Stacking beneficial haplotypes from the Vavilov wheat collection to accelerate breeding for multiple disease resistance

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cg.contributor.affiliationUniversity of Queenslanden
cg.contributor.affiliationUniversity of Southern Queenslanden
cg.contributor.donorCGIAR Trust Funden
cg.contributor.donorGrains Research and Development Corporationen
cg.contributor.initiativeAccelerated Breeding
cg.contributor.initiativeBreeding Resources
cg.contributor.initiativeGenebanks
cg.contributor.initiativePlant Health
cg.coverage.countryMalawi
cg.coverage.iso3166-alpha2MW
cg.coverage.regionEastern Africa
cg.creator.identifierLee Hickey: 0000-0001-6909-7101en
cg.howPublishedFormally Publisheden
cg.identifier.doihttps://doi.org/10.1007/s00122-024-04784-wen
cg.isijournalISI Journalen
cg.issn1432-2242en
cg.journalTheoretical and Applied Geneticsen
cg.reviewStatusPeer Reviewen
cg.subject.actionAreaGenetic Innovation
cg.subject.impactAreaClimate adaptation and mitigation
dc.contributor.authorJingyang Tongen
dc.contributor.authorTarekegn, Zerihun T.en
dc.contributor.authorJambuthenne, Dilanien
dc.contributor.authorAlahmad, Samiren
dc.contributor.authorPeriyannan, Sambasivamen
dc.contributor.authorLee T. Hickeyen
dc.contributor.authorDinglasan, Ericen
dc.contributor.authorHayes, Benen
dc.date.accessioned2025-01-30T18:14:13Zen
dc.date.available2025-01-30T18:14:13Zen
dc.identifier.urihttps://hdl.handle.net/10568/172571
dc.titleStacking beneficial haplotypes from the Vavilov wheat collection to accelerate breeding for multiple disease resistanceen
dcterms.abstractWheat production is threatened by numerous fungal diseases, but the potential to breed for multiple disease resistance (MDR) mechanisms is yet to be explored. Here, significant global genetic correlations and underlying local genomic regions were identified in the Vavilov wheat diversity panel for six major fungal diseases, including biotrophic leaf rust (LR), yellow rust (YR), stem rust (SR), hemibiotrophic crown rot (CR), and necrotrophic tan spot (TS) and Septoria nodorum blotch (SNB). By adopting haplotype-based local genomic estimated breeding values, derived from an integrated set of 34,899 SNP and DArT markers, we established a novel haplotype catalogue for resistance to the six diseases in over 20 field experiments across Australia and Ethiopia. Haploblocks with high variances of haplotype effects in all environments were identified for three rusts, and pleiotropic haploblocks were identified for at least two diseases, with four haploblocks affecting all six diseases. Through simulation, we demonstrated that stacking optimal haplotypes for one disease could improve resistance substantially, but indirectly affected resistance for other five diseases, which varied depending on the genetic correlation with the non-target disease trait. On the other hand, our simulation results combining beneficial haplotypes for all diseases increased resistance to LR, YR, SR, CR, TS, and SNB, by up to 48.1%, 35.2%, 29.1%, 12.8%, 18.8%, and 32.8%, respectively. Overall, our results highlight the genetic potential to improve MDR in wheat. The haploblock-based catalogue with novel forms of resistance provides a useful resource to guide desirable haplotype stacking for breeding future wheat cultivars with MDR.en
dcterms.accessRightsLimited Access
dcterms.available2024-11-21en
dcterms.bibliographicCitationTong, J., Tarekegn, Z. T., Jambuthenne, D., Alahmad, S., Periyannan, S., Hickey, L., Dinglasan, E., & Hayes, B. (2024). Stacking beneficial haplotypes from the Vavilov wheat collection to accelerate breeding for multiple disease resistance. Theoretical and Applied Genetics, 137(12), 274. https://doi.org/10.1007/s00122-024-04784-wen
dcterms.issued2024en
dcterms.languageen
dcterms.licenseCopyrighted; all rights reserved
dcterms.publisherSpringeren
dcterms.subjectwheaten
dcterms.subjectplant breedingen
dcterms.subjectdisease resistanceen
dcterms.subjecthaplotypesen
dcterms.subjectfungal diseasesen
dcterms.subjectbreeding valueen
dcterms.subjectgenetic markersen
dcterms.subjectsnp genotypingen
dcterms.typeJournal Article

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