Impact of preconceptional micronutrient supplementation on maternal mental health during pregnancy and postpartum: Results from a randomized controlled trial in Vietnam

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cg.authorship.typesCGIAR single centreen
cg.contributor.crpAgriculture for Nutrition and Health
cg.coverage.countryVietnam
cg.coverage.iso3166-alpha2VN
cg.coverage.regionAsia
cg.coverage.regionSouth-eastern Asia
cg.creator.identifierPhuong H Nguyen: 0000-0003-3418-1674
cg.identifier.doihttps://doi.org/10.1186/s12905-017-0401-3en
cg.identifier.projectIFPRI - Poverty, Health, and Nutrition Division
cg.identifier.publicationRankNot ranked
cg.issn1472-6874en
cg.issue1en
cg.journalBMC Women's Healthen
cg.reviewStatusPeer Reviewen
cg.volume17en
dc.contributor.authorNguyen, Phuong Hongen
dc.contributor.authorDiGirolamo, Ann M.en
dc.contributor.authorGonzalez-Casanova, Inesen
dc.contributor.authorPham, Hoaen
dc.contributor.authorHao, Weien
dc.contributor.authorNguyen, Hieuen
dc.contributor.authorTruong, Truong V.en
dc.contributor.authorNguyen, Sonen
dc.contributor.authorHarding, Kimberly B.en
dc.contributor.authorReinhart, Gregory A.en
dc.contributor.authorMartorell, Reynaldoen
dc.contributor.authorRamakrishnan, Ushaen
dc.date.accessioned2024-06-21T09:23:20Zen
dc.date.available2024-06-21T09:23:20Zen
dc.identifier.urihttps://hdl.handle.net/10568/147805
dc.titleImpact of preconceptional micronutrient supplementation on maternal mental health during pregnancy and postpartum: Results from a randomized controlled trial in Vietnamen
dcterms.abstractBackground Micronutrient malnutrition has been associated with maternal depressive symptoms (MDS), but little is known about the effects of preconceptional micronutrient supplementation. This paper examined the effects of preconceptional micronutrient supplementation on MDS during pregnancy and postpartum. Methods We used data from a double-blind controlled trial (PRECONCEPT) in which 5011 Vietnamese women were randomized to receive weekly supplements containing either a) multiple micronutrients (MM) b) iron and folic acid (IFA) or c) folic acid (FA) until conception (n = 1813). Maternal mental health was assessed using the Center for Epidemiologic Studies Depression Scale (CES-D) at baseline (preconception), and the Edinburgh Postnatal Depression Scale (EPDS) during pregnancy and 3 months postpartum. Elevated MDS was defined as EPDS score ≥ 4. All group comparisons were done using ANOVA or chi-square tests of proportions intention to treat and per protocol analyses (women consumed supplements ≥26 weeks before conception). We also conducted stratified analyses by preconception CES-D scores, underweight, or anemia status using generalized linear models. Results Baseline CES-D scores were similar across treatment groups. The proportion of women experiencing elevated MDS was 11.3, 8.1 and 4.9% at first, second and third trimesters of pregnancy, respectively, and 3.6% at 3 mo postpartum. Mean EPDS scores at first (1.5 ± 2.7), second (1.1 ± 2.4), and third trimester of pregnancy (0.7 ± 2.0) and early postpartum (0.6 ± 1.8) were low and did not differ by treatment group. However, among women in the highest tertile of CES-D scores at preconception, mean EPDS scores in the first and second trimesters of pregnancy were lower in the MM and IFA groups compared to FA only (P < 0.05). Conclusions Weekly preconceptional micronutrient supplements containing iron did not improve depression measures relative to folic acid alone among all women, but may have benefitted women who were at risk for depression.en
dcterms.bibliographicCitationNguyen, Phuong H.; DiGirolamo, Ann M.; Gonzalez-Casanova, Ines; Pham, Hoa; Hao, Wei; Nguyen, Hieu; Truong, Truong V.; Nguyen, Son; Harding, Kimberly B.; Reinhart, Gregory A.; Martorell, Reynaldo; and Ramakrishnan, Usha. 2017. Impact of preconceptional micronutrient supplementation on maternal mental health during pregnancy and postpartum: results from a randomized controlled trial in Vietnam. BMC Women's Health 17 (44): https://doi.org/10.1186/s12905-017-0401-3en
dcterms.issued2017
dcterms.languageen
dcterms.publisherSpringer Science and Business Media LLCen
dcterms.replaceshttps://ebrary.ifpri.org/digital/collection/p15738coll5/id/5873en
dcterms.subjectmental healthen
dcterms.subjectrandomized controlled trialen
dcterms.subjectsupplementsen
dcterms.typeJournal Article

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