Link of a ubiquitous human coronavirus to dromedary camels

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cg.authorship.typesCGIAR and developing country instituteen
cg.authorship.typesCGIAR and advanced research instituteen
cg.contributor.affiliationUniversity of Bonnen
cg.contributor.affiliationGerman Centre for Infection Researchen
cg.contributor.affiliationAlfaisal Universityen
cg.contributor.affiliationInternational Livestock Research Instituteen
cg.contributor.affiliationUniversity of Bernen
cg.contributor.affiliationInstitute of Virology and Immunology, Switzerlanden
cg.contributor.affiliationDepartment of Veterinary Services, Kenyaen
cg.contributor.affiliationVétérinaires Sans Frontièresen
cg.contributor.affiliationMinistry of Health, Saudi Arabiaen
cg.contributor.affiliationMinistry of Science and Communication, Sudanen
cg.contributor.affiliationCairo Universityen
cg.contributor.affiliationNational Veterinary Institute, Swedenen
cg.contributor.affiliationCentral Veterinary Research Laboratory, Dubaien
cg.contributor.crpAgriculture for Nutrition and Health
cg.contributor.donorDeutsche Forschungsgemeinschaften
cg.creator.identifierAnne Liljander: 0000-0002-7543-5493
cg.creator.identifierJoerg Jores: 0000-0003-3790-5746
cg.howPublishedFormally Publisheden
cg.identifier.doihttps://doi.org/10.1073/pnas.1604472113en
cg.isijournalISI Journalen
cg.issn1091-6490en
cg.issue35en
cg.journalProceedings of the National Academy of Sciences of the United States of Americaen
cg.reviewStatusPeer Reviewen
cg.subject.ilriANIMAL DISEASESen
cg.subject.ilriCAMELSen
cg.subject.ilriLIVESTOCKen
cg.subject.ilriZOONOTIC DISEASESen
cg.volume113en
dc.contributor.authorCorman, V.M.en
dc.contributor.authorEckerle, I.en
dc.contributor.authorMemish, Z.A.en
dc.contributor.authorLiljander, Anne M.en
dc.contributor.authorDijkman, R.en
dc.contributor.authorJonsdottir, H.en
dc.contributor.authorNgeiywa, K.J.Z.J.en
dc.contributor.authorKamau, E.en
dc.contributor.authorYounan, M.en
dc.contributor.authorAl Masri, M.en
dc.contributor.authorAssiri, A.en
dc.contributor.authorGluecks, Ilona V.en
dc.contributor.authorMusa, B.E.en
dc.contributor.authorMeyer, B.en
dc.contributor.authorMüller, M.A.en
dc.contributor.authorHilali, Mosaaden
dc.contributor.authorBornstein, S.en
dc.contributor.authorWernery, U.en
dc.contributor.authorThiel, V.en
dc.contributor.authorJores, Joergen
dc.contributor.authorDrexler, J.F.en
dc.contributor.authorDrosten, C.en
dc.date.accessioned2016-10-13T07:08:41Zen
dc.date.available2016-10-13T07:08:41Zen
dc.identifier.urihttps://hdl.handle.net/10568/77264
dc.titleLink of a ubiquitous human coronavirus to dromedary camelsen
dcterms.abstractThe four human coronaviruses (HCoVs) are globally endemic respiratory pathogens. The Middle East respiratory syndrome (MERS) coronavirus (CoV) is an emerging CoV with a known zoonotic source in dromedary camels. Little is known about the origins of endemic HCoVs. Studying these viruses’ evolutionary history could provide important insight into CoV emergence. In tests of MERS-CoV–infected dromedaries, we found viruses related to an HCoV, known as HCoV-229E, in 5.6% of 1,033 animals. Human- and dromedary-derived viruses are each monophyletic, suggesting ecological isolation. One gene of dromedary viruses exists in two versions in camels, full length and deleted, whereas only the deleted version exists in humans. The deletion increased in size over a succession starting from camelid viruses via old human viruses to contemporary human viruses. Live isolates of dromedary 229E viruses were obtained and studied to assess human infection risks. The viruses used the human entry receptor aminopeptidase N and replicated in human hepatoma cells, suggesting a principal ability to cause human infections. However, inefficient replication in several mucosa-derived cell lines and airway epithelial cultures suggested lack of adaptation to the human host. Dromedary viruses were as sensitive to the human type I interferon response as HCoV-229E. Antibodies in human sera neutralized dromedary-derived viruses, suggesting population immunity against dromedary viruses. Although no current epidemic risk seems to emanate from these viruses, evolutionary inference suggests that the endemic human virus HCoV-229E may constitute a descendant of camelid-associated viruses. HCoV-229E evolution provides a scenario for MERS-CoV emergence.en
dcterms.accessRightsOpen Access
dcterms.audienceScientistsen
dcterms.available2016-08-15
dcterms.bibliographicCitationCorman, V.M., Eckerle, I., Memish, Z.A., Liljander, A.M., Dijkman, R., Jonsdottir, H., Ngeiywa, K.J.Z.J., Kamau, E., Younan, M., Al Masri, M., Assiri, A., Gluecks, I., Musa, B.E., Meyer, B., Müller, M.A., Hilali, M., Bornstein, S., Wernery, U., Thiel, V., Jores, J., Drexler, J.F. and Drosten, C. 2016. Link of a ubiquitous human coronavirus to dromedary camels. Proceedings of the National Academy of Sciences of the United States of America 113(35): 9864–9869.en
dcterms.extentp. 9864-9869en
dcterms.issued2016-08-30
dcterms.languageen
dcterms.licenseCopyrighted; all rights reserved
dcterms.publisherNational Academy of Sciencesen
dcterms.subjectcamelsen
dcterms.subjectanimal diseasesen
dcterms.subjectzoonosesen
dcterms.typeJournal Article

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