Using the microbiota to study connectivity at human–animal interfaces

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cg.authorship.typesCGIAR and developing country institute
cg.authorship.typesCGIAR and advanced research institute
cg.contributor.affiliationInternational Livestock Research Institute
cg.contributor.affiliationUniversity of Liverpool
cg.contributor.affiliationCentre de Coopération Internationale en Recherche Agronomique pour le Développement
cg.contributor.affiliationKEMRI-Wellcome Trust Research Programme
cg.contributor.affiliationChildhood Acute Illness and Nutrition Network, Kenya
cg.contributor.affiliationUniversity of Oxford
cg.contributor.affiliationSmithsonian's National Zoo and Conservation Biology Institute
cg.contributor.affiliationYale School of Public Health
cg.contributor.affiliationCornell University
cg.contributor.affiliationUniversity of British Columbia
cg.contributor.affiliationUniversity of Copenhagen
cg.contributor.donorCGIAR Trust Fund
cg.contributor.initiativeOne Health
cg.creator.identifierDishon Muloi: 0000-0002-6236-2280
cg.creator.identifierAlexandre Caron: 0000-0002-5213-3273
cg.creator.identifierJames Hassell: 0000-0002-4710-2827
cg.creator.identifierArshnee Moodley: 0000-0002-6469-3948
cg.creator.identifierEric M. Fèvre: 0000-0001-8931-4986
cg.howPublishedFormally Published
cg.identifier.doihttps://doi.org/10.1016/j.tim.2025.05.006
cg.isijournalISI Journal
cg.issn0966-842X
cg.journalTrends in Microbiology
cg.reviewStatusPeer Review
cg.subject.actionAreaResilient Agrifood Systems
cg.subject.ilriHUMAN HEALTH
cg.subject.impactAreaNutrition, health and food security
cg.subject.sdgSDG 3 - Good health and well-being
dc.contributor.authorMuloi, Dishon M.
dc.contributor.authorCaron, Alexandre
dc.contributor.authorBerkley, J.A.
dc.contributor.authorHassell, James M.
dc.contributor.authorBrito, I.L.
dc.contributor.authorKing, K.
dc.contributor.authorMoodley, Arshnee
dc.contributor.authorFèvre, Eric M.
dc.date.accessioned2025-06-12T04:22:28Z
dc.date.available2025-06-12T04:22:28Z
dc.identifier.urihttps://hdl.handle.net/10568/175067
dc.titleUsing the microbiota to study connectivity at human–animal interfacesen
dcterms.abstractInterfaces between humans, livestock, and wildlife, mediated by the environment, are critical points for the transmission and emergence of infectious pathogens and call for leveraging the One Health approach to understanding disease transmission. Current research on pathogen transmission often focuses on single-pathogen systems, providing a limited understanding of the broader microbial interactions occurring at these interfaces. In this review, we make a case for the study of host-associated microbiota for understanding connectivity between host populations at human–animal interfaces. First, we emphasize the need to understand changes in microbiota composition dynamics from interspecies contact. Then, we explore the potential for microbiota monitoring at such interfaces as a predictive tool for infectious disease transmission and as an early-warning system to inform public health interventions. We discuss the methodological challenges and gaps in knowledge in analyzing microbiota composition dynamics, the functional meaning of these changes, and how to establish causality between microbiota changes and health outcomes. We posit that integrating microbiota science with social-ecological systems modeling is essential for advancing our ability to manage health risks and harness opportunities arising from interspecies interactions.en
dcterms.accessRightsOpen Access
dcterms.audienceAcademics
dcterms.audienceScientists
dcterms.audienceCGIAR
dcterms.audienceDonors
dcterms.available2025-06-09
dcterms.bibliographicCitationMuloi, D.M., Caron, A., Berkley, J.A., Hassell, J.M., Brito, I.L., King, K., Moodley, A. and Fèvre, E.M. 2025. Using the microbiota to study connectivity at human–animal interfaces. Trends in Microbiology.
dcterms.issued2025
dcterms.languageen
dcterms.licenseCC-BY-4.0
dcterms.publisherCell Press
dcterms.subjecthealth
dcterms.subjectmicrobial flora
dcterms.typeJournal Article

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