisin esterase

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cg.authorship.typesCGIAR and developing country instituteen_US
cg.authorship.typesCGIAR and advanced research instituteen_US
cg.contributor.affiliationUniversity of Liègeen_US
cg.contributor.affiliationGhent Universityen_US
cg.contributor.affiliationChuka Universityen_US
cg.contributor.affiliationUniversity of Nairobien_US
cg.contributor.affiliationDSM - BIOMIN Research Centeren_US
cg.contributor.affiliationInternational Livestock Research Instituteen_US
cg.contributor.affiliationUppsala Universityen_US
cg.contributor.affiliationSwedish University of Agricultural Sciencesen_US
cg.contributor.donorMinistry of Education, Science and Technology, Kenyaen_US
cg.contributor.donorBelgian National Fund for Scientific Researchen_US
cg.contributor.donorBelgian Science Policy Officeen_US
cg.contributor.donorHarbro Ltd.en_US
cg.contributor.donorResearch Council of Norwayen_US
cg.contributor.donorNational Research Foundation, South Africaen_US
cg.contributor.donorBIOMIN Holding GmbHen_US
cg.coverage.regionAfricaen_US
cg.coverage.regionSub-Saharan Africaen_US
cg.creator.identifierJohanna Lindahl: 0000-0002-1175-0398en_US
cg.howPublishedFormally Publisheden_US
cg.identifier.doihttps://doi.org/10.1021/acs.jafc.3c01733en_US
cg.isijournalISI Journalen_US
cg.issn0021-8561en_US
cg.issue36en_US
cg.journalJournal of Agricultural and Food Chemistryen_US
cg.reviewStatusPeer Reviewen_US
cg.subject.ilriAFLATOXINSen_US
cg.subject.ilriCHICKENSen_US
cg.subject.ilriFEEDSen_US
cg.subject.ilriFOOD SAFETYen_US
cg.subject.ilriPOULTRYen_US
cg.subject.impactAreaNutrition, health and food securityen_US
cg.subject.sdgSDG 3 - Good health and well-beingen_US
cg.volume71en_US
dc.contributor.authorOchieng, P.E.en_US
dc.contributor.authorCroubels, S.en_US
dc.contributor.authorKemboi, D.en_US
dc.contributor.authorOkoth, S.en_US
dc.contributor.authorBaere, S. deen_US
dc.contributor.authorCavalier, E.en_US
dc.contributor.authorKang'ethe, Erastus K.en_US
dc.contributor.authorFaas, J.en_US
dc.contributor.authorDoupovec, B.en_US
dc.contributor.authorGathumbi, J.en_US
dc.contributor.authorDouny, C.en_US
dc.contributor.authorScippo, M.-L.en_US
dc.contributor.authorLindahl, Johanna F.en_US
dc.contributor.authorAntonissen, G.en_US
dc.date.accessioned2023-09-05T07:56:00Zen_US
dc.date.available2023-09-05T07:56:00Zen_US
dc.identifier.urihttps://hdl.handle.net/10568/131736en_US
dc.titleEffects of aflatoxins and fumonisins, alone or in combination, on performance, health, and safety of food products of broiler chickens, and mitigation efficacy of bentonite and fumonisin esteraseen_US
dcterms.abstractThe current study evaluated the effects of feeding diets contaminated with aflatoxin B1 (AFB1), fumonisins (FBs), or both on the performance and health of broiler chickens and the safety of their food products as well as the efficacy of bentonite and fumonisin esterase to mitigate the effects of these mycotoxins under conditions representative for sub-Saharan Africa (SSA). Four hundred one-day-old Cobb 500 broiler chickens were randomly assigned to 20 treatments with either a control diet, a diet with moderate AFB1 (60 μg/kg feed) or high AFB1 (220 μg/kg feed), or FBs (17,430 μg FB1+FB2/kg feed), alone or in combination, a diet containing AFB1 (either 60 or 220 μg/kg) and/or FBs (17,430 μg FB1+FB2/kg) and bentonite or fumonisin esterase or both, or a diet with bentonite or fumonisin esterase only. The experimental diets were given to the birds from day 1 to day 35 of age, and the effects of the different treatments on production performance were assessed by feed intake (FI), body weight gain (BWG), and feed conversion ratio (FCR). Possible health effects were evaluated through blood biochemistry, organ weights, mortality, liver gross pathological changes, and vaccine response. Residues of aflatoxins (AFB1, B2, G1, G2, M1 and M2) were determined in plasma, muscle, and liver tissues using validated UHPLC-MS/MS methods. The results obtained indicated that broiler chickens fed high AFB1 alone had poor FCR when compared to a diet with both high AFB1 and FBs (p = 0.0063). Serum total protein and albumin from birds fed FBs only or in combination with moderate or high AFB1 or detoxifiers increased when compared to the control (p < 0.05). Liver gross pathological changes were more pronounced in birds fed contaminated diets when compared to birds fed the control or diets supplemented with mycotoxin detoxifiers. The relative weight of the heart was significantly higher in birds fed high AFB1 and FBs when compared to the control or high AFB1 only diets (p < 0.05), indicating interactions between the mycotoxins. Inclusion of bentonite in AFB1-contaminated diets offered a protective effect on the change in weights of the liver, heart and spleen (p < 0.05). Residues of AFB1 were detected above the limit of quantification (max: 0.12 ± 0.03 μg/kg) in liver samples only, from birds fed a diet with high AFB1 only or with FBs or the detoxifiers. Supplementing bentonite into these AFB1-contaminated diets reduced the levels of the liver AFB1 residues by up to 50%. Bentonite or fumonisin esterase, alone, did not affect the performance and health of broiler chickens. Thus, at the doses tested, both detoxifiers were safe and efficient for use as valid means of counteracting the negative effects of AFB1 and FBs as well as transfer of AFB1 to food products (liver) of broiler chickens.en_US
dcterms.accessRightsLimited Accessen_US
dcterms.audienceAcademicsen_US
dcterms.audienceScientistsen_US
dcterms.available2023-09-01en_US
dcterms.bibliographicCitationOchieng, P.E., Croubels, S., Kemboi, D., Okoth, S., De Baere, S., Cavalier, E., Kang'ethe, E., Faas, J., Doupovec, B., Gathumbi, J., Douny, C., Scippo, M.-L., Lindahl, J.F. and Antonissen, G. 2023. Effects of aflatoxins and fumonisins, alone or in combination, on performance, health, and safety of food products of broiler chickens, and mitigation efficacy of bentonite and fumonisin esterase. Journal of Agricultural and Food Chemistry 71(36): 13462–13473.en_US
dcterms.extent13462–13473en_US
dcterms.issued2023-09-01en_US
dcterms.languageenen_US
dcterms.licenseCopyrighted; all rights reserveden_US
dcterms.publisherAmerican Chemical Societyen_US
dcterms.subjectaflatoxinsen_US
dcterms.subjectfood safetyen_US
dcterms.subjectfumonisinsen_US
dcterms.subjectbentoniteen_US
dcterms.subjectfeedsen_US
dcterms.subjectpoultryen_US
dcterms.subjectchickensen_US
dcterms.typeJournal Articleen_US

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