Evidence of exposure to C. burnetii among slaughterhouse workers in western Kenya

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cg.authorship.typesCGIAR and developing country instituteen_US
cg.authorship.typesCGIAR and advanced research instituteen_US
cg.contributor.affiliationInternational Livestock Research Instituteen_US
cg.contributor.affiliationUniversity of Global Health Equityen_US
cg.contributor.affiliationUniversity of Liverpoolen_US
cg.contributor.affiliationKenya Medical Research Instituteen_US
cg.contributor.affiliationUniversity of Edinburghen_US
cg.contributor.crpAgriculture for Nutrition and Healthen_US
cg.contributor.donorWellcome Trusten_US
cg.contributor.donorMedical Research Council, United Kingdomen_US
cg.contributor.donorBiotechnology and Biological Sciences Research Council, United Kingdomen_US
cg.coverage.countryKenyaen_US
cg.coverage.iso3166-alpha2KEen_US
cg.coverage.regionAfricaen_US
cg.coverage.regionEastern Africaen_US
cg.creator.identifierElizabeth Cook: 0000-0001-6081-8363en_US
cg.creator.identifierWilliam de Glanville: 0000-0003-2474-0356en_US
cg.creator.identifierEric M. Fèvre: 0000-0001-8931-4986en_US
cg.creator.identifierVelma Kivali: 0000-0003-0797-4484en_US
cg.creator.identifierMark Bronsvoort: 0000-0002-3271-8485en_US
cg.howPublishedFormally Publisheden_US
cg.identifier.doihttps://doi.org/10.1016/j.onehlt.2021.100305en_US
cg.isijournalISI Journalen_US
cg.issn2352-7714en_US
cg.journalOne Healthen_US
cg.reviewStatusPeer Reviewen_US
cg.speciesCoxiella burnetiien_US
cg.subject.ilriHUMAN HEALTHen_US
cg.subject.ilriZOONOTIC DISEASESen_US
cg.subject.impactAreaNutrition, health and food securityen_US
cg.subject.sdgSDG 3 - Good health and well-beingen_US
cg.volume13en_US
dc.contributor.authorCook, Elizabeth A.J.en_US
dc.contributor.authorGlanville, William A. deen_US
dc.contributor.authorThomas, Lian F.en_US
dc.contributor.authorKiyong'a, Aliceen_US
dc.contributor.authorKivali, Velmaen_US
dc.contributor.authorKariuki, S.en_US
dc.contributor.authorBronsvoort, B.M. de C.en_US
dc.contributor.authorFèvre, Eric M.en_US
dc.date.accessioned2021-08-16T10:44:07Zen_US
dc.date.available2021-08-16T10:44:07Zen_US
dc.identifier.urihttps://hdl.handle.net/10568/114646en_US
dc.titleEvidence of exposure to C. burnetii among slaughterhouse workers in western Kenyaen_US
dcterms.abstractQ fever, caused by C. burnetii, has been reported in slaughterhouse workers worldwide. The most reported risk factor for seropositivity is the workers' role in the slaughterhouse. This study examined the seroprevalence and risk factors for antibodies to C. burnetii in slaughterhouse workers in western Kenya to fill a data gap relating to this emerging disease in East Africa. Individuals were recruited from all consenting slaughterhouses in the study area between February and November 2012. Information was collected from participating workers regarding demographic data, animals slaughtered and role in the slaughterhouse. Sera samples were screened for antibodies to C. burnetii using a commercial ELISA and risk factors associated with seropositivity were identified using multi-level logistic regression analysis. Slaughterhouse workers (n = 566) were recruited from 84 ruminant slaughterhouses in western Kenya. The seroprevalence of antibodies to C. burnetii was 37.1% (95% Confidence Interval (CI) 33.2–41.2%). The risk factors identified for C. burnetii seropositivity included: male workers compared to female workers, odds ratio (OR) 5.40 (95% CI 1.38–21.22); slaughtering cattle and small ruminants compared to those who only slaughtered cattle, OR 1.52 (95% CI 1.06–2.19). In addition, specific roles in the slaughterhouse were associated with increased odds of being seropositive, including cleaning the slaughterhouse, OR 3.98 (95% CI 1.39–11.43); cleaning the intestines, OR 3.24 (95% CI 1.36–7.73); and flaying the carcass OR 2.63 (95% CI 1.46–4.75) compared to being the slaughterman or foreman. We identified that slaughterhouse workers have a higher seroprevalence of antibodies to C. burnetii compared to published values in the general population from the same area. Slaughterhouse workers therefore represent an occupational risk group in this East African setting. Workers with increased contact with the viscera and fluids are at higher risk for exposure to C. burnetii. Education of workers may reduce transmission, but an alternative approach may be to consider the benefits of vaccination in high-risk groups.en_US
dcterms.accessRightsOpen Accessen_US
dcterms.audienceScientistsen_US
dcterms.audienceAcademicsen_US
dcterms.bibliographicCitationCook, E.A.J., Glanville, W.A. de, Thomas, L.F., Kiyong'a, A., Kivali, V., Kariuki, S., Bronsvoort, B.M. de C. and Fèvre, E.M. 2021. Evidence of exposure to C. burnetii among slaughterhouse workers in western Kenya. One Health 13: 100305.en_US
dcterms.extent100305en_US
dcterms.issued2021-12en_US
dcterms.languageenen_US
dcterms.licenseCC-BY-4.0en_US
dcterms.publisherElsevieren_US
dcterms.subjectzoonosesen_US
dcterms.subjectq feveren_US
dcterms.subjectoccupational healthen_US
dcterms.subjecthealthen_US
dcterms.typeJournal Articleen_US

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