Study protocol to assess aflatoxin M1 health risks versus benefits of dairy consumption in Ethiopian children: An epidemiological trial and risk-benefit analysis

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cg.authorship.typesCGIAR and advanced research instituteen
cg.authorship.typesCGIAR single centreen
cg.contributor.affiliationMichigan State Universityen
cg.contributor.affiliationInternational Food Policy Research Instituteen
cg.contributor.affiliationEthiopian Public Health Instituteen
cg.contributor.donorBill & Melinda Gates Foundationen
cg.contributor.donorUnited States Agency for International Developmenten
cg.coverage.countryEthiopia
cg.coverage.iso3166-alpha2ET
cg.coverage.regionAfrica
cg.coverage.regionEastern Africa
cg.creator.identifierDEREK HEADEY: 0000-0003-2476-5131en
cg.creator.identifierKalle Hirvonen: 0000-0003-2057-1612en
cg.howPublishedFormally Publisheden
cg.identifier.doihttps://doi.org/10.1136/bmjopen-2024-084257en
cg.identifier.projectIFPRI - Development Strategies and Governance Uniten
cg.identifier.projectIFPRI - Feed the Futureen
cg.identifier.projectIFPRI - Poverty, Gender, and Inclusion Uniten
cg.identifier.publicationRankBen
cg.isijournalISI Journalen
cg.issn2044-6055en
cg.issue4en
cg.journalBMJ Openen
cg.reviewStatusPeer Reviewen
cg.volume14en
dc.contributor.authorWu, Feliciaen
dc.contributor.authorHeadey, Derek D.en
dc.contributor.authorHirvonen, Kalleen
dc.contributor.authorPokharel, Ashishen
dc.contributor.authorTessema, Masreshaen
dc.date.accessioned2024-05-08T16:41:26Zen
dc.date.available2024-05-08T16:41:26Zen
dc.identifier.urihttps://hdl.handle.net/10568/141774
dc.titleStudy protocol to assess aflatoxin M1 health risks versus benefits of dairy consumption in Ethiopian children: An epidemiological trial and risk-benefit analysisen
dcterms.abstractIntroduction In Sidama, Ethiopia, animal-source foods can be difficult to access. Milk has important nutrients for child growth, but carries the risk of aflatoxin M1 (AFM1) contamination. AFM1 is a metabolite of the mycotoxin aflatoxin B1 (AFB1) in dairy feed; cows secrete AFM1 in milk when their feed contains AFB1 produced by Aspergillus fungi in maize, nuts and oilseeds. It is unknown whether AFM1 compromises child growth and health. Methods and analysis This protocol paper describes our study in Sidama to determine the impact of milk consumption and AFM1 on child growth in the first 18 months of life. We will collect baseline and end-line data on dairy production, socioeconomic and nutritional factors of 1000 dairy-owning households with children ages 6–18 months at baseline; and gather samples of milk and dairy feed and child anthropometrics. We will conduct phone interviews every 6 months to ascertain changes in practices or child health. Dairy feed will be tested for AFB1; milk for AFM1, pathogens and nutrients. Controlling for herd size, socioeconomic, nutritional and behavioural factors, we will determine the association between child anthropometrics and milk consumption, as well as AFM1 exposure. We will examine whether AFM1 exposure affects child growth in the first 18 months of life, and weigh the benefits and risks of milk consumption. Ethics and dissemination The protocol is approved by the Institutional Review Boards of the Ethiopian Public Health Institute (EPHI-IRB-481–2022), Michigan State University (STUDY00007996) and International Food Policy Research Institute (DSGD-23–0102). Written informed consent will be obtained from all participants, who may withdraw from the study at any time. Confidentiality of collected data will be given high priority during each stage of data handling. The study’s findings will be disseminated through stakeholder workshops, local and international conferences, journal articles and technical reports.en
dcterms.accessRightsOpen Access
dcterms.audienceScientistsen
dcterms.available2024-04-28en
dcterms.bibliographicCitationWu, Felicia; Headey, Derek D.; Hirvonen, Kalle; Pokharel, Ashish; and Tessema, Masresha. 2024. Study protocol to assess aflatoxin M1 health risks versus benefits of dairy consumption in Ethiopian children: An epidemiological trial and risk-benefit analysis. BMJ Open 14(4): e084257. https://doi.org/10.1136/bmjopen-2024-084257en
dcterms.extente084257en
dcterms.issued2024-04-28en
dcterms.languageen
dcterms.licenseCC-BY-4.0
dcterms.publisherBMJen
dcterms.relationhttps://doi.org/10.1016/j.onehlt.2023.100672en
dcterms.subjectaflatoxin M1en
dcterms.subjectanimal source foodsen
dcterms.subjectepidemiologyen
dcterms.subjectmilken
dcterms.subjectrisk analysisen
dcterms.typeJournal Article

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