Immune parameters to p67C antigen adjuvanted with ISA206VG correlate with protection against East Coast fever

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cg.authorship.typesCGIAR single centreen
cg.contributor.affiliationInternational Livestock Research Instituteen
cg.contributor.crpLivestock
cg.contributor.donorBill & Melinda Gates Foundationen
cg.contributor.donorUnited States Agency for International Developmenten
cg.contributor.donorDepartment for International Development, United Kingdomen
cg.contributor.donorUnited States Department of Agricultureen
cg.creator.identifierAnna Lacasta: 0000-0001-8381-9844
cg.creator.identifierElizabeth Jane Poole: 0000-0002-8570-794X
cg.creator.identifierLucilla Steinaa: 0000-0003-3691-3971
cg.creator.identifierVishvanath Nene: 0000-0001-7066-4169
cg.creator.identifierRoger Pelle: 0000-0003-1053-085X
cg.howPublishedFormally Publisheden
cg.identifier.doihttps://doi.org/10.1016/j.vaccine.2018.01.087en
cg.isijournalISI Journalen
cg.issn0264-410Xen
cg.issue11en
cg.journalVaccineen
cg.reviewStatusPeer Reviewen
cg.speciesTheileria parvaen
cg.subject.ilriANIMAL DISEASESen
cg.subject.ilriCATTLEen
cg.subject.ilriDISEASE CONTROLen
cg.subject.ilriECFen
cg.subject.ilriLIVESTOCKen
cg.subject.ilriVACCINESen
cg.volume36en
dc.contributor.authorLacasta, Annaen
dc.contributor.authorMwalimu, Stephenen
dc.contributor.authorKibwana, Elisabethen
dc.contributor.authorSaya, R.en
dc.contributor.authorAwino, Eliasen
dc.contributor.authorNjoroge, Thomasen
dc.contributor.authorPoole, Elizabeth J.en
dc.contributor.authorNdiwa, Nicholas N.en
dc.contributor.authorPelle, Rogeren
dc.contributor.authorNene, Vishvanath M.en
dc.contributor.authorSteinaa, Lucillaen
dc.date.accessioned2018-02-19T13:38:28Zen
dc.date.available2018-02-19T13:38:28Zen
dc.identifier.urihttps://hdl.handle.net/10568/91022
dc.titleImmune parameters to p67C antigen adjuvanted with ISA206VG correlate with protection against East Coast feveren
dcterms.abstractEast Coast fever (ECF) is a lymphoproliferative disease caused by the tick-transmitted protozoan parasite Theileria parva. ECF is one of the most serious cattle tick-borne diseases in Sub-Saharan Africa. We have previously demonstrated that three doses of the C-terminal part of the sporozoite protein p67 (p67C) adjuvanted with ISA206VG confers partial protection against ECF at a herd level. We have tested the efficacy of two doses of this experimental vaccine, as reducing the vaccination regimen would facilitate its deployment in the field. We reconfirm that three antigen doses gave a significant level of protection to severe disease (46%, ECF score < 6) when compared with the control group, while two doses did not (23%). Animals receiving three doses of p67C developed higher antibody titers and CD4+ T-cell proliferation indices, than those which received two doses. A new panel of immune parameters were tested in order to identify factors correlating with protection: CD4+ proliferation index, total IgG, IgG1, IgG2 and IgM half maximal titers and neutralization capacity of the sera with and without complement. We show that some of the cellular and humoral immune responses provide preliminary correlates of protection.en
dcterms.accessRightsOpen Access
dcterms.audienceScientistsen
dcterms.bibliographicCitationLacasta, A., Mwalimu, S., Kibwana, E., Saya, R., Awino, E., Njoroge, T., Poole, J., Ndiwa, N., Pelle, R., Nene, V. and Steinaa, L. 2018. Immune parameters to p67C antigen adjuvanted with ISA206VG correlate with protection against East Coast fever. Vaccine 36(11):1389–1397.en
dcterms.extentp. 1389-1397en
dcterms.issued2018-03
dcterms.languageen
dcterms.licenseCC-BY-4.0
dcterms.publisherElsevieren
dcterms.subjecttheileriaen
dcterms.subjectcattleen
dcterms.subjectanimal diseasesen
dcterms.subjectvaccinesen
dcterms.subjectdisease controlen
dcterms.subjecteast coast feveren
dcterms.typeJournal Article

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