Link of a ubiquitous human coronavirus to dromedary camels

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cg.authorship.typesCGIAR and developing country instituteen_US
cg.authorship.typesCGIAR and advanced research instituteen_US
cg.contributor.affiliationUniversity of Bonnen_US
cg.contributor.affiliationGerman Centre for Infection Researchen_US
cg.contributor.affiliationAlfaisal Universityen_US
cg.contributor.affiliationInternational Livestock Research Instituteen_US
cg.contributor.affiliationUniversity of Bernen_US
cg.contributor.affiliationInstitute of Virology and Immunology, Switzerlanden_US
cg.contributor.affiliationDepartment of Veterinary Services, Kenyaen_US
cg.contributor.affiliationVétérinaires Sans Frontièresen_US
cg.contributor.affiliationMinistry of Health, Saudi Arabiaen_US
cg.contributor.affiliationMinistry of Science and Communication, Sudanen_US
cg.contributor.affiliationCairo Universityen_US
cg.contributor.affiliationNational Veterinary Institute, Swedenen_US
cg.contributor.affiliationCentral Veterinary Research Laboratory, Dubaien_US
cg.contributor.crpAgriculture for Nutrition and Healthen_US
cg.contributor.donorDeutsche Forschungsgemeinschaften_US
cg.creator.identifierAnne Liljander: 0000-0002-7543-5493en_US
cg.creator.identifierJoerg Jores: 0000-0003-3790-5746en_US
cg.howPublishedFormally Publisheden_US
cg.identifier.doihttps://doi.org/10.1073/pnas.1604472113en_US
cg.isijournalISI Journalen_US
cg.issn1091-6490en_US
cg.issue35en_US
cg.journalProceedings of the National Academy of Sciences of the United States of Americaen_US
cg.reviewStatusPeer Reviewen_US
cg.subject.ilriANIMAL DISEASESen_US
cg.subject.ilriCAMELSen_US
cg.subject.ilriLIVESTOCKen_US
cg.subject.ilriZOONOTIC DISEASESen_US
cg.volume113en_US
dc.contributor.authorCorman, V.M.en_US
dc.contributor.authorEckerle, I.en_US
dc.contributor.authorMemish, Z.A.en_US
dc.contributor.authorLiljander, Anne M.en_US
dc.contributor.authorDijkman, R.en_US
dc.contributor.authorJonsdottir, H.en_US
dc.contributor.authorNgeiywa, K.J.Z.J.en_US
dc.contributor.authorKamau, E.en_US
dc.contributor.authorYounan, M.en_US
dc.contributor.authorAl Masri, M.en_US
dc.contributor.authorAssiri, A.en_US
dc.contributor.authorGluecks, Ilona V.en_US
dc.contributor.authorMusa, B.E.en_US
dc.contributor.authorMeyer, B.en_US
dc.contributor.authorMüller, M.A.en_US
dc.contributor.authorHilali, Mosaaden_US
dc.contributor.authorBornstein, S.en_US
dc.contributor.authorWernery, U.en_US
dc.contributor.authorThiel, V.en_US
dc.contributor.authorJores, Joergen_US
dc.contributor.authorDrexler, J.F.en_US
dc.contributor.authorDrosten, C.en_US
dc.date.accessioned2016-10-13T07:08:41Zen_US
dc.date.available2016-10-13T07:08:41Zen_US
dc.identifier.urihttps://hdl.handle.net/10568/77264en_US
dc.titleLink of a ubiquitous human coronavirus to dromedary camelsen_US
dcterms.abstractThe four human coronaviruses (HCoVs) are globally endemic respiratory pathogens. The Middle East respiratory syndrome (MERS) coronavirus (CoV) is an emerging CoV with a known zoonotic source in dromedary camels. Little is known about the origins of endemic HCoVs. Studying these viruses’ evolutionary history could provide important insight into CoV emergence. In tests of MERS-CoV–infected dromedaries, we found viruses related to an HCoV, known as HCoV-229E, in 5.6% of 1,033 animals. Human- and dromedary-derived viruses are each monophyletic, suggesting ecological isolation. One gene of dromedary viruses exists in two versions in camels, full length and deleted, whereas only the deleted version exists in humans. The deletion increased in size over a succession starting from camelid viruses via old human viruses to contemporary human viruses. Live isolates of dromedary 229E viruses were obtained and studied to assess human infection risks. The viruses used the human entry receptor aminopeptidase N and replicated in human hepatoma cells, suggesting a principal ability to cause human infections. However, inefficient replication in several mucosa-derived cell lines and airway epithelial cultures suggested lack of adaptation to the human host. Dromedary viruses were as sensitive to the human type I interferon response as HCoV-229E. Antibodies in human sera neutralized dromedary-derived viruses, suggesting population immunity against dromedary viruses. Although no current epidemic risk seems to emanate from these viruses, evolutionary inference suggests that the endemic human virus HCoV-229E may constitute a descendant of camelid-associated viruses. HCoV-229E evolution provides a scenario for MERS-CoV emergence.en_US
dcterms.accessRightsOpen Accessen_US
dcterms.audienceScientistsen_US
dcterms.available2016-08-15en_US
dcterms.bibliographicCitationCorman, V.M., Eckerle, I., Memish, Z.A., Liljander, A.M., Dijkman, R., Jonsdottir, H., Ngeiywa, K.J.Z.J., Kamau, E., Younan, M., Al Masri, M., Assiri, A., Gluecks, I., Musa, B.E., Meyer, B., Müller, M.A., Hilali, M., Bornstein, S., Wernery, U., Thiel, V., Jores, J., Drexler, J.F. and Drosten, C. 2016. Link of a ubiquitous human coronavirus to dromedary camels. Proceedings of the National Academy of Sciences of the United States of America 113(35): 9864–9869.en_US
dcterms.extentp. 9864-9869en_US
dcterms.issued2016-08-30en_US
dcterms.languageenen_US
dcterms.licenseCopyrighted; all rights reserveden_US
dcterms.publisherNational Academy of Sciencesen_US
dcterms.subjectcamelsen_US
dcterms.subjectanimal diseasesen_US
dcterms.subjectzoonosesen_US
dcterms.typeJournal Articleen_US

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