Evidence of exposure to C. burnetii among slaughterhouse workers in western Kenya

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cg.authorship.typesCGIAR and developing country instituteen
cg.authorship.typesCGIAR and advanced research instituteen
cg.contributor.affiliationInternational Livestock Research Instituteen
cg.contributor.affiliationUniversity of Global Health Equityen
cg.contributor.affiliationUniversity of Liverpoolen
cg.contributor.affiliationKenya Medical Research Instituteen
cg.contributor.affiliationUniversity of Edinburghen
cg.contributor.crpAgriculture for Nutrition and Health
cg.contributor.donorWellcome Trusten
cg.contributor.donorMedical Research Council, United Kingdomen
cg.contributor.donorBiotechnology and Biological Sciences Research Council, United Kingdomen
cg.coverage.countryKenya
cg.coverage.iso3166-alpha2KE
cg.coverage.regionAfrica
cg.coverage.regionEastern Africa
cg.creator.identifierElizabeth Cook: 0000-0001-6081-8363en
cg.creator.identifierWilliam de Glanville: 0000-0003-2474-0356en
cg.creator.identifierEric M. Fèvre: 0000-0001-8931-4986en
cg.creator.identifierVelma Kivali: 0000-0003-0797-4484en
cg.creator.identifierMark Bronsvoort: 0000-0002-3271-8485en
cg.howPublishedFormally Publisheden
cg.identifier.doihttps://doi.org/10.1016/j.onehlt.2021.100305en
cg.isijournalISI Journalen
cg.issn2352-7714en
cg.journalOne Healthen
cg.reviewStatusPeer Reviewen
cg.speciesCoxiella burnetiien
cg.subject.ilriHUMAN HEALTHen
cg.subject.ilriZOONOTIC DISEASESen
cg.subject.impactAreaNutrition, health and food security
cg.subject.sdgSDG 3 - Good health and well-beingen
cg.volume13en
dc.contributor.authorCook, Elizabeth A.J.en
dc.contributor.authorGlanville, William A. deen
dc.contributor.authorThomas, Lian F.en
dc.contributor.authorKiyong'a, Aliceen
dc.contributor.authorKivali, Velmaen
dc.contributor.authorKariuki, S.en
dc.contributor.authorBronsvoort, B.M. de C.en
dc.contributor.authorFèvre, Eric M.en
dc.date.accessioned2021-08-16T10:44:07Zen
dc.date.available2021-08-16T10:44:07Zen
dc.identifier.urihttps://hdl.handle.net/10568/114646
dc.titleEvidence of exposure to C. burnetii among slaughterhouse workers in western Kenyaen
dcterms.abstractQ fever, caused by C. burnetii, has been reported in slaughterhouse workers worldwide. The most reported risk factor for seropositivity is the workers' role in the slaughterhouse. This study examined the seroprevalence and risk factors for antibodies to C. burnetii in slaughterhouse workers in western Kenya to fill a data gap relating to this emerging disease in East Africa. Individuals were recruited from all consenting slaughterhouses in the study area between February and November 2012. Information was collected from participating workers regarding demographic data, animals slaughtered and role in the slaughterhouse. Sera samples were screened for antibodies to C. burnetii using a commercial ELISA and risk factors associated with seropositivity were identified using multi-level logistic regression analysis. Slaughterhouse workers (n = 566) were recruited from 84 ruminant slaughterhouses in western Kenya. The seroprevalence of antibodies to C. burnetii was 37.1% (95% Confidence Interval (CI) 33.2–41.2%). The risk factors identified for C. burnetii seropositivity included: male workers compared to female workers, odds ratio (OR) 5.40 (95% CI 1.38–21.22); slaughtering cattle and small ruminants compared to those who only slaughtered cattle, OR 1.52 (95% CI 1.06–2.19). In addition, specific roles in the slaughterhouse were associated with increased odds of being seropositive, including cleaning the slaughterhouse, OR 3.98 (95% CI 1.39–11.43); cleaning the intestines, OR 3.24 (95% CI 1.36–7.73); and flaying the carcass OR 2.63 (95% CI 1.46–4.75) compared to being the slaughterman or foreman. We identified that slaughterhouse workers have a higher seroprevalence of antibodies to C. burnetii compared to published values in the general population from the same area. Slaughterhouse workers therefore represent an occupational risk group in this East African setting. Workers with increased contact with the viscera and fluids are at higher risk for exposure to C. burnetii. Education of workers may reduce transmission, but an alternative approach may be to consider the benefits of vaccination in high-risk groups.en
dcterms.accessRightsOpen Access
dcterms.audienceScientistsen
dcterms.audienceAcademicsen
dcterms.bibliographicCitationCook, E.A.J., Glanville, W.A. de, Thomas, L.F., Kiyong'a, A., Kivali, V., Kariuki, S., Bronsvoort, B.M. de C. and Fèvre, E.M. 2021. Evidence of exposure to C. burnetii among slaughterhouse workers in western Kenya. One Health 13: 100305.en
dcterms.extent100305en
dcterms.issued2021-12en
dcterms.languageen
dcterms.licenseCC-BY-4.0
dcterms.publisherElsevieren
dcterms.subjectzoonosesen
dcterms.subjectq feveren
dcterms.subjectoccupational healthen
dcterms.subjecthealthen
dcterms.typeJournal Article

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