Household socio-economic position and individual infectious disease risk in rural Kenya

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cg.authorship.typesCGIAR and developing country instituteen
cg.authorship.typesCGIAR and advanced research instituteen
cg.contributor.affiliationUniversity of Edinburghen
cg.contributor.affiliationInternational Livestock Research Instituteen
cg.contributor.affiliationUniversity of Glasgowen
cg.contributor.affiliationUnited States International Universityen
cg.contributor.affiliationKenya Medical Research Instituteen
cg.contributor.affiliationUniversity of Liverpoolen
cg.contributor.crpAgriculture for Nutrition and Health
cg.contributor.donorBiotechnology and Biological Sciences Research Council, United Kingdomen
cg.contributor.donorMedical Research Council, United Kingdomen
cg.contributor.donorWellcome Trusten
cg.coverage.countryKenya
cg.coverage.iso3166-alpha2KE
cg.coverage.regionAfrica
cg.coverage.regionEastern Africa
cg.creator.identifierWilliam de Glanville: 0000-0003-2474-0356en
cg.creator.identifierLian Thomas: 0000-0001-8447-1210en
cg.creator.identifierElizabeth Cook: 0000-0001-6081-8363en
cg.creator.identifierMark Bronsvoort: 0000-0002-3271-8485en
cg.creator.identifierEric M. Fèvre: 0000-0001-8931-4986en
cg.howPublishedFormally Publisheden
cg.identifier.doihttps://doi.org/10.1038/s41598-019-39375-zen
cg.isijournalISI Journalen
cg.issn2045-2322en
cg.issue1en
cg.journalScientific Reportsen
cg.reviewStatusPeer Reviewen
cg.subject.ilriAGRI-HEALTHen
cg.subject.ilriHEALTHen
cg.subject.ilriZOONOTIC DISEASESen
cg.volume9en
dc.contributor.authorGlanville, William A. deen
dc.contributor.authorThomas, Lian F.en
dc.contributor.authorCook, Elizabeth A.J.en
dc.contributor.authorBronsvoort, B.M. de C.en
dc.contributor.authorWamae, N.C.en
dc.contributor.authorKariuki, S.en
dc.contributor.authorFèvre, Eric M.en
dc.date.accessioned2019-03-05T13:56:25Zen
dc.date.available2019-03-05T13:56:25Zen
dc.identifier.urihttps://hdl.handle.net/10568/100114
dc.titleHousehold socio-economic position and individual infectious disease risk in rural Kenyaen
dcterms.abstractThe importance of household socio-economic position (SEP) in shaping individual infectious disease risk is increasingly recognised, particularly in low income settings. However, few studies have measured the extent to which this association is consistent for the range of pathogens that are typically endemic among the rural poor in the tropics. This cross-sectional study assessed the relationship between SEP and human infection within a single community in western Kenya using a set of pathogens with diverse transmission routes. The relationships between household SEP and individual infection with Plasmodium falciparum, hookworm (Ancylostoma duodenale and/or Necator americanus), Entamoeba histolytica/dispar, Mycobacterium tuberculosis, and HIV, and co-infections between hookworm, P. falciparum and E. histolytica/dispar, were assessed using multivariable logistic and multinomial regression. Individuals in households with the lowest SEP were at greatest risk of infection with P. falciparum, hookworm and E. histolytica/dispar, as well as co-infection with each pathogen. Infection with M. tuberculosis, by contrast, was most likely in individuals living in households with the highest SEP. There was no evidence of a relationship between individual HIV infection and household SEP. We demonstrate the existence of a household socio-economic gradient within a rural farming community in Kenya which impacts upon individual infectious disease risk. Structural adjustments that seek to reduce poverty, and therefore the socio-economic inequalities that exist in this community, would be expected to substantially reduce overall infectious disease burden. However, policy makers and researchers should be aware that heterogeneous relationships can exist between household SEP and infection risk for different pathogens in low income settings.en
dcterms.accessRightsOpen Access
dcterms.audienceScientistsen
dcterms.available2019-02-27en
dcterms.bibliographicCitationGlanville, W.A. de, Thomas, L.F., Cook, E.A.J., Bronsvoort, B.M. de C., Wamae, N.C., Kariuki, S. and Fèvre, E.M. 2019. Household socio-economic position and individual infectious disease risk in rural Kenya. Scientific Reports 9: 2972.en
dcterms.issued2019-02-27en
dcterms.languageen
dcterms.licenseCC-BY-4.0
dcterms.publisherSpringeren
dcterms.subjectzoonosesen
dcterms.subjecthealthen
dcterms.typeJournal Article

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