A novel Nobecovirus in an Epomophorus wahlbergi bat from Nairobi, Kenya

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cg.authorship.typesCGIAR and developing country instituteen
cg.authorship.typesCGIAR and advanced research instituteen
cg.contributor.affiliationUniversity of Californiaen
cg.contributor.affiliationSmithsonian Institutionen
cg.contributor.affiliationWalter Reed Army Institute of Researchen
cg.contributor.affiliationHacettepe Universityen
cg.contributor.affiliationMaasai Mara Universityen
cg.contributor.affiliationMpala Research Centreen
cg.contributor.affiliationUniversity of Arkansasen
cg.contributor.affiliationUniversity of Notre Dameen
cg.contributor.affiliationNaval Medical Research Commanden
cg.contributor.affiliationUniversity of Eldoreten
cg.contributor.affiliationUniversity of Nairobien
cg.contributor.affiliationUniversity of Minnesotaen
cg.contributor.affiliationUniversity of Liverpoolen
cg.contributor.affiliationInternational Livestock Research Instituteen
cg.contributor.affiliationYale School of Public Healthen
cg.contributor.donorSmithsonian Institutionen
cg.contributor.donorUnited States Army Medical Research and Development Commanden
cg.contributor.donorMedical Research Council, United Kingdomen
cg.contributor.donorBiotechnology and Biological Sciences Research Council, United Kingdomen
cg.contributor.donorEconomic and Social Research Council, United Kingdomen
cg.contributor.donorNatural Environment Research Council, United Kingdomen
cg.contributor.donorCGIAR Trust Funden
cg.contributor.initiativeOne Healthen
cg.coverage.countryKenyaen
cg.coverage.iso3166-alpha2KEen
cg.coverage.regionAfricaen
cg.coverage.regionEastern Africaen
cg.creator.identifierEric M. Fèvre: 0000-0001-8931-4986en
cg.creator.identifierJames Hassell: 0000-0002-4710-2827en
cg.howPublishedFormally Publisheden
cg.identifier.doihttps://doi.org/10.3390/v17040557en
cg.isijournalISI Journalen
cg.issn1999-4915en
cg.issue4en
cg.journalVirusesen
cg.reviewStatusPeer Reviewen
cg.speciesEpomophorus wahlbergien
cg.subject.actionAreaResilient Agrifood Systemsen
cg.subject.ilriWILDLIFEen
cg.subject.impactAreaNutrition, health and food securityen
cg.subject.sdgSDG 3 - Good health and well-beingen
cg.volume17en
dc.contributor.authorVanAcker, M.C.en
dc.contributor.authorErgunay, K.en
dc.contributor.authorWebala, P.W.en
dc.contributor.authorKamau, M.en
dc.contributor.authorMutura, J.en
dc.contributor.authorLebunge, R.en
dc.contributor.authorOchola, G.O.en
dc.contributor.authorBourke, B.P.en
dc.contributor.authorMcDermott, E.G.en
dc.contributor.authorAchee, N.L.en
dc.contributor.authorJiang, L.en
dc.contributor.authorGrieco, J.P.en
dc.contributor.authorKeter, E.en
dc.contributor.authorMusanga, A.en
dc.contributor.authorMurray, S.en
dc.contributor.authorStabach, J.A.en
dc.contributor.authorCraft, M.E.en
dc.contributor.authorFèvre, Eric M.en
dc.contributor.authorLinton, Y.-M.en
dc.contributor.authorHassell, Jamesen
dc.date.accessioned2025-04-15T06:58:35Zen
dc.date.available2025-04-15T06:58:35Zen
dc.identifier.urihttps://hdl.handle.net/10568/174184
dc.titleA novel Nobecovirus in an Epomophorus wahlbergi bat from Nairobi, Kenyaen
dcterms.abstractMost human emerging infectious diseases are zoonotic, originating in animal hosts prior to spillover to humans. Prioritizing the surveillance of wildlife that overlaps with humans and human activities can increase the likelihood of detecting viruses with a high potential for human infection. Here, we obtained fecal swabs from two fruit bat species—<i>Eidolon helvum</i> (n = 6) and <i>Epomophorus wahlbergi</i> (n = 43) (family Pteropodidae)—in peridomestic habitats in Nairobi, Kenya, and used metagenome sequencing to detect microorganisms. A near-complete genome of a novel virus assigned taxonomically to the <i>Coronaviridae</i> family <i>Betacoronavirus</i> genus and <i>Nobecovirus</i> subclade was characterized from <i>E. wahlbergi</i>. Phylogenetic analysis indicates this unique Nobecovirus clade shares a common ancestor with Eidolon/Rousettus Nobecovirus subclades isolated from Madagascar, Kenya, and Cameroon. Recombination was detected across open reading frames, except the spike protein, in all BOOTSCAN analyses, indicating intra-host coinfection and genetic exchange between genome regions. Although Nobecoviruses are currently bat-specific and are not known to be zoonotic, the propensity of coronaviruses to undergo frequent recombination events and the location of the virus alongside high human and livestock densities in one of East Africa’s most rapidly developing cities justifies continued surveillance of animal viruses in high-risk urban landscapes.en
dcterms.accessRightsOpen Accessen
dcterms.audienceAcademicsen
dcterms.audienceScientistsen
dcterms.available2025-04-12en
dcterms.bibliographicCitationVanAcker, M.C., Ergunay, K., Webala, P.W., Kamau, M., Mutura, J., Lebunge, R., Ochola, G.O., Bourke, B.P., McDermott, E.G., Achee, N.L., Jiang, L., Grieco, J.P., Keter, E., Musanga, A., Murray, S., Stabach, J.A., Craft, M.E., Fèvre, E.M., Linton, Y.-M. and Hassell, J. 2025. A novel <i>Nobecovirus</i> in an <i>Epomophorus wahlbergi</i> bat from Nairobi, Kenya. Viruses 17(4): 557.en
dcterms.extent557en
dcterms.issued2025-04-12en
dcterms.languageenen
dcterms.licenseCC-BY-4.0en
dcterms.publisherMDPIen
dcterms.subjectgenomicsen
dcterms.subjectwildlifeen
dcterms.typeJournal Articleen

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