Immune parameters to p67C antigen adjuvanted with ISA206VG correlate with protection against East Coast fever

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cg.authorship.typesCGIAR single centreen_US
cg.contributor.affiliationInternational Livestock Research Instituteen_US
cg.contributor.crpLivestocken_US
cg.contributor.donorBill & Melinda Gates Foundationen_US
cg.contributor.donorUnited States Agency for International Developmenten_US
cg.contributor.donorDepartment for International Development, United Kingdomen_US
cg.contributor.donorUnited States Department of Agricultureen_US
cg.creator.identifierAnna Lacasta: 0000-0001-8381-9844en_US
cg.creator.identifierElizabeth Jane Poole: 0000-0002-8570-794Xen_US
cg.creator.identifierLucilla Steinaa: 0000-0003-3691-3971en_US
cg.creator.identifierVishvanath Nene: 0000-0001-7066-4169en_US
cg.creator.identifierRoger Pelle: 0000-0003-1053-085Xen_US
cg.howPublishedFormally Publisheden_US
cg.identifier.doihttps://doi.org/10.1016/j.vaccine.2018.01.087en_US
cg.isijournalISI Journalen_US
cg.issn0264-410Xen_US
cg.issue11en_US
cg.journalVaccineen_US
cg.reviewStatusPeer Reviewen_US
cg.speciesTheileria parvaen_US
cg.subject.ilriANIMAL DISEASESen_US
cg.subject.ilriCATTLEen_US
cg.subject.ilriDISEASE CONTROLen_US
cg.subject.ilriECFen_US
cg.subject.ilriLIVESTOCKen_US
cg.subject.ilriVACCINESen_US
cg.volume36en_US
dc.contributor.authorLacasta, Annaen_US
dc.contributor.authorMwalimu, Stephenen_US
dc.contributor.authorKibwana, Elisabethen_US
dc.contributor.authorSaya, R.en_US
dc.contributor.authorAwino, Eliasen_US
dc.contributor.authorNjoroge, Thomasen_US
dc.contributor.authorPoole, Elizabeth J.en_US
dc.contributor.authorNdiwa, Nicholas N.en_US
dc.contributor.authorPelle, Rogeren_US
dc.contributor.authorNene, Vishvanath M.en_US
dc.contributor.authorSteinaa, Lucillaen_US
dc.date.accessioned2018-02-19T13:38:28Zen_US
dc.date.available2018-02-19T13:38:28Zen_US
dc.identifier.urihttps://hdl.handle.net/10568/91022en_US
dc.titleImmune parameters to p67C antigen adjuvanted with ISA206VG correlate with protection against East Coast feveren_US
dcterms.abstractEast Coast fever (ECF) is a lymphoproliferative disease caused by the tick-transmitted protozoan parasite Theileria parva. ECF is one of the most serious cattle tick-borne diseases in Sub-Saharan Africa. We have previously demonstrated that three doses of the C-terminal part of the sporozoite protein p67 (p67C) adjuvanted with ISA206VG confers partial protection against ECF at a herd level. We have tested the efficacy of two doses of this experimental vaccine, as reducing the vaccination regimen would facilitate its deployment in the field. We reconfirm that three antigen doses gave a significant level of protection to severe disease (46%, ECF score < 6) when compared with the control group, while two doses did not (23%). Animals receiving three doses of p67C developed higher antibody titers and CD4+ T-cell proliferation indices, than those which received two doses. A new panel of immune parameters were tested in order to identify factors correlating with protection: CD4+ proliferation index, total IgG, IgG1, IgG2 and IgM half maximal titers and neutralization capacity of the sera with and without complement. We show that some of the cellular and humoral immune responses provide preliminary correlates of protection.en_US
dcterms.accessRightsOpen Accessen_US
dcterms.audienceScientistsen_US
dcterms.bibliographicCitationLacasta, A., Mwalimu, S., Kibwana, E., Saya, R., Awino, E., Njoroge, T., Poole, J., Ndiwa, N., Pelle, R., Nene, V. and Steinaa, L. 2018. Immune parameters to p67C antigen adjuvanted with ISA206VG correlate with protection against East Coast fever. Vaccine 36(11):1389–1397.en_US
dcterms.extentp. 1389-1397en_US
dcterms.issued2018-03en_US
dcterms.languageenen_US
dcterms.licenseCC-BY-4.0en_US
dcterms.publisherElsevieren_US
dcterms.subjecttheileriaen_US
dcterms.subjectcattleen_US
dcterms.subjectanimal diseasesen_US
dcterms.subjectvaccinesen_US
dcterms.subjectdisease controlen_US
dcterms.subjecteast coast feveren_US
dcterms.typeJournal Articleen_US

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